Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions

The distribution of drugs and dietary phenolic compounds in the systemic circulation depends on, among other factors, unspecific/specific reversible binding to plasma proteins such as human serum albumin (HSA). Phenolic substances, present in plant-derived feeds, foods, beverages, herbal medicines,...

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Detalles Bibliográficos
Autores: López-Yerena, Anallely, Pérez Bosch, Maria, Vallverdú i Queralt, Anna, Escribano Ferrer, Elvira
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172712
Acceso en línea:https://hdl.handle.net/2445/172712
Access Level:acceso abierto
Palabra clave:Fenols
Polifenols
Farmacocinètica
Phenols
Polyphenols
Pharmacokinetics
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spelling Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug InteractionsLópez-Yerena, AnallelyPérez Bosch, MariaVallverdú i Queralt, AnnaEscribano Ferrer, ElviraFenolsPolifenolsFarmacocinèticaPhenolsPolyphenolsPharmacokineticsThe distribution of drugs and dietary phenolic compounds in the systemic circulation depends on, among other factors, unspecific/specific reversible binding to plasma proteins such as human serum albumin (HSA). Phenolic substances, present in plant-derived feeds, foods, beverages, herbal medicines, and dietary supplements, are of great interest due to their biological activity. Recently, considerable research has been directed at the formation of phenol-HSA complexes, focusing above all on structure-affinity relationships. The nucleophilicity and planarity of molecules can be altered by the number and position of hydroxyl groups on the aromatic ring and by hydrogenation. Binding affinities towards HSA may also differ between phenolic compounds in their native form and conjugates derived from phase II reactions. On the other hand, food-drug interactions may increase the concentration of free drugs in the blood, affecting their transport and/or disposition and in some cases provoking adverse or toxic effects. This is caused mainly by a decrease in drug binding affinities for HSA in the presence of flavonoids. Accordingly, to avoid the side effects arising from changes in plasma protein binding, the intake of flavonoid-rich food and beverages should be taken into consideration when treating certain pathologies.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/172712Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/pharmaceutics12111123Pharmaceutics, 2020, vol. 12, num. 11, p. 1123https://doi.org/10.3390/pharmaceutics12111123cc-by (c) López-Yerena, Anallely et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1727122026-05-27T06:46:51Z
dc.title.none.fl_str_mv Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
title Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
spellingShingle Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
López-Yerena, Anallely
Fenols
Polifenols
Farmacocinètica
Phenols
Polyphenols
Pharmacokinetics
title_short Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
title_full Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
title_fullStr Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
title_full_unstemmed Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
title_sort Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions
dc.creator.none.fl_str_mv López-Yerena, Anallely
Pérez Bosch, Maria
Vallverdú i Queralt, Anna
Escribano Ferrer, Elvira
author López-Yerena, Anallely
author_facet López-Yerena, Anallely
Pérez Bosch, Maria
Vallverdú i Queralt, Anna
Escribano Ferrer, Elvira
author_role author
author2 Pérez Bosch, Maria
Vallverdú i Queralt, Anna
Escribano Ferrer, Elvira
author2_role author
author
author
dc.subject.none.fl_str_mv Fenols
Polifenols
Farmacocinètica
Phenols
Polyphenols
Pharmacokinetics
topic Fenols
Polifenols
Farmacocinètica
Phenols
Polyphenols
Pharmacokinetics
description The distribution of drugs and dietary phenolic compounds in the systemic circulation depends on, among other factors, unspecific/specific reversible binding to plasma proteins such as human serum albumin (HSA). Phenolic substances, present in plant-derived feeds, foods, beverages, herbal medicines, and dietary supplements, are of great interest due to their biological activity. Recently, considerable research has been directed at the formation of phenol-HSA complexes, focusing above all on structure-affinity relationships. The nucleophilicity and planarity of molecules can be altered by the number and position of hydroxyl groups on the aromatic ring and by hydrogenation. Binding affinities towards HSA may also differ between phenolic compounds in their native form and conjugates derived from phase II reactions. On the other hand, food-drug interactions may increase the concentration of free drugs in the blood, affecting their transport and/or disposition and in some cases provoking adverse or toxic effects. This is caused mainly by a decrease in drug binding affinities for HSA in the presence of flavonoids. Accordingly, to avoid the side effects arising from changes in plasma protein binding, the intake of flavonoid-rich food and beverages should be taken into consideration when treating certain pathologies.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172712
url https://hdl.handle.net/2445/172712
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics12111123
Pharmaceutics, 2020, vol. 12, num. 11, p. 1123
https://doi.org/10.3390/pharmaceutics12111123
dc.rights.none.fl_str_mv cc-by (c) López-Yerena, Anallely et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) López-Yerena, Anallely et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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