Development of the Binocular Circuit

Seeing in three dimensions is a major property of the visual system in mammals. The circuit underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend to the same or opposite side of the brain. RGC axons decussate to form the optic chiasm, then grow to targets in...

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Detalles Bibliográficos
Autores: Herrera, Eloisa, Chédotal, Alain, Mason, Carol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/379933
Acceso en línea:http://hdl.handle.net/10261/379933
https://api.elsevier.com/content/abstract/scopus_id/85206654314
Access Level:acceso abierto
Palabra clave:Axon targeting
Ciliary margin
Evolution
Optic chiasm
Retinal ganglion cell
Transcriptomics
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spelling Development of the Binocular CircuitHerrera, EloisaChédotal, AlainMason, CarolAxon targetingCiliary marginEvolutionOptic chiasmRetinal ganglion cellTranscriptomicsSeeing in three dimensions is a major property of the visual system in mammals. The circuit underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend to the same or opposite side of the brain. RGC axons decussate to form the optic chiasm, then grow to targets in the thalamus and midbrain, where they synapse with neurons that project to the visual cortex. Here we review the cellular and molecular mechanisms of RGC axonal growth cone guidance across or away from the midline via receptors to cues in the midline environment. We present new views on the specification of ipsi- and contralateral RGC subpopulations and factors implementing their organization in the optic tract and termination in subregions of their targets. Lastly, we describe the functional and behavioral aspects of binocular vision, focusing on the mouse, and discuss recent discoveries in the evolution of the binocular circuit.We thank Michel Cayouette for his input on our manuscript. The lab of E.H. is funded by grants from the Valencia Regional Government (PROMETEO/2020/007), the Spanish Government (PID2022-138245NB-I00), Fundacion La Caixa (HR21-00824), and Fundacion ICAR (CelMa-ENVEJECE) (E.H.). E.H.’s laboratory is at the Instituto de Neurociencias, Severo Ochoa Excellence Center CEX2021-001165-S. The laboratory of A.C. is supported by HU FOReSIGHT (ANR-18-IAHU-01). The laboratory of C.M. is supported by National Institutes of Health grants R01 EY015290 and R01 EY12736, an António Champalimaud Vision Award, a Simons Foundation Senior Fellow Award, the National Organization for Albinism and Hypopigmentation, and the Fight for Sight foundation.With funding from the Spanish government through the "Severo Ochoa Centre of Excelence" accreditation (CEX2021-001165-S)Peer reviewedAnnual ReviewsGeneralitat ValencianaAgencia Estatal de Investigación (España)Fundación la CaixaFundación ICARNational Institutes of Health (US)Simons Foundation Autism Research InitiativeNational Organization for Albinism and Hypopigmentation (US)Fight for Sight (UK)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/379933https://api.elsevier.com/content/abstract/scopus_id/85206654314reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001165-Sinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138245NB-I00https://doi.org/10.1146/annurev-neuro-111020-093230Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3799332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Development of the Binocular Circuit
title Development of the Binocular Circuit
spellingShingle Development of the Binocular Circuit
Herrera, Eloisa
Axon targeting
Ciliary margin
Evolution
Optic chiasm
Retinal ganglion cell
Transcriptomics
title_short Development of the Binocular Circuit
title_full Development of the Binocular Circuit
title_fullStr Development of the Binocular Circuit
title_full_unstemmed Development of the Binocular Circuit
title_sort Development of the Binocular Circuit
dc.creator.none.fl_str_mv Herrera, Eloisa
Chédotal, Alain
Mason, Carol
author Herrera, Eloisa
author_facet Herrera, Eloisa
Chédotal, Alain
Mason, Carol
author_role author
author2 Chédotal, Alain
Mason, Carol
author2_role author
author
dc.contributor.none.fl_str_mv Generalitat Valenciana
Agencia Estatal de Investigación (España)
Fundación la Caixa
Fundación ICAR
National Institutes of Health (US)
Simons Foundation Autism Research Initiative
National Organization for Albinism and Hypopigmentation (US)
Fight for Sight (UK)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Axon targeting
Ciliary margin
Evolution
Optic chiasm
Retinal ganglion cell
Transcriptomics
topic Axon targeting
Ciliary margin
Evolution
Optic chiasm
Retinal ganglion cell
Transcriptomics
description Seeing in three dimensions is a major property of the visual system in mammals. The circuit underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend to the same or opposite side of the brain. RGC axons decussate to form the optic chiasm, then grow to targets in the thalamus and midbrain, where they synapse with neurons that project to the visual cortex. Here we review the cellular and molecular mechanisms of RGC axonal growth cone guidance across or away from the midline via receptors to cues in the midline environment. We present new views on the specification of ipsi- and contralateral RGC subpopulations and factors implementing their organization in the optic tract and termination in subregions of their targets. Lastly, we describe the functional and behavioral aspects of binocular vision, focusing on the mouse, and discuss recent discoveries in the evolution of the binocular circuit.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/379933
https://api.elsevier.com/content/abstract/scopus_id/85206654314
url http://hdl.handle.net/10261/379933
https://api.elsevier.com/content/abstract/scopus_id/85206654314
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001165-S
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138245NB-I00
https://doi.org/10.1146/annurev-neuro-111020-093230
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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