A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice

Depending on its anatomical placement, perivascular adipose tissue (PVAT) has been found to possess features more (e.g., aortic thoracic) or less (e.g., aortic abdominal) similar to brown/beige adipose tissue in mice, whereas PVAT surrounding the mesenteric arteries and the caudal part of abdominal...

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Authors: Mestres Arenas, Alberto, Villarroya, Joan, Giralt i Oms, Marta, Villarroya i Gombau, Francesc, Peyrou, Marion
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/196764
Online Access:https://hdl.handle.net/2445/196764
Access Level:Open access
Keyword:Fisiologia
Teixit adipós
Physiology
Adipose tissues
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spelling A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From MiceMestres Arenas, AlbertoVillarroya, JoanGiralt i Oms, MartaVillarroya i Gombau, FrancescPeyrou, MarionFisiologiaTeixit adipósPhysiologyAdipose tissuesDepending on its anatomical placement, perivascular adipose tissue (PVAT) has been found to possess features more (e.g., aortic thoracic) or less (e.g., aortic abdominal) similar to brown/beige adipose tissue in mice, whereas PVAT surrounding the mesenteric arteries and the caudal part of abdominal aorta is similar to white fat. PVAT is thought to influence vascular function through the effects of adipose-secreted molecules on vessels. Brown adipose tissue was recently shown to play differential secretory role via secretion of the so-called batokines but the involvement of differential batokine production in PVAT brown/ beige plasticity was unclear. The current study characterizes for the first time the expression of batokines at aortic thoracic PVAT (tPVAT) and aortic abdominal PVAT (aPVAT) in comparison with typical brown and white adipose depots, in basal and thermogenically activated conditions. We found that both PVAT depots increased their expression of genes encoding the batokines bone morphogenetic protein-8b (BMP8B), fibroblast growth factor-21 (FGF21), and kininogen-2 (KNG2) in response to cold, indicating that, under cold-induced thermogenic activation, both thoracic aorta and abdominal aorta would experience intense local exposure to these PVAT-secreted batokines. In contrast, the gene expression levels of growth/differentiation factor-15 and vascular endothelial growth factor-A were induced only in tPVAT. Under short-term high-fat diet-induced thermogenic activation, the thoracic aorta would be specifically exposed to a local increase in PVAToriginating BMP8B, FGF21, and KNG2. Our data support the notion that acquisition of a brown/beige phenotype in PVAT is associated with upregulation of batokines, mainly BMP8B, FGF21, and KNG2, that can differentially target the vascular system.Frontiers Media2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/196764Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fphys.2021.714530Frontiers in Physiology, 2021, vol. 12, p. 714530https://doi.org/10.3389/fphys.2021.714530cc-by (c) Mestres Arenas, Alberto et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1967642026-05-27T06:46:51Z
dc.title.none.fl_str_mv A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
title A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
spellingShingle A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
Mestres Arenas, Alberto
Fisiologia
Teixit adipós
Physiology
Adipose tissues
title_short A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
title_full A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
title_fullStr A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
title_full_unstemmed A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
title_sort A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice
dc.creator.none.fl_str_mv Mestres Arenas, Alberto
Villarroya, Joan
Giralt i Oms, Marta
Villarroya i Gombau, Francesc
Peyrou, Marion
author Mestres Arenas, Alberto
author_facet Mestres Arenas, Alberto
Villarroya, Joan
Giralt i Oms, Marta
Villarroya i Gombau, Francesc
Peyrou, Marion
author_role author
author2 Villarroya, Joan
Giralt i Oms, Marta
Villarroya i Gombau, Francesc
Peyrou, Marion
author2_role author
author
author
author
dc.subject.none.fl_str_mv Fisiologia
Teixit adipós
Physiology
Adipose tissues
topic Fisiologia
Teixit adipós
Physiology
Adipose tissues
description Depending on its anatomical placement, perivascular adipose tissue (PVAT) has been found to possess features more (e.g., aortic thoracic) or less (e.g., aortic abdominal) similar to brown/beige adipose tissue in mice, whereas PVAT surrounding the mesenteric arteries and the caudal part of abdominal aorta is similar to white fat. PVAT is thought to influence vascular function through the effects of adipose-secreted molecules on vessels. Brown adipose tissue was recently shown to play differential secretory role via secretion of the so-called batokines but the involvement of differential batokine production in PVAT brown/ beige plasticity was unclear. The current study characterizes for the first time the expression of batokines at aortic thoracic PVAT (tPVAT) and aortic abdominal PVAT (aPVAT) in comparison with typical brown and white adipose depots, in basal and thermogenically activated conditions. We found that both PVAT depots increased their expression of genes encoding the batokines bone morphogenetic protein-8b (BMP8B), fibroblast growth factor-21 (FGF21), and kininogen-2 (KNG2) in response to cold, indicating that, under cold-induced thermogenic activation, both thoracic aorta and abdominal aorta would experience intense local exposure to these PVAT-secreted batokines. In contrast, the gene expression levels of growth/differentiation factor-15 and vascular endothelial growth factor-A were induced only in tPVAT. Under short-term high-fat diet-induced thermogenic activation, the thoracic aorta would be specifically exposed to a local increase in PVAToriginating BMP8B, FGF21, and KNG2. Our data support the notion that acquisition of a brown/beige phenotype in PVAT is associated with upregulation of batokines, mainly BMP8B, FGF21, and KNG2, that can differentially target the vascular system.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/196764
url https://hdl.handle.net/2445/196764
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fphys.2021.714530
Frontiers in Physiology, 2021, vol. 12, p. 714530
https://doi.org/10.3389/fphys.2021.714530
dc.rights.none.fl_str_mv cc-by (c) Mestres Arenas, Alberto et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mestres Arenas, Alberto et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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