Unequal impact of respiratory syncytial virus immunization in patients attending Spanish pediatric emergency departments
Objectives. To evaluate the impact of respiratory syncytial virus (RSV) prophylaxis with nirsevimab during its 2nd year of administration and analyze the differences between the different strategies implemented across Spanish autonomous communities (ACs) during the current epidemic season. Methods....
| Autores: | , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repositorio: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p6773 |
| Acceso en línea: | https://i3pt.portalinvestigacion.com/publicaciones/6773 https://www.scopus.com/inward/record.uri?eid=2-s2.0-105020774074&partnerID=40&md5=9abe12846bfc7e1d8caa887cfc0cf85a |
| Access Level: | acceso abierto |
| Palabra clave: | Acute bronchiolitis Emergency departments Respiratory syncytial virus Nirsevimab |
| Sumario: | Objectives. To evaluate the impact of respiratory syncytial virus (RSV) prophylaxis with nirsevimab during its 2nd year of administration and analyze the differences between the different strategies implemented across Spanish autonomous communities (ACs) during the current epidemic season. Methods. We conducted a retrospective analytical study with 15 pediatric emergency departments across 9 ACs. We included all infants younger than 6 months who were treated in November, December, and January during 5 epidemic seasons (2018-2019, 2019-2020, 2022-2023, 2023-2024, and 2024-2025). Results. Compared with the average of epidemic seasons prior to the introduction of nirsevimab, in 2024-2025 there was a 65.5% decrease in episodes of acute bronchiolitis (95% CI, 64.3-63.7; P < .001). Hospital admissions for bronchiolitis decreased by 74.7% (95% CI, 72.7-76.6; P < .001), and PICU admissions fell by 72.9% (95% CI, 68.1-77.2; P < .001). The reductions achieved in the 2024-2025 season were greater than those observed in the 2023-2024 season. The hospital from the AC that decided not to immunize infants born before the start of the epidemic had the worst outcomes. Among the ACs that applied the same strategy, worse outcomes were observed in the one that immunized out-of-season infants through selected hospitals rather than primary care centers. Conclusions. Nirsevimab prophylaxis in Spain during the 2024-2025 season provided even greater protection vs RSV infection in infants younger than 6 months. However, differences across ACs were observed, likely related to the specific immunization strategies implemented. |
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