Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)

Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational resear...

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Detalhes bibliográficos
Autores: Pizzio, Gaston A., Hirschi, Kendal D., Gaxiola, Roberto A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/248328
Acesso em linha:http://hdl.handle.net/10261/248328
Access Level:acceso abierto
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spelling Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)Pizzio, Gaston A. Hirschi, Kendal D.Gaxiola, Roberto A.Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H+-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H+-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity.GP was supported by Gobierno de España-Ministerio de Economía, Industria y Competitividad (fellowship Juan de la Cierva-Incorporación 2015). RG and KH were supported by the National Science Foundation (grant no. IOS-1557890). KH’s work is based in part on support by the United States Department of Agriculture, Agricultural Research Service under Agreement No. 58-3092-5-001.Peer reviewedFrontiers MediaNational Science Foundation (US)Department of Agriculture, Cooperative State Research, Education, and Extension Service (US)Ministerio de Economía, Industria y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/248328reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fpls.2017.01572Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2483282026-05-22T06:33:51Z
dc.title.none.fl_str_mv Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
title Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
spellingShingle Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
Pizzio, Gaston A.
title_short Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
title_full Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
title_fullStr Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
title_full_unstemmed Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
title_sort Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
dc.creator.none.fl_str_mv Pizzio, Gaston A.
Hirschi, Kendal D.
Gaxiola, Roberto A.
author Pizzio, Gaston A.
author_facet Pizzio, Gaston A.
Hirschi, Kendal D.
Gaxiola, Roberto A.
author_role author
author2 Hirschi, Kendal D.
Gaxiola, Roberto A.
author2_role author
author
dc.contributor.none.fl_str_mv National Science Foundation (US)
Department of Agriculture, Cooperative State Research, Education, and Extension Service (US)
Ministerio de Economía, Industria y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H+-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H+-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity.
publishDate 2017
dc.date.none.fl_str_mv 2017
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/248328
url http://hdl.handle.net/10261/248328
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3389/fpls.2017.01572
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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