In-utero and childhood chemical exposome in six European mother-child cohorts

Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their chi...

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Autores: Haug, Line Småstuen, Casas Sanahuja, Maribel, Maitre, Léa, Basagaña Flores, Xavier, De Bont, Jeroen, 1989-, González, Juan Ramón, Sunyer Deu, Jordi, Urquiza, José M., Vrijheid, Martine, Thomsen, Cathrine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/43302
Acceso en línea:http://hdl.handle.net/10230/43302
http://dx.doi.org/10.1016/j.envint.2018.09.056
Access Level:acceso abierto
Palabra clave:Children
Exposome
Exposure
Mother-child pairs
Pregnant women
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oai_identifier_str oai:recercat.cat:10230/43302
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv In-utero and childhood chemical exposome in six European mother-child cohorts
title In-utero and childhood chemical exposome in six European mother-child cohorts
spellingShingle In-utero and childhood chemical exposome in six European mother-child cohorts
Haug, Line Småstuen
Children
Exposome
Exposure
Mother-child pairs
Pregnant women
title_short In-utero and childhood chemical exposome in six European mother-child cohorts
title_full In-utero and childhood chemical exposome in six European mother-child cohorts
title_fullStr In-utero and childhood chemical exposome in six European mother-child cohorts
title_full_unstemmed In-utero and childhood chemical exposome in six European mother-child cohorts
title_sort In-utero and childhood chemical exposome in six European mother-child cohorts
dc.creator.none.fl_str_mv Haug, Line Småstuen
Casas Sanahuja, Maribel
Maitre, Léa
Basagaña Flores, Xavier
De Bont, Jeroen, 1989-
González, Juan Ramón
Sunyer Deu, Jordi
Urquiza, José M.
Vrijheid, Martine
Thomsen, Cathrine
author Haug, Line Småstuen
author_facet Haug, Line Småstuen
Casas Sanahuja, Maribel
Maitre, Léa
Basagaña Flores, Xavier
De Bont, Jeroen, 1989-
González, Juan Ramón
Sunyer Deu, Jordi
Urquiza, José M.
Vrijheid, Martine
Thomsen, Cathrine
author_role author
author2 Casas Sanahuja, Maribel
Maitre, Léa
Basagaña Flores, Xavier
De Bont, Jeroen, 1989-
González, Juan Ramón
Sunyer Deu, Jordi
Urquiza, José M.
Vrijheid, Martine
Thomsen, Cathrine
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Children
Exposome
Exposure
Mother-child pairs
Pregnant women
topic Children
Exposome
Exposure
Mother-child pairs
Pregnant women
description Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. Methods: We relied on the Early-Life Exposome project, HELIX, a collaborative project across six established population-based birth cohort studies in Europe. In 1301 subjects, biomarkers of exposure to 45 contaminants (i.e. organochlorine compounds, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances, toxic and essential elements, phthalate metabolites, environmental phenols, organophosphate pesticide metabolites and cotinine) were measured in biological samples from children (6-12 years) and their mothers during pregnancy, using highly sensitive biomonitoring methods. Results: Most of the exposure biomarkers had high detection frequencies in mothers (35 out of 45 biomarkers with >90% detected) and children (33 out of 45 biomarkers with >90% detected). Concentrations were significantly different between cohorts for all compounds, and were generally higher in maternal compared to children samples. For most of the persistent compounds the correlations between maternal and child concentrations were moderate to high (Spearman Rho > 0.35), while for most non-persistent compounds correlations were considerably lower (Spearman Rho < 0.15). For mercury, PFOS and PFOA a considerable proportion of the samples of both mothers and their children exceeded the HBM I value established by The Human Biomonitoring Commission of the German Federal Environment Agency. Discussion: Although not based on a representative sample, our study suggests that children across Europe are exposed to a wide range of environmental contaminants in fetal life and childhood including many with potential adverse effects. For values exceeding the HBM I value identification of specific sources of exposure and reducing exposure in an adequate way is recommended. Considerable variability in this "chemical exposome" was seen between cohorts, showing that place of residence is a strong determinant of one's personal exposome. This extensive dataset comprising >100,000 concentrations of environmental contaminants in mother-child pairs forms a unique possibility for conducting epidemiological studies using an exposome approach.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43302
http://dx.doi.org/10.1016/j.envint.2018.09.056
url http://hdl.handle.net/10230/43302
http://dx.doi.org/10.1016/j.envint.2018.09.056
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environment International. 2018;121(Pt 1):751-63
info:eu-repo/grantAgreement/EC/FP7/308333
info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
info:eu-repo/grantAgreement/EC/FP7/211250
info:eu-repo/grantAgreement/EC/FP7/226285
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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spelling In-utero and childhood chemical exposome in six European mother-child cohortsHaug, Line SmåstuenCasas Sanahuja, MaribelMaitre, LéaBasagaña Flores, XavierDe Bont, Jeroen, 1989-González, Juan RamónSunyer Deu, JordiUrquiza, José M.Vrijheid, MartineThomsen, CathrineChildrenExposomeExposureMother-child pairsPregnant womenBackground: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. Methods: We relied on the Early-Life Exposome project, HELIX, a collaborative project across six established population-based birth cohort studies in Europe. In 1301 subjects, biomarkers of exposure to 45 contaminants (i.e. organochlorine compounds, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances, toxic and essential elements, phthalate metabolites, environmental phenols, organophosphate pesticide metabolites and cotinine) were measured in biological samples from children (6-12 years) and their mothers during pregnancy, using highly sensitive biomonitoring methods. Results: Most of the exposure biomarkers had high detection frequencies in mothers (35 out of 45 biomarkers with >90% detected) and children (33 out of 45 biomarkers with >90% detected). Concentrations were significantly different between cohorts for all compounds, and were generally higher in maternal compared to children samples. For most of the persistent compounds the correlations between maternal and child concentrations were moderate to high (Spearman Rho > 0.35), while for most non-persistent compounds correlations were considerably lower (Spearman Rho < 0.15). For mercury, PFOS and PFOA a considerable proportion of the samples of both mothers and their children exceeded the HBM I value established by The Human Biomonitoring Commission of the German Federal Environment Agency. Discussion: Although not based on a representative sample, our study suggests that children across Europe are exposed to a wide range of environmental contaminants in fetal life and childhood including many with potential adverse effects. For values exceeding the HBM I value identification of specific sources of exposure and reducing exposure in an adequate way is recommended. Considerable variability in this "chemical exposome" was seen between cohorts, showing that place of residence is a strong determinant of one's personal exposome. This extensive dataset comprising >100,000 concentrations of environmental contaminants in mother-child pairs forms a unique possibility for conducting epidemiological studies using an exposome approach.The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333 – the HELIX project. Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 31V-77). Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Rosie McEachan and John Wright were supported by the NIHR CLAHRC Yorkshire and Humber (IS-CLA-0113-10020). www.clahrc-yh.nihr.ac.uk. The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NINDS (grant no.1 UO1 NS 047537-01 and grant no.2 UO1 NS 047537-06A1). The REAH cohort was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15).Elsevier202020202018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43302http://dx.doi.org/10.1016/j.envint.2018.09.056reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironment International. 2018;121(Pt 1):751-63info:eu-repo/grantAgreement/EC/FP7/308333info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991info:eu-repo/grantAgreement/EC/FP7/211250info:eu-repo/grantAgreement/EC/FP7/226285© 2018 Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/433022026-05-29T05:05:01Z
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