Risk factors in severe anaphylaxis: which matters the most, food or cofactors?
Background: The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients who experience anaphylactic shock. Methods: Using lipid transfer protein (LTP)...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/227790 |
| Acceso en línea: | https://hdl.handle.net/2445/227790 |
| Access Level: | acceso abierto |
| Palabra clave: | Anafilaxi Al·lèrgia alimentària Anaphylaxis Food allergy |
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Risk factors in severe anaphylaxis: which matters the most, food or cofactors?Casas Saucedo, RocioCruz, Cinthia de laAraujo Sánchez, GiovannaGelis, SòniaJimenez, T.Riggioni, S.San Bartolome, ClaraPascal i Capdevila, MarionaBartra Tomàs, JoanMuñoz-Cano, RosaAnafilaxiAl·lèrgia alimentàriaAnaphylaxisFood allergyBackground: The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients who experience anaphylactic shock. Methods: Using lipid transfer protein (LTP) allergy as a model, we compared the characteristics of patients who developed anaphylaxis and anaphylactic shock. We recorded demographics, pollen sensitization, foods ingested up to 2 hours before onset of the reaction, and the presence of cofactors. Culprit foods were identified through a compatible clinical history and positive allergology work-up (skin prick test and/or sIgE). Results: We evaluated 150 reactions in 55 patients with anaphylaxis (134 reactions) and 12 with anaphylactic shock (16 reactions). Patients in the anaphylaxis group experienced twice as many reactions (mean [SD], 2.4 [2.5] for anaphylaxis vs 1.3 [1.5] for anaphylactic shock; P<.02). No relationship was found between any food group and severity of the reaction. The most frequent food involved in both groups of patients was the combination of several plant-derived foods (plant food mix), followed by peach and nuts. Indeed, in the reactions caused by plant food mix, the presence of a cofactor was observed more often than in other food groups. On the other hand, cofactors were not present in peach- and nut-related reactions. Exercise was the most frequent cofactor in all groups. Conclusion: In our series, the severity of the reactions was not determined by the kind of food or presence of a cofactor. Anaphylactic shock seems to be an infrequent presentation that may be associated with other individual-related factors requiring further evaluation.Esmon Publicidad S.A.2026202620222026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/227790Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.18176/jiaci.0698Journal of Investigational Allergology and Clinical Immunology, 2022, vol. 32, num. 4, p. 282-290https://doi.org/10.18176/jiaci.0698(c) Esmon Publicidad S.A., 2022info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2277902026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| title |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| spellingShingle |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? Casas Saucedo, Rocio Anafilaxi Al·lèrgia alimentària Anaphylaxis Food allergy |
| title_short |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| title_full |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| title_fullStr |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| title_full_unstemmed |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| title_sort |
Risk factors in severe anaphylaxis: which matters the most, food or cofactors? |
| dc.creator.none.fl_str_mv |
Casas Saucedo, Rocio Cruz, Cinthia de la Araujo Sánchez, Giovanna Gelis, Sònia Jimenez, T. Riggioni, S. San Bartolome, Clara Pascal i Capdevila, Mariona Bartra Tomàs, Joan Muñoz-Cano, Rosa |
| author |
Casas Saucedo, Rocio |
| author_facet |
Casas Saucedo, Rocio Cruz, Cinthia de la Araujo Sánchez, Giovanna Gelis, Sònia Jimenez, T. Riggioni, S. San Bartolome, Clara Pascal i Capdevila, Mariona Bartra Tomàs, Joan Muñoz-Cano, Rosa |
| author_role |
author |
| author2 |
Cruz, Cinthia de la Araujo Sánchez, Giovanna Gelis, Sònia Jimenez, T. Riggioni, S. San Bartolome, Clara Pascal i Capdevila, Mariona Bartra Tomàs, Joan Muñoz-Cano, Rosa |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Anafilaxi Al·lèrgia alimentària Anaphylaxis Food allergy |
| topic |
Anafilaxi Al·lèrgia alimentària Anaphylaxis Food allergy |
| description |
Background: The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients who experience anaphylactic shock. Methods: Using lipid transfer protein (LTP) allergy as a model, we compared the characteristics of patients who developed anaphylaxis and anaphylactic shock. We recorded demographics, pollen sensitization, foods ingested up to 2 hours before onset of the reaction, and the presence of cofactors. Culprit foods were identified through a compatible clinical history and positive allergology work-up (skin prick test and/or sIgE). Results: We evaluated 150 reactions in 55 patients with anaphylaxis (134 reactions) and 12 with anaphylactic shock (16 reactions). Patients in the anaphylaxis group experienced twice as many reactions (mean [SD], 2.4 [2.5] for anaphylaxis vs 1.3 [1.5] for anaphylactic shock; P<.02). No relationship was found between any food group and severity of the reaction. The most frequent food involved in both groups of patients was the combination of several plant-derived foods (plant food mix), followed by peach and nuts. Indeed, in the reactions caused by plant food mix, the presence of a cofactor was observed more often than in other food groups. On the other hand, cofactors were not present in peach- and nut-related reactions. Exercise was the most frequent cofactor in all groups. Conclusion: In our series, the severity of the reactions was not determined by the kind of food or presence of a cofactor. Anaphylactic shock seems to be an infrequent presentation that may be associated with other individual-related factors requiring further evaluation. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/227790 |
| url |
https://hdl.handle.net/2445/227790 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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Reproducció del document publicat a: https://doi.org/10.18176/jiaci.0698 Journal of Investigational Allergology and Clinical Immunology, 2022, vol. 32, num. 4, p. 282-290 https://doi.org/10.18176/jiaci.0698 |
| dc.rights.none.fl_str_mv |
(c) Esmon Publicidad S.A., 2022 info:eu-repo/semantics/openAccess |
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(c) Esmon Publicidad S.A., 2022 |
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openAccess |
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9 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Esmon Publicidad S.A. |
| publisher.none.fl_str_mv |
Esmon Publicidad S.A. |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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