Ca2+ mishandling in heart failure: Potential targets

Ca2+ mishandling is a common feature in several cardiovascular diseases such as heart failure (HF). In many cases, impairment of key players in intracellular Ca2+ homeostasis has been identified as the underlying mechanism of cardiac dysfunction and cardiac arrhythmias associated with HF. In this re...

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Autores: Val-Blasco, Almudena, Gil-Fernández, Marta, Rueda, Angélica, Pereira, Laetitia, Delgado, Carmen, Smani, Tarik, Ruiz-Hurtado, Gema, Fernández-Velasco, María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/264859
Acceso en línea:http://hdl.handle.net/10261/264859
Access Level:acceso abierto
Palabra clave:Calcium handling
EC coupling
Heart failure
Ryanodine
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spelling Ca2+ mishandling in heart failure: Potential targetsVal-Blasco, AlmudenaGil-Fernández, MartaRueda, AngélicaPereira, LaetitiaDelgado, CarmenSmani, TarikRuiz-Hurtado, GemaFernández-Velasco, MaríaCalcium handlingEC couplingHeart failureRyanodineCa2+ mishandling is a common feature in several cardiovascular diseases such as heart failure (HF). In many cases, impairment of key players in intracellular Ca2+ homeostasis has been identified as the underlying mechanism of cardiac dysfunction and cardiac arrhythmias associated with HF. In this review, we summarize primary novel findings related to Ca2+ mishandling in HF progression. HF research has increasingly focused on the identification of new targets and the contribution of their role in Ca2+ handling to the progression of the disease. Recent research studies have identified potential targets in three major emerging areas implicated in regulation of Ca2+ handling: the innate immune system, bone metabolism factors and post-translational modification of key proteins involved in regulation of Ca2+ handling. Here, we describe their possible contributions to the progression of HF.This work was supported by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund (SAF-2017-84777R), Institute of Health Carlos III (PI17/01093, PI20/01482 and PI17/01344), Sociedad Española de Cardiología, Proyecto Traslacional 2019, PI3110 Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Fondo Europeo de Desarrollo Regional (FEDER), FSE, and CIBER-CV, a network funded by ISCIII. MF-V is Miguel Servet II researcher of ISCIII (MSII16/00047 Carlos III Health Institute). GR-H is Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). AR was supported by Fondo SEP-Cinvestav project # 601410 FIDSC 2018/2; and Fondo SEP-Conacyt Ciencia Básica A1-S-9082. LP is supported by Institut de France Bourse Lefoulon Delaland.John Wiley & SonsMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIISociedad Española de CardiologíaFundación Renal Íñigo Álvarez de ToledoEuropean CommissionInstitut de FranceConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPostprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/264859reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-84777-Rhttp://dx.doi.org/10.1111/apha.13691Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2648592026-05-22T06:33:51Z
dc.title.none.fl_str_mv Ca2+ mishandling in heart failure: Potential targets
title Ca2+ mishandling in heart failure: Potential targets
spellingShingle Ca2+ mishandling in heart failure: Potential targets
Val-Blasco, Almudena
Calcium handling
EC coupling
Heart failure
Ryanodine
title_short Ca2+ mishandling in heart failure: Potential targets
title_full Ca2+ mishandling in heart failure: Potential targets
title_fullStr Ca2+ mishandling in heart failure: Potential targets
title_full_unstemmed Ca2+ mishandling in heart failure: Potential targets
title_sort Ca2+ mishandling in heart failure: Potential targets
dc.creator.none.fl_str_mv Val-Blasco, Almudena
Gil-Fernández, Marta
Rueda, Angélica
Pereira, Laetitia
Delgado, Carmen
Smani, Tarik
Ruiz-Hurtado, Gema
Fernández-Velasco, María
author Val-Blasco, Almudena
author_facet Val-Blasco, Almudena
Gil-Fernández, Marta
Rueda, Angélica
Pereira, Laetitia
Delgado, Carmen
Smani, Tarik
Ruiz-Hurtado, Gema
Fernández-Velasco, María
author_role author
author2 Gil-Fernández, Marta
Rueda, Angélica
Pereira, Laetitia
Delgado, Carmen
Smani, Tarik
Ruiz-Hurtado, Gema
Fernández-Velasco, María
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Sociedad Española de Cardiología
Fundación Renal Íñigo Álvarez de Toledo
European Commission
Institut de France
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Calcium handling
EC coupling
Heart failure
Ryanodine
topic Calcium handling
EC coupling
Heart failure
Ryanodine
description Ca2+ mishandling is a common feature in several cardiovascular diseases such as heart failure (HF). In many cases, impairment of key players in intracellular Ca2+ homeostasis has been identified as the underlying mechanism of cardiac dysfunction and cardiac arrhythmias associated with HF. In this review, we summarize primary novel findings related to Ca2+ mishandling in HF progression. HF research has increasingly focused on the identification of new targets and the contribution of their role in Ca2+ handling to the progression of the disease. Recent research studies have identified potential targets in three major emerging areas implicated in regulation of Ca2+ handling: the innate immune system, bone metabolism factors and post-translational modification of key proteins involved in regulation of Ca2+ handling. Here, we describe their possible contributions to the progression of HF.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/264859
url http://hdl.handle.net/10261/264859
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-84777-R
http://dx.doi.org/10.1111/apha.13691
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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