The role of COMT, DAT and DRD2 polymorphisms on brain mechanisms of involuntary attention and cognitive control
[eng] Our genetic background plays a role in the way we face environmental changes and adapt our behavior adequately to the requirements of everyday life. The present research focuses on the role of three genes related to dopamine (DA) transmission on relevant cognitive processes, such as shifting a...
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| Tipo de documento: | tese |
| Estado: | Versão publicada |
| Data de publicação: | 2009 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/42799 |
| Acesso em linha: | https://hdl.handle.net/2445/42799 http://www.tdx.cat/TDX-0301110-175854 http://hdl.handle.net/10803/2722 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Genòmica Dopamina Cognició Genomics Dopamine Cognition |
| Resumo: | [eng] Our genetic background plays a role in the way we face environmental changes and adapt our behavior adequately to the requirements of everyday life. The present research focuses on the role of three genes related to dopamine (DA) transmission on relevant cognitive processes, such as shifting attention when required by the environmental demands or processing of unexpected but potentially relevant events. Prefrontal cortex (PFC) and striatum dopamine activity seem to play different roles in attentional processing and interact to regulate stability and flexible update of context information. Therefore, we studied the action of genes regulating PFC dopamine action (i.e., Catechol-O-Methyltransferase; COMT), reuptake of dopamine diffused on extrasynaptic striatal space (i.e., Dopamine Transporter; DAT) and the concentration of D2-type dopamine receptors (i.e., dopamine D2 receptors; DRD2). The results of these studies provide evidence for a relevant role of COMT, DAT1 and DRD2 genes in cognitive processes, which helps to understand cognitive disruption associated to dopamine dysregulation in psychiatric disorders. |
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