Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management

Essential tremor (ET) is a highly prevalent neurological disorder characterized by action- induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance e...

ver descrição completa

Detalhes bibliográficos
Autores: Lopez-de-Ipina, Karmele, Solé-Casals, Jordi, Sánchez-Méndez, José Ignacio, Romero García, Rafael, Fernandez, Elsa, Requejo, Catalina, Suckling, John
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/137426
Acesso em linha:https://hdl.handle.net/11441/137426
https://doi.org/10.3389/fnhum.2021.648573
Access Level:Acceso aberto
Palavra-chave:Essential tremor
Fine motor skills
Neuroimaging
Handwriting
Early managemen
id ES_a56bc85afdbf8d093e11c6d55962a474
oai_identifier_str oai:idus.us.es:11441/137426
network_acronym_str ES
network_name_str España
repository_id_str
spelling Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early ManagementLopez-de-Ipina, KarmeleSolé-Casals, JordiSánchez-Méndez, José IgnacioRomero García, RafaelFernandez, ElsaRequejo, CatalinaSuckling, JohnEssential tremorFine motor skillsNeuroimagingHandwritingEarly managemenEssential tremor (ET) is a highly prevalent neurological disorder characterized by action- induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance early diagnostic approaches for ET, automated handwriting tasks and magnetic resonance imaging (MRI) offer an opportunity to develop early essential clinical biomarkers. In this study, we present a novel approach for the early clinical diagnosis and monitoring of ET based on integrating handwriting and neuroimaging analysis. We demonstrate how the analysis of fine motor skills, as measured by an automated Archimedes’ spiral task, is correlated with neuroimaging biomarkers for ET. Together, we present a novel modeling approach that can serve as a complementary and promising support tool for the clinical diagnosis of ET and a large range of tremors.Ministerio de Ciencia e Innovación SAF2016 77758 RFrontiers Research FoundationFisiología Médica y Biofísica2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/137426https://doi.org/10.3389/fnhum.2021.648573reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Immunology, 15, 1-11.http://doi.org/10.3389/fnhum.2021.648573info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1374262026-06-17T12:51:07Z
dc.title.none.fl_str_mv Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
title Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
spellingShingle Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
Lopez-de-Ipina, Karmele
Essential tremor
Fine motor skills
Neuroimaging
Handwriting
Early managemen
title_short Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
title_full Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
title_fullStr Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
title_full_unstemmed Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
title_sort Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management
dc.creator.none.fl_str_mv Lopez-de-Ipina, Karmele
Solé-Casals, Jordi
Sánchez-Méndez, José Ignacio
Romero García, Rafael
Fernandez, Elsa
Requejo, Catalina
Suckling, John
author Lopez-de-Ipina, Karmele
author_facet Lopez-de-Ipina, Karmele
Solé-Casals, Jordi
Sánchez-Méndez, José Ignacio
Romero García, Rafael
Fernandez, Elsa
Requejo, Catalina
Suckling, John
author_role author
author2 Solé-Casals, Jordi
Sánchez-Méndez, José Ignacio
Romero García, Rafael
Fernandez, Elsa
Requejo, Catalina
Suckling, John
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv Essential tremor
Fine motor skills
Neuroimaging
Handwriting
Early managemen
topic Essential tremor
Fine motor skills
Neuroimaging
Handwriting
Early managemen
description Essential tremor (ET) is a highly prevalent neurological disorder characterized by action- induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance early diagnostic approaches for ET, automated handwriting tasks and magnetic resonance imaging (MRI) offer an opportunity to develop early essential clinical biomarkers. In this study, we present a novel approach for the early clinical diagnosis and monitoring of ET based on integrating handwriting and neuroimaging analysis. We demonstrate how the analysis of fine motor skills, as measured by an automated Archimedes’ spiral task, is correlated with neuroimaging biomarkers for ET. Together, we present a novel modeling approach that can serve as a complementary and promising support tool for the clinical diagnosis of ET and a large range of tremors.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/137426
https://doi.org/10.3389/fnhum.2021.648573
url https://hdl.handle.net/11441/137426
https://doi.org/10.3389/fnhum.2021.648573
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Immunology, 15, 1-11.
http://doi.org/10.3389/fnhum.2021.648573
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415613306241024
score 15,301603

Registros relacionados