Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation

We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF).

Detalhes bibliográficos
Autores: Socuéllamos, Paula G., Macías, Álvaro, Benito-Bueno, Ángela de, Cruz, Francisco M., Redondo-Moya, María, Coronado, María José, Ramil, Elvira, Rosado, Silvia, Rios-Rosado, Elsa Carolina, Valencia-Avezuela, María, Andrés-Delgado, Laura, Blázquez, José Antonio, Forteza-Gil, Alberto, Gutiérrez-Rodríguez, Marta, Jalife, José, Valenzuela, Carmen
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2026
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::1acf95ca7c0fbc3429837ed2d7fcc60e
Acesso em linha:http://hdl.handle.net/10261/430663
Access Level:Acceso aberto
Palavra-chave:Atrial fibrillation
Lgi proteins
K(V)1.5 channelosome
I (Kur)
Descrição
Resumo:We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF).

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