Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity
Obesity is an important public health problem worldwide and is a major risk factor for a number of chronic diseases such as type 2 diabetes, adverse cardiovascular events and metabolic syndrome related features. Different treatments have been applied to tackle body fat accumulation and its associate...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/37077 |
| Acceso en línea: | https://hdl.handle.net/10171/37077 |
| Access Level: | acceso abierto |
| Palabra clave: | Obesity Body weight loss Intermittent hypoxia Treatment |
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Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesityUrdampilleta, A. (Aritz)|||/items/2500b3e3-89d6-4409-b91a-93e9370ab9daGonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131ObesityBody weight lossIntermittent hypoxiaTreatmentObesity is an important public health problem worldwide and is a major risk factor for a number of chronic diseases such as type 2 diabetes, adverse cardiovascular events and metabolic syndrome related features. Different treatments have been applied to tackle body fat accumulation and its associated clinical manifestations. Often, relevant weight loss is achieved during the first six months under different dietary treatments. From this point, a plateau is reached, and a gradual recovery of the lost weight may occur. Therefore, new research approaches are being investigated to assure weight maintenance. Pioneering investigations have reported that oxygen variations in organic systems may produce changes in body composition. Possible applications of intermittent hypoxia to promote health and in various pathophysiological states have been reported. The hypoxic stimulus in addition to diet and exercise can be an interesting approach to lose weight, by inducing higher basal noradrenalin levels and other metabolic changes whose mechanisms are still unclear. Indeed, hypoxic situations increase the diameter of arterioles, produce peripheral vasodilatation and decrease arterial blood pressure. Furthermore, hypoxic training increases the activity of glycolytic enzymes, enhancing the number of mitochondria and glucose transporter GLUT-4 levels as well as improving insulin sensitivity. Moreover, hypoxia increases blood serotonin, decreases leptin levels while appetite is suppressed. These observations allow considering the hypothesis that intermittent hypoxia induces fat loss and may ameliorate cardiovascular health, which might be of interest for the treatment of obesity. This new strategy may be useful and practical for clinical applications in obese patients.Springer VerlagDadun. Depósito Académico Digital Universidad de Navarra20142014-11-2120122012-01-0120122012-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/37077reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/370772026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| title |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| spellingShingle |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity Urdampilleta, A. (Aritz)|||/items/2500b3e3-89d6-4409-b91a-93e9370ab9da Obesity Body weight loss Intermittent hypoxia Treatment |
| title_short |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| title_full |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| title_fullStr |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| title_full_unstemmed |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| title_sort |
Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity |
| dc.creator.none.fl_str_mv |
Urdampilleta, A. (Aritz)|||/items/2500b3e3-89d6-4409-b91a-93e9370ab9da Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author |
Urdampilleta, A. (Aritz)|||/items/2500b3e3-89d6-4409-b91a-93e9370ab9da |
| author_facet |
Urdampilleta, A. (Aritz)|||/items/2500b3e3-89d6-4409-b91a-93e9370ab9da Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author_role |
author |
| author2 |
Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Obesity Body weight loss Intermittent hypoxia Treatment |
| topic |
Obesity Body weight loss Intermittent hypoxia Treatment |
| description |
Obesity is an important public health problem worldwide and is a major risk factor for a number of chronic diseases such as type 2 diabetes, adverse cardiovascular events and metabolic syndrome related features. Different treatments have been applied to tackle body fat accumulation and its associated clinical manifestations. Often, relevant weight loss is achieved during the first six months under different dietary treatments. From this point, a plateau is reached, and a gradual recovery of the lost weight may occur. Therefore, new research approaches are being investigated to assure weight maintenance. Pioneering investigations have reported that oxygen variations in organic systems may produce changes in body composition. Possible applications of intermittent hypoxia to promote health and in various pathophysiological states have been reported. The hypoxic stimulus in addition to diet and exercise can be an interesting approach to lose weight, by inducing higher basal noradrenalin levels and other metabolic changes whose mechanisms are still unclear. Indeed, hypoxic situations increase the diameter of arterioles, produce peripheral vasodilatation and decrease arterial blood pressure. Furthermore, hypoxic training increases the activity of glycolytic enzymes, enhancing the number of mitochondria and glucose transporter GLUT-4 levels as well as improving insulin sensitivity. Moreover, hypoxia increases blood serotonin, decreases leptin levels while appetite is suppressed. These observations allow considering the hypothesis that intermittent hypoxia induces fat loss and may ameliorate cardiovascular health, which might be of interest for the treatment of obesity. This new strategy may be useful and practical for clinical applications in obese patients. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2012-01-01 2012 2012-01-01 2014 2014-11-21 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/37077 |
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https://hdl.handle.net/10171/37077 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Verlag |
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Springer Verlag |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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