ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/671590 |
| Acceso en línea: | http://hdl.handle.net/10486/671590 https://dx.doi.org/10.18632/oncotarget.3130 |
| Access Level: | acceso abierto |
| Palabra clave: | Colon cancer Lipid metabolism Biomarker Prognosis Medicina |
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ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patientsVargas, TeodoroMoreno-Rubio, JuanHerranz Barrera, JesúsCejas, PalomaMolina, SusanaGonzález-Vallinas, MargaritaMendiola, MartaBurgos, EmilioAguayo, CristinaCustodio, Ana B.Machado, IsidroRamos, DavidGironella, MeritxellEspinosa-Salinas, IsabelRamos, RicardoMartín-Hernández, RobertoRisueño, AlbertoLas Rivas, Javier deReglero Rada, Guillermo J.Yaya, RicardoFernández-Martos, CarlosAparicio, JorgeMaurel, JoanFeliú Batlle, JaimeRamírez de Molina, AnaColon cancerLipid metabolismBiomarkerPrognosisMedicinaLipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with strong statistical power in the four independent groups of patients. The identification of a group of 4 genes that predict survival in intermediate-stage colon cancer patients allows delineation of a high-risk group that may benefit from adjuvant therapy, and avoids the toxic and unnecessary chemotherapy in patients classified as low-risk groupThis work was supported by Ministerio de Ciencia e Innovación del Gobierno de España (Plan Nacional I + D + i AGL2013–48943-C2–2-R and IPT-2011–1248-060000), Comunidad de Madrid (P2013/ABI-2728. ALIBIRDCM) and European Union Structural Funds. CIBEREHD is funded by the Instituto de Salud Carlos III. This is a collaborative study between the Molecular Oncology Unit of The Institute of Advanced Studies of Madrid IMDEA Food and the Grupo Español Multidisciplinar en Cáncer Digestivo (GEMCAD)Impact JournalsDepartamento de MedicinaDepartamento de BioquímicaDepartamento de Química Física AplicadaFacultad de MedicinaInstituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ)20152015-02-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/671590https://dx.doi.org/10.18632/oncotarget.3130reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6715902026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| title |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| spellingShingle |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients Vargas, Teodoro Colon cancer Lipid metabolism Biomarker Prognosis Medicina |
| title_short |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| title_full |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| title_fullStr |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| title_full_unstemmed |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| title_sort |
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients |
| dc.creator.none.fl_str_mv |
Vargas, Teodoro Moreno-Rubio, Juan Herranz Barrera, Jesús Cejas, Paloma Molina, Susana González-Vallinas, Margarita Mendiola, Marta Burgos, Emilio Aguayo, Cristina Custodio, Ana B. Machado, Isidro Ramos, David Gironella, Meritxell Espinosa-Salinas, Isabel Ramos, Ricardo Martín-Hernández, Roberto Risueño, Alberto Las Rivas, Javier de Reglero Rada, Guillermo J. Yaya, Ricardo Fernández-Martos, Carlos Aparicio, Jorge Maurel, Joan Feliú Batlle, Jaime Ramírez de Molina, Ana |
| author |
Vargas, Teodoro |
| author_facet |
Vargas, Teodoro Moreno-Rubio, Juan Herranz Barrera, Jesús Cejas, Paloma Molina, Susana González-Vallinas, Margarita Mendiola, Marta Burgos, Emilio Aguayo, Cristina Custodio, Ana B. Machado, Isidro Ramos, David Gironella, Meritxell Espinosa-Salinas, Isabel Ramos, Ricardo Martín-Hernández, Roberto Risueño, Alberto Las Rivas, Javier de Reglero Rada, Guillermo J. Yaya, Ricardo Fernández-Martos, Carlos Aparicio, Jorge Maurel, Joan Feliú Batlle, Jaime Ramírez de Molina, Ana |
| author_role |
author |
| author2 |
Moreno-Rubio, Juan Herranz Barrera, Jesús Cejas, Paloma Molina, Susana González-Vallinas, Margarita Mendiola, Marta Burgos, Emilio Aguayo, Cristina Custodio, Ana B. Machado, Isidro Ramos, David Gironella, Meritxell Espinosa-Salinas, Isabel Ramos, Ricardo Martín-Hernández, Roberto Risueño, Alberto Las Rivas, Javier de Reglero Rada, Guillermo J. Yaya, Ricardo Fernández-Martos, Carlos Aparicio, Jorge Maurel, Joan Feliú Batlle, Jaime Ramírez de Molina, Ana |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Departamento de Bioquímica Departamento de Química Física Aplicada Facultad de Medicina Instituto de Investigación Sanitaria del Hospital Universitario de La Paz (IdiPAZ) |
| dc.subject.none.fl_str_mv |
Colon cancer Lipid metabolism Biomarker Prognosis Medicina |
| topic |
Colon cancer Lipid metabolism Biomarker Prognosis Medicina |
| description |
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to accurately stratify stage II colon cancer patients with 5-fold higher risk of relapse with strong statistical power in the four independent groups of patients. The identification of a group of 4 genes that predict survival in intermediate-stage colon cancer patients allows delineation of a high-risk group that may benefit from adjuvant therapy, and avoids the toxic and unnecessary chemotherapy in patients classified as low-risk group |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-02-06 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/671590 https://dx.doi.org/10.18632/oncotarget.3130 |
| url |
http://hdl.handle.net/10486/671590 https://dx.doi.org/10.18632/oncotarget.3130 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Impact Journals |
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Impact Journals |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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