Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients

A modified magnesium hydrogen breath test, using end expiratory breath sampling, is described to investigate achlorhydria. The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that i...

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Autores: Humbert Yagüe, Pere, López de Soria, P., Fernández Bañares, Fernando, Juncà i Piera, Jordi, Boix, J., Planas Vilà, Ramon, Quer Boniquet, Joan Carles, Domenech, E., Gassull, Miquel Àngel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1994
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/18662
Acceso en línea:https://hdl.handle.net/2445/18662
Access Level:acceso abierto
Palabra clave:Anèmia perniciosa
Pernicious anemia
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spelling Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patientsHumbert Yagüe, PereLópez de Soria, P.Fernández Bañares, FernandoJuncà i Piera, JordiBoix, J.Planas Vilà, RamonQuer Boniquet, Joan CarlesDomenech, E.Gassull, Miquel ÀngelAnèmia perniciosaPernicious anemiaA modified magnesium hydrogen breath test, using end expiratory breath sampling, is described to investigate achlorhydria. The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that is, patients with achlorhydria--and 22 with healed duodenal ulcer and normal chlorhydria were studied. Magnesium hydrogen breath test, serum pepsinogen I, serum gastrin, and standard gastric acid secretory tests were performed in all subjects. The mean (SEM) hydrogen peak value was lower in patients with pernicious anaemia than in the duodenal ulcer group (21.7 (1.9) v 71.3 (5.2) ppm; p = 0.00005). The hydrogen peak value had a 95.2% sensitivity and a 100% specificity to detect pentagastrin resistant achlorhydria. Mean serum pepsinogen I concentrations were also significantly lower in patients with pernicious anaemia than in the duodenal ulcer group (10.7 (2.7) v 123.6 (11.8) micrograms/l p = 0.00005). Sensitivity and specificity to detect pernicious anaemia were both 100% for pepsinogen I. It is concluded that this modified magnesium hydrogen breath test is a simple, noninvasive, cost effective, and accurate method to assess achlorhydria and may be useful in the diagnostic investigation of patients with suspected pernicious anaemia.BMJ Group1994info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/18662Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.35.9.1205Gut, 1994, vol. 35, núm. 9, p. 1205-1208http://dx.doi.org/10.1136/gut.35.9.1205(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1994info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/186622026-05-27T06:46:51Z
dc.title.none.fl_str_mv Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
title Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
spellingShingle Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
Humbert Yagüe, Pere
Anèmia perniciosa
Pernicious anemia
title_short Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
title_full Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
title_fullStr Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
title_full_unstemmed Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
title_sort Magnesium hydrogen breath test using end-expiratory sampling to assess achlorhydria in pernicious anaemia patients
dc.creator.none.fl_str_mv Humbert Yagüe, Pere
López de Soria, P.
Fernández Bañares, Fernando
Juncà i Piera, Jordi
Boix, J.
Planas Vilà, Ramon
Quer Boniquet, Joan Carles
Domenech, E.
Gassull, Miquel Àngel
author Humbert Yagüe, Pere
author_facet Humbert Yagüe, Pere
López de Soria, P.
Fernández Bañares, Fernando
Juncà i Piera, Jordi
Boix, J.
Planas Vilà, Ramon
Quer Boniquet, Joan Carles
Domenech, E.
Gassull, Miquel Àngel
author_role author
author2 López de Soria, P.
Fernández Bañares, Fernando
Juncà i Piera, Jordi
Boix, J.
Planas Vilà, Ramon
Quer Boniquet, Joan Carles
Domenech, E.
Gassull, Miquel Àngel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anèmia perniciosa
Pernicious anemia
topic Anèmia perniciosa
Pernicious anemia
description A modified magnesium hydrogen breath test, using end expiratory breath sampling, is described to investigate achlorhydria. The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that is, patients with achlorhydria--and 22 with healed duodenal ulcer and normal chlorhydria were studied. Magnesium hydrogen breath test, serum pepsinogen I, serum gastrin, and standard gastric acid secretory tests were performed in all subjects. The mean (SEM) hydrogen peak value was lower in patients with pernicious anaemia than in the duodenal ulcer group (21.7 (1.9) v 71.3 (5.2) ppm; p = 0.00005). The hydrogen peak value had a 95.2% sensitivity and a 100% specificity to detect pentagastrin resistant achlorhydria. Mean serum pepsinogen I concentrations were also significantly lower in patients with pernicious anaemia than in the duodenal ulcer group (10.7 (2.7) v 123.6 (11.8) micrograms/l p = 0.00005). Sensitivity and specificity to detect pernicious anaemia were both 100% for pepsinogen I. It is concluded that this modified magnesium hydrogen breath test is a simple, noninvasive, cost effective, and accurate method to assess achlorhydria and may be useful in the diagnostic investigation of patients with suspected pernicious anaemia.
publishDate 1994
dc.date.none.fl_str_mv 1994
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/18662
url https://hdl.handle.net/2445/18662
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.35.9.1205
Gut, 1994, vol. 35, núm. 9, p. 1205-1208
http://dx.doi.org/10.1136/gut.35.9.1205
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1994
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1994
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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