Human gut microbiota composition associated with international travels
Objective: The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food. Methods: Two pro...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repositorio: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p5019 |
| Acceso en línea: | https://i3pt.portalinvestigacion.com/publicaciones/5019 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85200513432&doi=10.1016%2fj.tmaid.2024.102747&partnerID=40&md5=dfa667343e1410eb13a2f00f52bf3f46 |
| Access Level: | acceso abierto |
| Palabra clave: | Adult Bacteria Feces Female Gastrointestinal Microbiome Humans Longitudinal Studies Male Middle Aged Phylogeny Prospective Studies RNA, Ribosomal, 16S Travel ribosome RNA RNA 16S Adonis adult antibiotic resistance Article Bacteroides bioinformatics cohort analysis comparative study controlled study disease association DNA extraction Escherichia Faecalibacterium female gene sequence hierarchical clustering human information processing intestine flora longitudinal study major clinical study male microbial diversity Parabacteroides prospective study rectal swab Shannon index Shigella travel bacterium classification feces genetics isolation and purification microbiology middle aged phylogeny |
| Sumario: | Objective: The objective of this study was to evaluate whether long stays in non-European countries influence the composition, diversity, and dynamics of gut microbiota, considering the potential impact of travelling, close contact with new people, and consumption of water and food. Methods: Two prospective cohorts were analyzed: (i) A longitudinal cohort comprising long-term travellers who provided fecal samples before and after their travels. (ii) A cohort consisting of long-term travellers and recently arrived migrants from non-European countries, which was compared with non-traveller controls. Each participant self-collected fecal samples and provided demographic and epidemiological data. Microbiota was characterized through 16 S rRNA gene sequencing. Results: The longitudinal cohort comprised 17 subjects. A trend toward higher bacterial diversity was observed after travelling (Shannon index 3.12vs3.26). vs 3.26). When comparing 84 travellers/migrants with 97 non-travellers, a confirmed association of higher diversity levels with travelling was observed (Phylogenetic diversity: 22.1vs20.9). vs 20.9). Specific genera enriched in travellers' gut microbiota were identified, including Escherichia/Shigella, Bacteroides, and Parabacteroides. . The analysis revealed three major clusters with profound differences in their bacterial composition, which exhibited differential distribution between travellers and non-travellers (Adonis P < 0.001; R2 = 30.6 %). Two clusters were more frequently observed in travellers: The first cluster, characterized by dominance of Escherichia/Shigella, exhibited the lowest levels of richness and diversity. The second cluster, dominated by Faecalibacterium and Bacteroides, , displayed the highest richness and diversity patterns. Conclusion: These findings highlight the diverse impact of international travel on gut microbiota composition and underscore the importance of considering microbiota resilience and diversity in understanding the health implications. |
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