Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis

Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic valu...

Descripción completa

Detalles Bibliográficos
Autores: Hegen, Harald, Walde, Janette|||0000-0002-1241-5292, Berek, Klaus|||0000-0003-2755-2043, Arrambide, Georgina|||0000-0002-2657-5510, Gnanapavan, Sharmilee|||0000-0003-2817-9922, Kaplan, Batia, Khalil, Michael|||0000-0002-5350-3328, Saadeh, Ruba, Teunissen, Charlotte E|||0000-0002-4061-0837, Tumani, Hayrettin|||0000-0002-1647-6201, Villar, Luisa M|||0000-0002-9067-3668, Willrich, Maria Alice V, Zetterberg, Henrik|||0000-0003-3930-4354, Deisenhammer, Florian|||0000-0003-4541-8841
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:273252
Acceso en línea:https://ddd.uab.cat/record/273252
https://dx.doi.org/urn:doi:10.1177/13524585221134213
Access Level:acceso abierto
Palabra clave:Cerebrospinal fluid
Kappa free light chains
Multiple sclerosis
Clinically isolated syndrome
Diagnosis
Biomarker
Index
Intrathecal fraction
Meta-analysis
Systematic review
Descripción
Sumario:Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. PubMed was searched for studies that assessed diagnostic sensitivity and specificity of κ-FLC index and OCB to discriminate CIS/MS patients from control subjects. Two reviewers following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines performed study eligibility assessment and data extraction. Findings from studies were analyzed with bivariate mixed models. A total of 32 studies were included in the meta-analysis to evaluate diagnostic value of κ-FLC index. Sensitivity and specificity ranged from 52% to 100% (weighted average: 88%) and 69% to 100% (89%) for κ-FLC index and from 37% to 100% (85%) and 74% to 100% (92%) for OCB. Mean difference of sensitivity and specificity between κ-FLC index and OCB was 2 and -4 percentage points. Diagnostic accuracy determined by mixed models revealed no significant difference between κ-FLC index and OCB. A discriminatory cut-off for κ-FLC index was determined at 6.1. The findings indicate that κ-FLC index has similar diagnostic accuracy in MS as OCB

Similares en LA Referencia