New insights about the intercalation of 5-Fluorouracil into 2D Mg–Al layered double hydroxide nanosheets: A theoretical and experimental investigation
Layered double hydroxides (LDH) are interesting 2D inorganic platforms for biomedical purposes. In contrast to previous studies, this work reports the intercalation of 5-Fluorouracil (5-FU) into LDH through anion exchange using a fresh LDH material without the need for any organic compound or treatm...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/358055 |
| Acceso en línea: | http://hdl.handle.net/10261/358055 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148754546&doi=10.1016%2fj.jddst.2023.104294&partnerID=40&md5=6b6824caa96718301745b538e7b15330 |
| Access Level: | acceso abierto |
| Palabra clave: | 5-Fluorouraci Layered double hydroxide Anion exchange reaction Theoretical studies Drug delivery system |
| Sumario: | Layered double hydroxides (LDH) are interesting 2D inorganic platforms for biomedical purposes. In contrast to previous studies, this work reports the intercalation of 5-Fluorouracil (5-FU) into LDH through anion exchange using a fresh LDH material without the need for any organic compound or treatment prior to the intercalation with 5-FU. The combination of experimental charaterizations and computational studies allowed us to study the intercalation process, where the presence of three phases in the hybrid material are suggested: two of them are related to different charge states of the intercalated 5-FU into 2D LDH interlayer space, and the third one might be related to some kind of distorted LDH. FTIR, XPS and DFT calculations indicated that interactions established in the host-guest system involve a complex network of hydrogen bonds, contributing to the improvement of the chemical and thermal stability of the 5-FU-LDH hybrid. Release assays of 5-FU from the 5-FU-LDH demonstrated the ability to selectively release the drug in simulated tumor microenvironment, while in vitro bioassays suggested a dose-dependent behavior of the hybrid. These results contribute to a better understanding of the chemistry of intercalation of 5-FU into 2D-LDH, and can be used to tune properties of 5-FU-LDH in antitumor therapy. © 2023 Elsevier B.V. |
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