Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet

Obesity and diabetes incidence rates are increasing dramatically, reaching pandemic proportions. Therefore, there is an urgent need to unravel the mechanisms underlying their pathophysiology. Of particular interest is the close interconnection between gut microbiota dysbiosis and obesity and diabete...

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Autores: Díez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8, Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb, Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6, Lorente-Cebrian, S. (Silvia)|||/items/35e493b5-619e-4ff6-9e7a-22ed03cd9205
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/63874
Acceso en línea:https://hdl.handle.net/10171/63874
Access Level:acceso abierto
Palabra clave:Exosomes
Probiotics
MicroRNA
Dysbiosis
Inflammation
Akkermansia muciniphila
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spelling Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through dietDíez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebRiezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6Lorente-Cebrian, S. (Silvia)|||/items/35e493b5-619e-4ff6-9e7a-22ed03cd9205ExosomesProbioticsMicroRNADysbiosisInflammationAkkermansia muciniphilaObesity and diabetes incidence rates are increasing dramatically, reaching pandemic proportions. Therefore, there is an urgent need to unravel the mechanisms underlying their pathophysiology. Of particular interest is the close interconnection between gut microbiota dysbiosis and obesity and diabetes progression. Hence, microbiota manipulation through diet has been postulated as a promising therapeutic target. In this regard, secretion of gut microbiota–derived extracellular vesicles is gaining special attention, standing out as key factors that could mediate gut microbiota-host communication. Extracellular vesicles (EVs) derived from gut microbiota and probiotic bacteria allow to encapsulate a wide range of bioactive molecules (such as/or including proteins and nucleic acids) that could travel short and long distances to modulate important biological functions with the overall impact on the host health. EV-derived from specific bacteria induce differential physiological responses. For example, a high-fat diet–induced increase of the proteobacterium Pseudomonas panacis–derived EV is closely associated with the progression of metabolic dysfunction in mice. In contrast, Akkermansia muciniphila EV are linked with the alleviation of high-fat diet–induced obesity and diabetes in mice. Here, we review the newest pieces of evidence concerning the potential role of gut microbiota and probiotic-derived EV on obesity and diabetes onset, progression, and management, through the modulation of inflammation, metabolism, and gut permeability. In addition, we discuss the role of certain dietary patterns on gut microbiota–derived EV profile and the clinical implication that dietary habits could have on metabolic diseases progression through the shaping of gut microbiota–derived EV.SpringerDadun. Depósito Académico Digital Universidad de Navarra20222022-08-0420222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63874reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/638742026-06-21T12:47:57Z
dc.title.none.fl_str_mv Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
title Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
spellingShingle Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
Díez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8
Exosomes
Probiotics
MicroRNA
Dysbiosis
Inflammation
Akkermansia muciniphila
title_short Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
title_full Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
title_fullStr Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
title_full_unstemmed Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
title_sort Effects of gut microbiota–derived extracellular vesicles on obesity and diabetes and their potential modulation through diet
dc.creator.none.fl_str_mv Díez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Lorente-Cebrian, S. (Silvia)|||/items/35e493b5-619e-4ff6-9e7a-22ed03cd9205
author Díez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8
author_facet Díez-Sainz, E. (Ester)|||/items/b7fb9712-8c82-47a6-9946-c6ef9c759ad8
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Lorente-Cebrian, S. (Silvia)|||/items/35e493b5-619e-4ff6-9e7a-22ed03cd9205
author_role author
author2 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Lorente-Cebrian, S. (Silvia)|||/items/35e493b5-619e-4ff6-9e7a-22ed03cd9205
author2_role author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Exosomes
Probiotics
MicroRNA
Dysbiosis
Inflammation
Akkermansia muciniphila
topic Exosomes
Probiotics
MicroRNA
Dysbiosis
Inflammation
Akkermansia muciniphila
description Obesity and diabetes incidence rates are increasing dramatically, reaching pandemic proportions. Therefore, there is an urgent need to unravel the mechanisms underlying their pathophysiology. Of particular interest is the close interconnection between gut microbiota dysbiosis and obesity and diabetes progression. Hence, microbiota manipulation through diet has been postulated as a promising therapeutic target. In this regard, secretion of gut microbiota–derived extracellular vesicles is gaining special attention, standing out as key factors that could mediate gut microbiota-host communication. Extracellular vesicles (EVs) derived from gut microbiota and probiotic bacteria allow to encapsulate a wide range of bioactive molecules (such as/or including proteins and nucleic acids) that could travel short and long distances to modulate important biological functions with the overall impact on the host health. EV-derived from specific bacteria induce differential physiological responses. For example, a high-fat diet–induced increase of the proteobacterium Pseudomonas panacis–derived EV is closely associated with the progression of metabolic dysfunction in mice. In contrast, Akkermansia muciniphila EV are linked with the alleviation of high-fat diet–induced obesity and diabetes in mice. Here, we review the newest pieces of evidence concerning the potential role of gut microbiota and probiotic-derived EV on obesity and diabetes onset, progression, and management, through the modulation of inflammation, metabolism, and gut permeability. In addition, we discuss the role of certain dietary patterns on gut microbiota–derived EV profile and the clinical implication that dietary habits could have on metabolic diseases progression through the shaping of gut microbiota–derived EV.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-04
2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/63874
url https://hdl.handle.net/10171/63874
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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