Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure

The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium expos...

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Autores: Laurent, Olivier, Cardis, Elisabeth, Pernot, Eileen, Turner, Michelle C., Laurier, Dominique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/59151
Acceso en línea:http://hdl.handle.net/10230/59151
http://dx.doi.org/10.1088/0952-4746/36/2/319
Access Level:acceso abierto
Palabra clave:Uranium
Radionuclides
Dosimetry
Biomarkers
Molecular epidemiology
Epidemiology
Occupational exposure
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spelling Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposureLaurent, OlivierCardis, ElisabethPernot, EileenTurner, Michelle C.Laurier, DominiqueUraniumRadionuclidesDosimetryBiomarkersMolecular epidemiologyEpidemiologyOccupational exposureThe potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure. The aim of the European Commission concerted action CURE (Concerted Uranium Research in Europe) was to develop protocols for such a future collaborative research project, in which dosimetry, epidemiology and biology would be integrated to better characterize the effects of occupational uranium exposure. These protocols were developed from existing European cohorts of workers exposed to uranium together with expertise in epidemiology, biology and dosimetry of CURE partner institutions. The preparatory work of CURE should allow a large scale collaborative project to be launched, in order to better characterize the effects of uranium exposure and more generally of alpha particles and low doses of ionizing radiation.The CURE project was supported by the European Commission FP7 DoReMi Network of Excellence (grant number: 249689). MCT was funded by a Government of Canada Banting Postdoctoral Fellowship. PHE and Nuvia received partial funding from the UK Nuclear Decommissioning Authority. IRSN received partial funding from AREVA.IOP Publishing Ltd.202420242016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59151http://dx.doi.org/10.1088/0952-4746/36/2/319reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Radiological Protection. 2016 Jun;36(2):319-45info:eu-repo/grantAgreement/EC/FP7/249689Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.http://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/591512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
title Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
spellingShingle Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
Laurent, Olivier
Uranium
Radionuclides
Dosimetry
Biomarkers
Molecular epidemiology
Epidemiology
Occupational exposure
title_short Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
title_full Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
title_fullStr Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
title_full_unstemmed Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
title_sort Concerted uranium research in Europe (CURE): toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure
dc.creator.none.fl_str_mv Laurent, Olivier
Cardis, Elisabeth
Pernot, Eileen
Turner, Michelle C.
Laurier, Dominique
author Laurent, Olivier
author_facet Laurent, Olivier
Cardis, Elisabeth
Pernot, Eileen
Turner, Michelle C.
Laurier, Dominique
author_role author
author2 Cardis, Elisabeth
Pernot, Eileen
Turner, Michelle C.
Laurier, Dominique
author2_role author
author
author
author
dc.subject.none.fl_str_mv Uranium
Radionuclides
Dosimetry
Biomarkers
Molecular epidemiology
Epidemiology
Occupational exposure
topic Uranium
Radionuclides
Dosimetry
Biomarkers
Molecular epidemiology
Epidemiology
Occupational exposure
description The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure. The aim of the European Commission concerted action CURE (Concerted Uranium Research in Europe) was to develop protocols for such a future collaborative research project, in which dosimetry, epidemiology and biology would be integrated to better characterize the effects of occupational uranium exposure. These protocols were developed from existing European cohorts of workers exposed to uranium together with expertise in epidemiology, biology and dosimetry of CURE partner institutions. The preparatory work of CURE should allow a large scale collaborative project to be launched, in order to better characterize the effects of uranium exposure and more generally of alpha particles and low doses of ionizing radiation.
publishDate 2016
dc.date.none.fl_str_mv 2016
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59151
http://dx.doi.org/10.1088/0952-4746/36/2/319
url http://hdl.handle.net/10230/59151
http://dx.doi.org/10.1088/0952-4746/36/2/319
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Radiological Protection. 2016 Jun;36(2):319-45
info:eu-repo/grantAgreement/EC/FP7/249689
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing Ltd.
publisher.none.fl_str_mv IOP Publishing Ltd.
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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