Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs

Introduction. Endometrial carcinoma (EC) is the commonest gynecological cancer affecting women in Western populations. To predict patient risk, the 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract stressed the importance of integrated histo-mol...

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Autores: Santoro, Angela, Bragantini, Emma, Castiglione, Francesca, Ganesan, Raji, Matias-Guiu, Xavier, 1958-, Frattini, Milo, Gallotta, Valerio, Garcia, Pablo, Pattni, Yatish, Tsiampali Laprell, Julia, Bisaro, Brigitte, Barbareschi, Mattia, Zannoni, Gian Franco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214211
Acceso en línea:https://hdl.handle.net/2445/214211
Access Level:acceso abierto
Palabra clave:Càncer d'endometri
Marcadors bioquímics
Endometrial cancer
Biochemical markers
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spelling Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labsSantoro, AngelaBragantini, EmmaCastiglione, FrancescaGanesan, RajiMatias-Guiu, Xavier, 1958-Frattini, MiloGallotta, ValerioGarcia, PabloPattni, YatishTsiampali Laprell, JuliaBisaro, BrigitteBarbareschi, MattiaZannoni, Gian FrancoCàncer d'endometriMarcadors bioquímicsEndometrial cancerBiochemical markersIntroduction. Endometrial carcinoma (EC) is the commonest gynecological cancer affecting women in Western populations. To predict patient risk, the 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract stressed the importance of integrated histo-molecular classification of the disease. This survey analysis poses attention on the most frequently used immunohistochemical and molecular markers adopted in daily categorization of ECs in European laboratories. Methods. We analyzed data collected through questionnaires administered to 40 Italian, 20 Spanish, 3 Swiss and 6 United Kingdom (UK) laboratories. We collected information regarding daily practice in EC evaluation, specifically concerning mismatch repair status (MMR) and microsatellite instability (MSI). Summary and descriptive statistical analyses were carried out to evaluate the current practice of each laboratory. Results. The results show that MMR status is mainly evaluated by using immunohistochemistry (IHC) on most EC samples. The most frequent approach for the analysis of MMR status is IHC of four proteins (PMS2, MSH6, MSH2, MLH1). MSI analysis by molecular methods is uncommon but useful as a supplemental tool in specific conditions. MLH1 promoter hypermethylation and BRAF V600 mutations analysis are performed in case of negative expression of MLH1/PMS2. Other markers (mainly p53 followed by POLE and PTEN) are investigated in particular in Spain and Switzerland in a consistent number of cases. Conclusion. Guidelines consultation and standardization of laboratory procedures are efficient means for EC prognostic risk stratification and improving the quality of care.Siapec Servizi Srl2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/214211Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.32074/1591-951X-926Pathologica, 2024, vol. 116, num. 1, p. 32-45https://doi.org/10.32074/1591-951X-926cc by-nc-nd (c) Santoro, Angela et al, 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2142112026-05-29T05:05:01Z
dc.title.none.fl_str_mv Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
title Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
spellingShingle Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
Santoro, Angela
Càncer d'endometri
Marcadors bioquímics
Endometrial cancer
Biochemical markers
title_short Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
title_full Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
title_fullStr Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
title_full_unstemmed Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
title_sort Biomarker characterization in endometrial cancer in Europe: first survey data analysis from 69 pathological academic and hospital labs
dc.creator.none.fl_str_mv Santoro, Angela
Bragantini, Emma
Castiglione, Francesca
Ganesan, Raji
Matias-Guiu, Xavier, 1958-
Frattini, Milo
Gallotta, Valerio
Garcia, Pablo
Pattni, Yatish
Tsiampali Laprell, Julia
Bisaro, Brigitte
Barbareschi, Mattia
Zannoni, Gian Franco
author Santoro, Angela
author_facet Santoro, Angela
Bragantini, Emma
Castiglione, Francesca
Ganesan, Raji
Matias-Guiu, Xavier, 1958-
Frattini, Milo
Gallotta, Valerio
Garcia, Pablo
Pattni, Yatish
Tsiampali Laprell, Julia
Bisaro, Brigitte
Barbareschi, Mattia
Zannoni, Gian Franco
author_role author
author2 Bragantini, Emma
Castiglione, Francesca
Ganesan, Raji
Matias-Guiu, Xavier, 1958-
Frattini, Milo
Gallotta, Valerio
Garcia, Pablo
Pattni, Yatish
Tsiampali Laprell, Julia
Bisaro, Brigitte
Barbareschi, Mattia
Zannoni, Gian Franco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'endometri
Marcadors bioquímics
Endometrial cancer
Biochemical markers
topic Càncer d'endometri
Marcadors bioquímics
Endometrial cancer
Biochemical markers
description Introduction. Endometrial carcinoma (EC) is the commonest gynecological cancer affecting women in Western populations. To predict patient risk, the 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract stressed the importance of integrated histo-molecular classification of the disease. This survey analysis poses attention on the most frequently used immunohistochemical and molecular markers adopted in daily categorization of ECs in European laboratories. Methods. We analyzed data collected through questionnaires administered to 40 Italian, 20 Spanish, 3 Swiss and 6 United Kingdom (UK) laboratories. We collected information regarding daily practice in EC evaluation, specifically concerning mismatch repair status (MMR) and microsatellite instability (MSI). Summary and descriptive statistical analyses were carried out to evaluate the current practice of each laboratory. Results. The results show that MMR status is mainly evaluated by using immunohistochemistry (IHC) on most EC samples. The most frequent approach for the analysis of MMR status is IHC of four proteins (PMS2, MSH6, MSH2, MLH1). MSI analysis by molecular methods is uncommon but useful as a supplemental tool in specific conditions. MLH1 promoter hypermethylation and BRAF V600 mutations analysis are performed in case of negative expression of MLH1/PMS2. Other markers (mainly p53 followed by POLE and PTEN) are investigated in particular in Spain and Switzerland in a consistent number of cases. Conclusion. Guidelines consultation and standardization of laboratory procedures are efficient means for EC prognostic risk stratification and improving the quality of care.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214211
url https://hdl.handle.net/2445/214211
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.32074/1591-951X-926
Pathologica, 2024, vol. 116, num. 1, p. 32-45
https://doi.org/10.32074/1591-951X-926
dc.rights.none.fl_str_mv cc by-nc-nd (c) Santoro, Angela et al, 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Santoro, Angela et al, 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Siapec Servizi Srl
publisher.none.fl_str_mv Siapec Servizi Srl
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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