Pharmacogenetics of ugt genes in North African populations

Cytochrome P450 (CYP450), sulfotransferase (SULT), and glucuronidase (UGT) enzymes play roles in the phase I and phase II metabolism of most clinically prescribed drugs. As polymorphisms in these genes may alter enzyme activities, most prescribed drugs will differ in their efficacy and side effects....

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Autores: Gaibar, M., Novillo, A., Romero-Lorca, A., Esteban i Torné, Maria Esther, Fernández-Santander, A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/133582
Acceso en línea:https://hdl.handle.net/2445/133582
Access Level:acceso abierto
Palabra clave:Enzims
Àfrica del Nord
Farmacogenètica
Enzymes
North Africa
Pharmacogenetics
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spelling Pharmacogenetics of ugt genes in North African populationsGaibar, M.Novillo, A.Romero-Lorca, A.Esteban i Torné, Maria EstherFernández-Santander, A.EnzimsÀfrica del NordFarmacogenèticaEnzymesNorth AfricaPharmacogeneticsCytochrome P450 (CYP450), sulfotransferase (SULT), and glucuronidase (UGT) enzymes play roles in the phase I and phase II metabolism of most clinically prescribed drugs. As polymorphisms in these genes may alter enzyme activities, most prescribed drugs will differ in their efficacy and side effects. In prior work, we showed that besides polymorphisms in CYP450, those in SULT and UGT also give rise to different serum levels of some drug metabolites than detected in wild-type carriers of the genes [1]. [...]Springer Nature2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/133582Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41397-018-0034-4The Pharmacogenomics Journal, 2018, vol. 18, p. 609-612https://doi.org/10.1038/s41397-018-0034-4cc by (c) Gaibar, M. et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1335822026-05-27T06:46:51Z
dc.title.none.fl_str_mv Pharmacogenetics of ugt genes in North African populations
title Pharmacogenetics of ugt genes in North African populations
spellingShingle Pharmacogenetics of ugt genes in North African populations
Gaibar, M.
Enzims
Àfrica del Nord
Farmacogenètica
Enzymes
North Africa
Pharmacogenetics
title_short Pharmacogenetics of ugt genes in North African populations
title_full Pharmacogenetics of ugt genes in North African populations
title_fullStr Pharmacogenetics of ugt genes in North African populations
title_full_unstemmed Pharmacogenetics of ugt genes in North African populations
title_sort Pharmacogenetics of ugt genes in North African populations
dc.creator.none.fl_str_mv Gaibar, M.
Novillo, A.
Romero-Lorca, A.
Esteban i Torné, Maria Esther
Fernández-Santander, A.
author Gaibar, M.
author_facet Gaibar, M.
Novillo, A.
Romero-Lorca, A.
Esteban i Torné, Maria Esther
Fernández-Santander, A.
author_role author
author2 Novillo, A.
Romero-Lorca, A.
Esteban i Torné, Maria Esther
Fernández-Santander, A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Enzims
Àfrica del Nord
Farmacogenètica
Enzymes
North Africa
Pharmacogenetics
topic Enzims
Àfrica del Nord
Farmacogenètica
Enzymes
North Africa
Pharmacogenetics
description Cytochrome P450 (CYP450), sulfotransferase (SULT), and glucuronidase (UGT) enzymes play roles in the phase I and phase II metabolism of most clinically prescribed drugs. As polymorphisms in these genes may alter enzyme activities, most prescribed drugs will differ in their efficacy and side effects. In prior work, we showed that besides polymorphisms in CYP450, those in SULT and UGT also give rise to different serum levels of some drug metabolites than detected in wild-type carriers of the genes [1]. [...]
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/133582
url https://hdl.handle.net/2445/133582
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41397-018-0034-4
The Pharmacogenomics Journal, 2018, vol. 18, p. 609-612
https://doi.org/10.1038/s41397-018-0034-4
dc.rights.none.fl_str_mv cc by (c) Gaibar, M. et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Gaibar, M. et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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