Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique

Objectives: During the period from December 2007 to November 2012, the epidemiology of diarrhea caused by Shigella was studied among children <5 years of age residing in Manhiça District, Southern Mozambique. Materials and methods: Children from 0 to 5 years with moderate-to-severe diarrhea (MSD)...

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Autores: Vubil, Delfino, Acácio, Sozinho, Quintó, Llorenç, Ballesté Delpierre, Clara Celia, Nhampossa, Tacilta, Kotloff, Karen L., Levine, Myron M., Alonso, Pedro, Nataro, James P., Farag, Tamer H., Vila Estapé, Jordi, Mandomando, Inácio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/134918
Acceso en línea:https://hdl.handle.net/2445/134918
Access Level:acceso abierto
Palabra clave:Diarrea
Epidemiologia
Moçambic
Diarrhea
Epidemiology
Mozambique
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spelling Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural MozambiqueVubil, DelfinoAcácio, SozinhoQuintó, LlorençBallesté Delpierre, Clara CeliaNhampossa, TaciltaKotloff, Karen L.Levine, Myron M.Alonso, PedroNataro, James P.Farag, Tamer H.Vila Estapé, JordiMandomando, InácioDiarreaEpidemiologiaMoçambicDiarrheaEpidemiologyMozambiqueObjectives: During the period from December 2007 to November 2012, the epidemiology of diarrhea caused by Shigella was studied among children <5 years of age residing in Manhiça District, Southern Mozambique. Materials and methods: Children from 0 to 5 years with moderate-to-severe diarrhea (MSD) and less severe diarrhea (LSD) were enrolled along with matched controls (by age, gender, and neighborhood). Age-stratified logistic regression analyses were conducted to identify clinical features and risk factors associated with Shigella positivity in cases of diarrhea. The impact of antibiotic treatment was assessed for patients with known outcome. Results: A total of 916 cases of MSD and 1979 matched controls, and 431 cases of LSD with equal number of controls were enrolled. Shigella was identified as significant pathogen in both cases of MSD and LSD compared to their respective controls. Shigella was detected in 3.9% (17/431) of LSD compared to 0.5% (2/431) in controls (P=0.001) and in 6.1% (56/916) of MSD cases compared to 0.2% (4/1979) in controls (P<0.0001), with an attributable fraction of 8.55% (95% CI: 7.86–9.24) among children aged 12–23 months. Clinical symptoms associated to Shigella among MSD cases included dysentery, fever, and rectal prolapse. Water availability, giving stored water to child, washing hands before preparing baby’s food, and mother as caretaker were the protective factors against acquiring diarrhea caused by Shigella. Antibiotic treatment on admission was associated with a positive children outcome. Conclusion: Shigella remains a common pathogen associated with childhood diarrhea in Mozambique, with dysentery being a significant clinical feature of shigellosis. Adherence to the basic hygiene rules and the use of antibiotic treatment could contribute to the prevention of most of diarrhea due to Shigella.Dove Medical Press2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/134918Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.2147/IDR.S177579Infection and Drug Resistance, 2018, vol. 2018, num. 11, p. 2095-2106http://dx.doi.org/10.2147/IDR.S177579cc by-nc (c) Dove Medical Press, 2018http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1349182026-05-29T05:05:01Z
dc.title.none.fl_str_mv Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
title Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
spellingShingle Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
Vubil, Delfino
Diarrea
Epidemiologia
Moçambic
Diarrhea
Epidemiology
Mozambique
title_short Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
title_full Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
title_fullStr Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
title_full_unstemmed Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
title_sort Clinical features, risk factors, and impact of antibiotic treatment of diarrhea caused by Shigella in children less than 5 years in Manhiça District, rural Mozambique
dc.creator.none.fl_str_mv Vubil, Delfino
Acácio, Sozinho
Quintó, Llorenç
Ballesté Delpierre, Clara Celia
Nhampossa, Tacilta
Kotloff, Karen L.
Levine, Myron M.
Alonso, Pedro
Nataro, James P.
Farag, Tamer H.
Vila Estapé, Jordi
Mandomando, Inácio
author Vubil, Delfino
author_facet Vubil, Delfino
Acácio, Sozinho
Quintó, Llorenç
Ballesté Delpierre, Clara Celia
Nhampossa, Tacilta
Kotloff, Karen L.
Levine, Myron M.
Alonso, Pedro
Nataro, James P.
Farag, Tamer H.
Vila Estapé, Jordi
Mandomando, Inácio
author_role author
author2 Acácio, Sozinho
Quintó, Llorenç
Ballesté Delpierre, Clara Celia
Nhampossa, Tacilta
Kotloff, Karen L.
Levine, Myron M.
Alonso, Pedro
Nataro, James P.
Farag, Tamer H.
Vila Estapé, Jordi
Mandomando, Inácio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diarrea
Epidemiologia
Moçambic
Diarrhea
Epidemiology
Mozambique
topic Diarrea
Epidemiologia
Moçambic
Diarrhea
Epidemiology
Mozambique
description Objectives: During the period from December 2007 to November 2012, the epidemiology of diarrhea caused by Shigella was studied among children <5 years of age residing in Manhiça District, Southern Mozambique. Materials and methods: Children from 0 to 5 years with moderate-to-severe diarrhea (MSD) and less severe diarrhea (LSD) were enrolled along with matched controls (by age, gender, and neighborhood). Age-stratified logistic regression analyses were conducted to identify clinical features and risk factors associated with Shigella positivity in cases of diarrhea. The impact of antibiotic treatment was assessed for patients with known outcome. Results: A total of 916 cases of MSD and 1979 matched controls, and 431 cases of LSD with equal number of controls were enrolled. Shigella was identified as significant pathogen in both cases of MSD and LSD compared to their respective controls. Shigella was detected in 3.9% (17/431) of LSD compared to 0.5% (2/431) in controls (P=0.001) and in 6.1% (56/916) of MSD cases compared to 0.2% (4/1979) in controls (P<0.0001), with an attributable fraction of 8.55% (95% CI: 7.86–9.24) among children aged 12–23 months. Clinical symptoms associated to Shigella among MSD cases included dysentery, fever, and rectal prolapse. Water availability, giving stored water to child, washing hands before preparing baby’s food, and mother as caretaker were the protective factors against acquiring diarrhea caused by Shigella. Antibiotic treatment on admission was associated with a positive children outcome. Conclusion: Shigella remains a common pathogen associated with childhood diarrhea in Mozambique, with dysentery being a significant clinical feature of shigellosis. Adherence to the basic hygiene rules and the use of antibiotic treatment could contribute to the prevention of most of diarrhea due to Shigella.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134918
url https://hdl.handle.net/2445/134918
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.2147/IDR.S177579
Infection and Drug Resistance, 2018, vol. 2018, num. 11, p. 2095-2106
http://dx.doi.org/10.2147/IDR.S177579
dc.rights.none.fl_str_mv cc by-nc (c) Dove Medical Press, 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Dove Medical Press, 2018
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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