Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study

There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. Asthma patients 5-17 years old with ≥1 year of follow-u...

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Autores: Engelkes, Marjolein, Baan, Esme J.|||0000-0002-0735-4296, de Ridder, Maria A. J., Svensson, Elisabeth, Prieto-Alhambra, Daniel|||0000-0002-3950-6346, Lapi, Francesco, Giaquinto, Carlo, Picelli, Gino, Boudiaf, Nada, Albers, Frank|||0000-0001-7039-4621, Evitt, Lee A., Cockle, Sarah, Bradford, Eric, Van Dyke, Melissa K.|||0000-0001-7246-2093, Suruki, Robert, Rijnbeek, Peter|||0000-0003-0621-1979, Sturkenboom, Miriam C. J. M., Janssens, Hettie M., Verhamme, Katia M. C.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:232703
Acceso en línea:https://ddd.uab.cat/record/232703
https://dx.doi.org/urn:doi:10.1111/pai.13237
Access Level:acceso abierto
Palabra clave:Asthma: epidemiology
Asthma: risk factors
Epidemiology: prevalence
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spelling Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort studyEngelkes, MarjoleinBaan, Esme J.|||0000-0002-0735-4296de Ridder, Maria A. J.Svensson, ElisabethPrieto-Alhambra, Daniel|||0000-0002-3950-6346Lapi, FrancescoGiaquinto, CarloPicelli, GinoBoudiaf, NadaAlbers, Frank|||0000-0001-7039-4621Evitt, Lee A.Cockle, SarahBradford, EricVan Dyke, Melissa K.|||0000-0001-7246-2093Suruki, RobertRijnbeek, Peter|||0000-0003-0621-1979Sturkenboom, Miriam C. J. M.Janssens, Hettie M.Verhamme, Katia M. C.Asthma: epidemiologyAsthma: risk factorsEpidemiology: prevalenceThere are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. Asthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008-2013. Asthma was defined as ≥1 asthma-specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high-dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses. The cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient-years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3-45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year. In a real-world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/232703https://dx.doi.org/urn:doi:10.1111/pai.13237reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2327032026-06-06T12:50:31Z
dc.title.none.fl_str_mv Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
title Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
spellingShingle Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
Engelkes, Marjolein
Asthma: epidemiology
Asthma: risk factors
Epidemiology: prevalence
title_short Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
title_full Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
title_fullStr Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
title_full_unstemmed Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
title_sort Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
dc.creator.none.fl_str_mv Engelkes, Marjolein
Baan, Esme J.|||0000-0002-0735-4296
de Ridder, Maria A. J.
Svensson, Elisabeth
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Lapi, Francesco
Giaquinto, Carlo
Picelli, Gino
Boudiaf, Nada
Albers, Frank|||0000-0001-7039-4621
Evitt, Lee A.
Cockle, Sarah
Bradford, Eric
Van Dyke, Melissa K.|||0000-0001-7246-2093
Suruki, Robert
Rijnbeek, Peter|||0000-0003-0621-1979
Sturkenboom, Miriam C. J. M.
Janssens, Hettie M.
Verhamme, Katia M. C.
author Engelkes, Marjolein
author_facet Engelkes, Marjolein
Baan, Esme J.|||0000-0002-0735-4296
de Ridder, Maria A. J.
Svensson, Elisabeth
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Lapi, Francesco
Giaquinto, Carlo
Picelli, Gino
Boudiaf, Nada
Albers, Frank|||0000-0001-7039-4621
Evitt, Lee A.
Cockle, Sarah
Bradford, Eric
Van Dyke, Melissa K.|||0000-0001-7246-2093
Suruki, Robert
Rijnbeek, Peter|||0000-0003-0621-1979
Sturkenboom, Miriam C. J. M.
Janssens, Hettie M.
Verhamme, Katia M. C.
author_role author
author2 Baan, Esme J.|||0000-0002-0735-4296
de Ridder, Maria A. J.
Svensson, Elisabeth
Prieto-Alhambra, Daniel|||0000-0002-3950-6346
Lapi, Francesco
Giaquinto, Carlo
Picelli, Gino
Boudiaf, Nada
Albers, Frank|||0000-0001-7039-4621
Evitt, Lee A.
Cockle, Sarah
Bradford, Eric
Van Dyke, Melissa K.|||0000-0001-7246-2093
Suruki, Robert
Rijnbeek, Peter|||0000-0003-0621-1979
Sturkenboom, Miriam C. J. M.
Janssens, Hettie M.
Verhamme, Katia M. C.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Asthma: epidemiology
Asthma: risk factors
Epidemiology: prevalence
topic Asthma: epidemiology
Asthma: risk factors
Epidemiology: prevalence
description There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. Asthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008-2013. Asthma was defined as ≥1 asthma-specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high-dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses. The cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient-years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3-45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year. In a real-world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/232703
https://dx.doi.org/urn:doi:10.1111/pai.13237
url https://ddd.uab.cat/record/232703
https://dx.doi.org/urn:doi:10.1111/pai.13237
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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