Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets

Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and...

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Author: Domínguez Vivero, Clara
Format: doctoral thesis
Publication Date:2021
Country:España
Institution:Universidad de Santiago de Compostela (USC)
Repository:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Language:English
OAI Identifier:oai:minerva.usc.gal:10347/26289
Online Access:http://hdl.handle.net/10347/26289
Access Level:Open access
Keyword:Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
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spelling Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targetsDomínguez Vivero, ClaraMaterias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 NeurologíaMaterias::Investigación::32 Ciencias médicas::3207 Patología::320711 NeuropatologíaMigraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) is increased in chronic migraine (CM) patients, and if TLR4 is involved in the vascular response to CSD. With this aim, we designed a clinical cross-sectional study measuring peripheral blood expression of TLR2 and TLR4 and a experimental study based on an animal model of cortical spreading depolarization (CSD). CM patients showed increased expression of TLR4 and TLR2 in peripheral blood. TLR4 KO mice had a different response to CSD stimulation that was reproduced after pharmacological blockade of TLR4. Our results suggest that TLR2 and TLR4 may have a role in migraine pathophysiology, providing a potential novel strategy for treatment.Castillo Sánchez, José AntonioLeira Muiño, RogelioUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20212021-01-0120212021-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/26289reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/262892026-06-15T12:47:27Z
dc.title.none.fl_str_mv Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
spellingShingle Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
Domínguez Vivero, Clara
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
title_short Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_full Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_fullStr Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_full_unstemmed Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_sort Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
dc.creator.none.fl_str_mv Domínguez Vivero, Clara
author Domínguez Vivero, Clara
author_facet Domínguez Vivero, Clara
author_role author
dc.contributor.none.fl_str_mv Castillo Sánchez, José Antonio
Leira Muiño, Rogelio
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
topic Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
description Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) is increased in chronic migraine (CM) patients, and if TLR4 is involved in the vascular response to CSD. With this aim, we designed a clinical cross-sectional study measuring peripheral blood expression of TLR2 and TLR4 and a experimental study based on an animal model of cortical spreading depolarization (CSD). CM patients showed increased expression of TLR4 and TLR2 in peripheral blood. TLR4 KO mice had a different response to CSD stimulation that was reproduced after pharmacological blockade of TLR4. Our results suggest that TLR2 and TLR4 may have a role in migraine pathophysiology, providing a potential novel strategy for treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/26289
url http://hdl.handle.net/10347/26289
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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