HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study

Background: The burden of hepatitis C virus (HCV) infection among people who use drugs (PWUDs) is considerable. We aimed to screen for HCV infection using the fingerstick dried blood spot (DBS) test and to describe the cascade of hepatitis C care among PWUDs in Madrid, Spain. We also evaluated the p...

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Autores: Ryan, Pablo, Valencia, Jorge, Cuevas, Guillermo, Troya, Jesús, Ramon, Cristina, Rodríguez, Antonio, Torres-Macho, Juan, Muñoz-Gómez, María José, Canorea, Isabel, Vázquez-Morón, Sonia, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17500
Acceso en línea:http://hdl.handle.net/20.500.12105/17500
Access Level:acceso abierto
Palabra clave:Hepatitis B
Hepatitis C
Pharmaceutical Preparations
Hepacivirus
Hepatitis C Antibodies
Humans
Prospective Studies
Spain
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spelling HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective studyRyan, PabloValencia, JorgeCuevas, GuillermoTroya, JesúsRamon, CristinaRodríguez, AntonioTorres-Macho, JuanMuñoz-Gómez, María JoséCanorea, IsabelVázquez-Morón, SoniaResino, SalvadorHepatitis BHepatitis CPharmaceutical PreparationsHepacivirusHepatitis C AntibodiesHumansProspective StudiesSpainBackground: The burden of hepatitis C virus (HCV) infection among people who use drugs (PWUDs) is considerable. We aimed to screen for HCV infection using the fingerstick dried blood spot (DBS) test and to describe the cascade of hepatitis C care among PWUDs in Madrid, Spain. We also evaluated the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) in this population. Methods: We carried out a prospective study and collected samples and epidemiological data using a mobile unit. Viral infections were tested by immunoassay and RT-PCR assay. PWUDs with a positive result were contacted and referred to a specialized health center to confirm and treat the HCV infection. Results: We studied 529 PWUD samples; 49.7% were from persons who had previously used injection drugs (IDUs). Of these, 152 (28.7%) were positive for HCV antibodies, 122 (23.1%) for HCV RNA, 23 (4.3%) for HBsAg, and two (0.4%) for HDV antibodies (8.7% of those with hepatitis B). People who inject drugs (PWID) more frequently had positive HCV antibody titers (52% vs. 7.3%; p<0.001) and a positive HCV RNA test result (40.2% vs. 7.3%; p<0.001) than non-PWID. The time from sample collection to test results was 19 days. The next 104 individuals (85.2%) with active HCV infection were contacted to report their HCV test results. Of these, 63 (51.6%) had an appointment, 62 (50.8%) were evaluated in the hospital, and 56 (45.9%) started HCV therapy. Conclusion: HCV screening using fingerstick DBS was an excellent tool for determining HCV prevalence and other chronic hepatitis viruses (HBV and HDV) in PWUDs. However, linkage to care was limited, mainly with respect to the initiation of HCV therapy.ElsevierMerck, Sharp & DohmeInstituto de Salud Carlos III20242024-02-0620212021-06-0120212021-06-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17500reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/175002026-06-12T12:43:37Z
dc.title.none.fl_str_mv HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
title HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
spellingShingle HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
Ryan, Pablo
Hepatitis B
Hepatitis C
Pharmaceutical Preparations
Hepacivirus
Hepatitis C Antibodies
Humans
Prospective Studies
Spain
title_short HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
title_full HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
title_fullStr HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
title_full_unstemmed HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
title_sort HCV screening based on dried blood samples and linkage to care in people who use drugs: A prospective study
dc.creator.none.fl_str_mv Ryan, Pablo
Valencia, Jorge
Cuevas, Guillermo
Troya, Jesús
Ramon, Cristina
Rodríguez, Antonio
Torres-Macho, Juan
Muñoz-Gómez, María José
Canorea, Isabel
Vázquez-Morón, Sonia
Resino, Salvador
author Ryan, Pablo
author_facet Ryan, Pablo
Valencia, Jorge
Cuevas, Guillermo
Troya, Jesús
Ramon, Cristina
Rodríguez, Antonio
Torres-Macho, Juan
Muñoz-Gómez, María José
Canorea, Isabel
Vázquez-Morón, Sonia
Resino, Salvador
author_role author
author2 Valencia, Jorge
Cuevas, Guillermo
Troya, Jesús
Ramon, Cristina
Rodríguez, Antonio
Torres-Macho, Juan
Muñoz-Gómez, María José
Canorea, Isabel
Vázquez-Morón, Sonia
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Merck, Sharp & Dohme
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Hepatitis B
Hepatitis C
Pharmaceutical Preparations
Hepacivirus
Hepatitis C Antibodies
Humans
Prospective Studies
Spain
topic Hepatitis B
Hepatitis C
Pharmaceutical Preparations
Hepacivirus
Hepatitis C Antibodies
Humans
Prospective Studies
Spain
description Background: The burden of hepatitis C virus (HCV) infection among people who use drugs (PWUDs) is considerable. We aimed to screen for HCV infection using the fingerstick dried blood spot (DBS) test and to describe the cascade of hepatitis C care among PWUDs in Madrid, Spain. We also evaluated the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) in this population. Methods: We carried out a prospective study and collected samples and epidemiological data using a mobile unit. Viral infections were tested by immunoassay and RT-PCR assay. PWUDs with a positive result were contacted and referred to a specialized health center to confirm and treat the HCV infection. Results: We studied 529 PWUD samples; 49.7% were from persons who had previously used injection drugs (IDUs). Of these, 152 (28.7%) were positive for HCV antibodies, 122 (23.1%) for HCV RNA, 23 (4.3%) for HBsAg, and two (0.4%) for HDV antibodies (8.7% of those with hepatitis B). People who inject drugs (PWID) more frequently had positive HCV antibody titers (52% vs. 7.3%; p<0.001) and a positive HCV RNA test result (40.2% vs. 7.3%; p<0.001) than non-PWID. The time from sample collection to test results was 19 days. The next 104 individuals (85.2%) with active HCV infection were contacted to report their HCV test results. Of these, 63 (51.6%) had an appointment, 62 (50.8%) were evaluated in the hospital, and 56 (45.9%) started HCV therapy. Conclusion: HCV screening using fingerstick DBS was an excellent tool for determining HCV prevalence and other chronic hepatitis viruses (HBV and HDV) in PWUDs. However, linkage to care was limited, mainly with respect to the initiation of HCV therapy.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-06-01
2021
2021-06-01
2024
2024-02-06
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17500
url http://hdl.handle.net/20.500.12105/17500
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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