Diffusivity estimation for activator–inhibitor models: theory and application to intracellular dynamics of the actin cytoskeleton

A theory for diffusivity estimation for spatially extended activator–inhibitor dynamics modeling the evolution of intracellular signaling networks is developed in the math- ematical framework of stochastic reaction–diffusion systems. In order to account for model uncertainties, we extend the results...

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Detalles Bibliográficos
Autores: Flemming, Sven, Alonso Muñoz, Sergio|||0000-0002-3989-8757, Beta, Carsten
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/359850
Acceso en línea:https://hdl.handle.net/2117/359850
https://dx.doi.org/10.1007/s00332-021-09714-4
Access Level:acceso abierto
Palabra clave:Cytoskeleton
Parametric drift estimation
Stochastic reaction–diffusion systems
Maximum likelihood estimation
Actin cytoskeleton dynamics
Difusió (Física)
Àrees temàtiques de la UPC::Física::Física molecular::Espectroscòpia molecular
Descripción
Sumario:A theory for diffusivity estimation for spatially extended activator–inhibitor dynamics modeling the evolution of intracellular signaling networks is developed in the math- ematical framework of stochastic reaction–diffusion systems. In order to account for model uncertainties, we extend the results for parameter estimation for semilinear stochastic partial differential equations