Photothermic Release of Curcumin for Antimicrobial Photodynamic Therapy
[EN] Drug delivery systems (DDS) are promising tools to enhance antimicrobial Photodynamic Therapy (aPDT) by improving the targeted delivery and controlled release of photosensitizers. In this study, we introduce a light-responsive DDS based on curcumin-loaded mesoporous silica nanoparticles featuri...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:riunet______::bbb6f4266ce07c4a3cecb6a2b2dba362 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/234150 |
| Access Level: | acceso abierto |
| Palabra clave: | Curcumin Drug delivery systems (DDS) Antimicrobial Photodynamic Therapy (aPDT) |
| Sumario: | [EN] Drug delivery systems (DDS) are promising tools to enhance antimicrobial Photodynamic Therapy (aPDT) by improving the targeted delivery and controlled release of photosensitizers. In this study, we introduce a light-responsive DDS based on curcumin-loaded mesoporous silica nanoparticles featuring a gold nanostar core and paraffin capping, designed specifically for near-infrared (NIR)-triggered photothermal release. This multicomponent nanoplatform uniquely combines photothermal activation with light-controlled drug delivery for antimicrobial applications. The synthesized nanoparticles exhibited a mean diameter below 500 nm, a polydispersity index of 0.154, and a surface charge of ¿21.9 mV. Upon NIR irradiation at 1200 J/ cm2 , curcumin release was approximately 90%. In planktonic bacterial cultures, aPDT mediated by this system led to reductions of 3.16 log10 and 2.18 log10 in colony-forming units (CFUs) for Staphylococcus aureus and Pseudomonas aeruginosa, respectively. For bacterial biofilms, a higher curcumin concentration (1000 ¿g/mL) resulted in CFU reductions of 2.16 log10 and 1.77 log10 for S. aureus and P. aeruginosa, respectively. This study demonstrated a NIR-activated nanocarrier for the controlled release of curcumin and effective inactivation of both planktonic and biofilm-associated bacteria offering a new approach to improve the precision and efficacy of aPDT. |
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