Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin

Recently, modifications of Aβ levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement. To detect structural and functional brain ch...

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Autores: Cuberas-Borrós, Gemma|||0000-0001-5276-8212, Roca Bielsa, María Isabel, Boada, Mercè|||0000-0003-2617-3009, Tárraga, Lluís|||0000-0002-8423-946X, Hernández, Isabel|||0000-0001-8119-393X, Buendía, Mar, Rubio Álvarez, Lourdes, Torres, Gustavo, Bittini, Ángel, Guzmán-de-Villoria, Juan A., Pujadas, Francesc|||0000-0003-3569-2601, Torres, Mireia, Núñez, Laura, Castell-Conesa, Joan|||0000-0002-6449-9731, Páez, Antonio
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186383
Acesso em linha:https://ddd.uab.cat/record/186383
https://dx.doi.org/urn:doi:10.3233/JAD-170693
Access Level:acceso abierto
Palavra-chave:Albumin
Alzheimer's disease
Magnetic resonance imaging
Plasma exchange
Single-photon emission computed tomography
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spelling Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human AlbuminCuberas-Borrós, Gemma|||0000-0001-5276-8212Roca Bielsa, María IsabelBoada, Mercè|||0000-0003-2617-3009Tárraga, Lluís|||0000-0002-8423-946XHernández, Isabel|||0000-0001-8119-393XBuendía, MarRubio Álvarez, LourdesTorres, GustavoBittini, ÁngelGuzmán-de-Villoria, Juan A.Pujadas, Francesc|||0000-0003-3569-2601Torres, MireiaNúñez, LauraCastell-Conesa, Joan|||0000-0002-6449-9731Páez, AntonioAlbuminAlzheimer's diseaseMagnetic resonance imagingPlasma exchangeSingle-photon emission computed tomographyRecently, modifications of Aβ levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement. To detect structural and functional brain changes in PE-treated AD patients as part of a Phase II clinical trial. Patients received between 3 and 18 PE with albumin (Albutein ® 5%, Grifols) or sham-PE (controls) for 21 weeks (divided in one intensive and two maintenance periods) followed by 6-month follow-up. Brain perfusion assessed by SPECT scans using an automated software (NeuroGam ®) and brain structural changes assessed by MRI were performed at weeks 0 (baseline), 21, and 44 (with additional SPECT at weeks 9 and 33). Statistical parametric mapping (voxel-based analysis, SPM) and Z-scores calculations were applied to investigate changes to baseline. 42 patients were recruited (39 evaluable; 37 analyzed: 18 PE-treated; 19 controls). There was a trend toward decreasing hippocampi and total intracranial volume for both patient groups during the study (p < 0.05). After six months, PE-treated patients had less cerebral perfusion loss than controls in frontal, temporal, and parietal areas, and perfusion stabilization in Brodmann area BA38-R during the PE-treatment period (p < 0.05). SPM analysis showed stabilization or absence of progression of perfusion loss in PE-treated patients until week 21, not observed in controls. Mild-moderate AD patients showed decreased brain volume and impairment of brain perfusion as expected for the progression of the disease. PE-treatment with albumin replacement favored the stabilization of perfusion.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186383https://dx.doi.org/urn:doi:10.3233/JAD-170693reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1863832026-06-06T12:50:31Z
dc.title.none.fl_str_mv Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
title Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
spellingShingle Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
Cuberas-Borrós, Gemma|||0000-0001-5276-8212
Albumin
Alzheimer's disease
Magnetic resonance imaging
Plasma exchange
Single-photon emission computed tomography
title_short Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
title_full Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
title_fullStr Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
title_full_unstemmed Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
title_sort Longitudinal Neuroimaging Analysis in Mild-Moderate Alzheimer's Disease Patients Treated with Plasma Exchange with 5% Human Albumin
dc.creator.none.fl_str_mv Cuberas-Borrós, Gemma|||0000-0001-5276-8212
Roca Bielsa, María Isabel
Boada, Mercè|||0000-0003-2617-3009
Tárraga, Lluís|||0000-0002-8423-946X
Hernández, Isabel|||0000-0001-8119-393X
Buendía, Mar
Rubio Álvarez, Lourdes
Torres, Gustavo
Bittini, Ángel
Guzmán-de-Villoria, Juan A.
Pujadas, Francesc|||0000-0003-3569-2601
Torres, Mireia
Núñez, Laura
Castell-Conesa, Joan|||0000-0002-6449-9731
Páez, Antonio
author Cuberas-Borrós, Gemma|||0000-0001-5276-8212
author_facet Cuberas-Borrós, Gemma|||0000-0001-5276-8212
Roca Bielsa, María Isabel
Boada, Mercè|||0000-0003-2617-3009
Tárraga, Lluís|||0000-0002-8423-946X
Hernández, Isabel|||0000-0001-8119-393X
Buendía, Mar
Rubio Álvarez, Lourdes
Torres, Gustavo
Bittini, Ángel
Guzmán-de-Villoria, Juan A.
Pujadas, Francesc|||0000-0003-3569-2601
Torres, Mireia
Núñez, Laura
Castell-Conesa, Joan|||0000-0002-6449-9731
Páez, Antonio
author_role author
author2 Roca Bielsa, María Isabel
Boada, Mercè|||0000-0003-2617-3009
Tárraga, Lluís|||0000-0002-8423-946X
Hernández, Isabel|||0000-0001-8119-393X
Buendía, Mar
Rubio Álvarez, Lourdes
Torres, Gustavo
Bittini, Ángel
Guzmán-de-Villoria, Juan A.
Pujadas, Francesc|||0000-0003-3569-2601
Torres, Mireia
Núñez, Laura
Castell-Conesa, Joan|||0000-0002-6449-9731
Páez, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Albumin
Alzheimer's disease
Magnetic resonance imaging
Plasma exchange
Single-photon emission computed tomography
topic Albumin
Alzheimer's disease
Magnetic resonance imaging
Plasma exchange
Single-photon emission computed tomography
description Recently, modifications of Aβ levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer's disease (AD) treated with plasma exchange (PE) with albumin replacement. To detect structural and functional brain changes in PE-treated AD patients as part of a Phase II clinical trial. Patients received between 3 and 18 PE with albumin (Albutein ® 5%, Grifols) or sham-PE (controls) for 21 weeks (divided in one intensive and two maintenance periods) followed by 6-month follow-up. Brain perfusion assessed by SPECT scans using an automated software (NeuroGam ®) and brain structural changes assessed by MRI were performed at weeks 0 (baseline), 21, and 44 (with additional SPECT at weeks 9 and 33). Statistical parametric mapping (voxel-based analysis, SPM) and Z-scores calculations were applied to investigate changes to baseline. 42 patients were recruited (39 evaluable; 37 analyzed: 18 PE-treated; 19 controls). There was a trend toward decreasing hippocampi and total intracranial volume for both patient groups during the study (p < 0.05). After six months, PE-treated patients had less cerebral perfusion loss than controls in frontal, temporal, and parietal areas, and perfusion stabilization in Brodmann area BA38-R during the PE-treatment period (p < 0.05). SPM analysis showed stabilization or absence of progression of perfusion loss in PE-treated patients until week 21, not observed in controls. Mild-moderate AD patients showed decreased brain volume and impairment of brain perfusion as expected for the progression of the disease. PE-treatment with albumin replacement favored the stabilization of perfusion.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186383
https://dx.doi.org/urn:doi:10.3233/JAD-170693
url https://ddd.uab.cat/record/186383
https://dx.doi.org/urn:doi:10.3233/JAD-170693
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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