Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Producción Científica

Detalhes bibliográficos
Autores: Lamo-Espinosa, José María, Prósper, Felipe, Blanco, Juan Francisco, Sánchez Guijo, Fermín, Alberca Zaballos, María Mercedes, García Diaz, Verónica, González-Vallinas Garrachón, Margarita, García-Sancho Martín, Francisco Javier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/82008
Acesso em linha:https://doi.org/10.1186/s12967-021-03160-2
https://uvadoc.uva.es/handle/10324/82008
Access Level:acceso abierto
Palavra-chave:Intraarticular injection
Mesenchymal stem cells
Osteoarthritis
Regenerative medicine
Stem cell therapy
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spelling Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritisLamo-Espinosa, José MaríaPrósper, FelipeBlanco, Juan FranciscoSánchez Guijo, FermínAlberca Zaballos, María MercedesGarcía Diaz, VerónicaGonzález-Vallinas Garrachón, MargaritaGarcía-Sancho Martín, Francisco JavierIntraarticular injectionMesenchymal stem cellsOsteoarthritisRegenerative medicineStem cell therapyProducción CientíficaKnee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014-Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1.This work was supported by Red de Terapia Celular of Instituto de Salud Carlos III (RETIC TerCel, RD16/0011/0003, 0005, and 0015; PIC18/00001), Centro en Red de Medicina Regenerativa de Castilla y León, and Programa Estratégico Instituto de Biología y Genética Molecular (IBGM), Escalera de Excelencia, Junta de Castilla y León (Ref. CLU-2019-02). The European Union co-financed these grants through the European Regional Development Fund. M.G.V. was supported by a Juan de la Cierva Incorporation Fellowship.BioMed Central (BMC)2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1186/s12967-021-03160-2https://uvadoc.uva.es/handle/10324/82008reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://link.springer.com/article/10.1186/s12967-021-03160-2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/820082026-06-13T12:44:47Z
dc.title.none.fl_str_mv Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
title Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
spellingShingle Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
Lamo-Espinosa, José María
Intraarticular injection
Mesenchymal stem cells
Osteoarthritis
Regenerative medicine
Stem cell therapy
title_short Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
title_full Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
title_fullStr Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
title_full_unstemmed Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
title_sort Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
dc.creator.none.fl_str_mv Lamo-Espinosa, José María
Prósper, Felipe
Blanco, Juan Francisco
Sánchez Guijo, Fermín
Alberca Zaballos, María Mercedes
García Diaz, Verónica
González-Vallinas Garrachón, Margarita
García-Sancho Martín, Francisco Javier
author Lamo-Espinosa, José María
author_facet Lamo-Espinosa, José María
Prósper, Felipe
Blanco, Juan Francisco
Sánchez Guijo, Fermín
Alberca Zaballos, María Mercedes
García Diaz, Verónica
González-Vallinas Garrachón, Margarita
García-Sancho Martín, Francisco Javier
author_role author
author2 Prósper, Felipe
Blanco, Juan Francisco
Sánchez Guijo, Fermín
Alberca Zaballos, María Mercedes
García Diaz, Verónica
González-Vallinas Garrachón, Margarita
García-Sancho Martín, Francisco Javier
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Intraarticular injection
Mesenchymal stem cells
Osteoarthritis
Regenerative medicine
Stem cell therapy
topic Intraarticular injection
Mesenchymal stem cells
Osteoarthritis
Regenerative medicine
Stem cell therapy
description Producción Científica
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s12967-021-03160-2
https://uvadoc.uva.es/handle/10324/82008
url https://doi.org/10.1186/s12967-021-03160-2
https://uvadoc.uva.es/handle/10324/82008
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://link.springer.com/article/10.1186/s12967-021-03160-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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