Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations
Auditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories. We have recruited 41 p...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:303851 |
| Acesso em linha: | https://ddd.uab.cat/record/303851 https://dx.doi.org/urn:doi:10.1016/j.rpsm.2023.05.002 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Amygdala Auditory hallucinations Hippocampus Schizophrenia Segmentation |
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Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinationsPerez-Rando, Marta|||0000-0002-5286-1545Penades-Gomiz, CarlotaMartinez-Marin, PabloGarcía-Martí, Gracián|||0000-0002-9850-2580Aguilar Cortes, Eduardo|||0000-0002-7875-5644Escarti, Maria J.Grasa, Eva|||0000-0003-1100-7489Corripio, Iluminada|||0000-0003-2562-711XSanjuan, JulioNacher, Juan|||0000-0001-7599-3957AmygdalaAuditory hallucinationsHippocampusSchizophreniaSegmentationAuditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories. We have recruited 41 patients with schizophrenia and persistent AH, 35 patients without AH, and 55 healthy controls. Using their MRIs, we have performed semiautomatic segmentations of the hippocampus and amygdala using Freesurfer. We have also performed bilateral correlations between the total PSYRATS score and the volumes of affected subregions and nuclei. In the hippocampus, we found bilateral increases in the volume of its hippocampal fissure and decreases in the right fimbria in patients with and without AH. The volume of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus were decreased in patients with AH. In the amygdala, we found its left total volume was shrunk, and there was a decrease of its left accessory basal nucleus in patients with AH. We have detected volume alterations of different limbic structures likely due to the presence of AH. The volumes of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus, and total volume of the amygdala and its accessory basal nucleus, were only affected in patients with AH. Bilateral volume alterations in the hippocampal fissure and right fimbria seem inherent of schizophrenia and due to traits not contemplated in our research.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/303851https://dx.doi.org/urn:doi:10.1016/j.rpsm.2023.05.002reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00473open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3038512026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| title |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| spellingShingle |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations Perez-Rando, Marta|||0000-0002-5286-1545 Amygdala Auditory hallucinations Hippocampus Schizophrenia Segmentation |
| title_short |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| title_full |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| title_fullStr |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| title_full_unstemmed |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| title_sort |
Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations |
| dc.creator.none.fl_str_mv |
Perez-Rando, Marta|||0000-0002-5286-1545 Penades-Gomiz, Carlota Martinez-Marin, Pablo García-Martí, Gracián|||0000-0002-9850-2580 Aguilar Cortes, Eduardo|||0000-0002-7875-5644 Escarti, Maria J. Grasa, Eva|||0000-0003-1100-7489 Corripio, Iluminada|||0000-0003-2562-711X Sanjuan, Julio Nacher, Juan|||0000-0001-7599-3957 |
| author |
Perez-Rando, Marta|||0000-0002-5286-1545 |
| author_facet |
Perez-Rando, Marta|||0000-0002-5286-1545 Penades-Gomiz, Carlota Martinez-Marin, Pablo García-Martí, Gracián|||0000-0002-9850-2580 Aguilar Cortes, Eduardo|||0000-0002-7875-5644 Escarti, Maria J. Grasa, Eva|||0000-0003-1100-7489 Corripio, Iluminada|||0000-0003-2562-711X Sanjuan, Julio Nacher, Juan|||0000-0001-7599-3957 |
| author_role |
author |
| author2 |
Penades-Gomiz, Carlota Martinez-Marin, Pablo García-Martí, Gracián|||0000-0002-9850-2580 Aguilar Cortes, Eduardo|||0000-0002-7875-5644 Escarti, Maria J. Grasa, Eva|||0000-0003-1100-7489 Corripio, Iluminada|||0000-0003-2562-711X Sanjuan, Julio Nacher, Juan|||0000-0001-7599-3957 |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Amygdala Auditory hallucinations Hippocampus Schizophrenia Segmentation |
| topic |
Amygdala Auditory hallucinations Hippocampus Schizophrenia Segmentation |
| description |
Auditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories. We have recruited 41 patients with schizophrenia and persistent AH, 35 patients without AH, and 55 healthy controls. Using their MRIs, we have performed semiautomatic segmentations of the hippocampus and amygdala using Freesurfer. We have also performed bilateral correlations between the total PSYRATS score and the volumes of affected subregions and nuclei. In the hippocampus, we found bilateral increases in the volume of its hippocampal fissure and decreases in the right fimbria in patients with and without AH. The volume of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus were decreased in patients with AH. In the amygdala, we found its left total volume was shrunk, and there was a decrease of its left accessory basal nucleus in patients with AH. We have detected volume alterations of different limbic structures likely due to the presence of AH. The volumes of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus, and total volume of the amygdala and its accessory basal nucleus, were only affected in patients with AH. Bilateral volume alterations in the hippocampal fissure and right fimbria seem inherent of schizophrenia and due to traits not contemplated in our research. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/303851 https://dx.doi.org/urn:doi:10.1016/j.rpsm.2023.05.002 |
| url |
https://ddd.uab.cat/record/303851 https://dx.doi.org/urn:doi:10.1016/j.rpsm.2023.05.002 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00473 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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