Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain

Introduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and pro...

ver descrição completa

Detalhes bibliográficos
Autores: Frias-Gomez, Jon, Tovar, Eva, Vidal, August, Murgui, Luis, Ibáñez, Raquel, Peremiquel-Trillas, Paula, Paytubi, Sonia, Baixeras, Núria, Zanca, Alba, Ponce, Jordi, Pineda, Marta, Brunet, Joan, de Sanjosé, Silvia, Bosch, Francesc Xavier, Matias-Guiu, Xavier, Alemany, Laia, Costas, Laura
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/467692
Acesso em linha:https://doi.org/10.1002/cam4.4217
https://hdl.handle.net/10459.1/467692
Access Level:acceso abierto
Palavra-chave:Cervical cytology
Cervico-vaginal cytology
Endometrial cancer
Sensitivity
id ES_a3e6e09073dc8cf1bbb2afa20cbfc090
oai_identifier_str oai:recercat.cat:10459.1/467692
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in SpainFrias-Gomez, JonTovar, EvaVidal, AugustMurgui, LuisIbáñez, RaquelPeremiquel-Trillas, PaulaPaytubi, SoniaBaixeras, NúriaZanca, AlbaPonce, JordiPineda, MartaBrunet, Joande Sanjosé, SilviaBosch, Francesc XavierMatias-Guiu, XavierAlemany, LaiaCostas, LauraCervical cytologyCervico-vaginal cytologyEndometrial cancerSensitivityIntroduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and prognosis in a large population over a 30-year period in a large academic tertiary hospital in Spain. Methodology: We performed a search for women diagnosed with endometrial cancer from 1990 to 2020, who were surgically treated and had a previous cervical cytology result. Information Technologies Department databases from Bellvitge University Hospital and the Screenwide case-control study's database were used. Cervical cytology results were classified as abnormal when squamous lesions, glandular atypia or malignant cells were identified. Results: Overall, we evaluated 371 women with endometrial cancer and a documented cervical cytology performed within 3 years previous to surgical treatment. Overall, the sensitivity of cervical cytology for endometrial cancer detection was 25.6%. Several clinico-pathological characteristics, such as non-endometrioid histology and a higher stage, were correlated with higher sensitivity. Discussion: We observed a low sensitivity of cervical cytology to effectively diagnose endometrial cancer. However, recent technological advances using genomics and epigenomics may offer a promising perspective to detect endometrial cancer with high sensitivity in these cervical specimens.John Wiley & SonsScreenwide Team2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1002/cam4.4217https://hdl.handle.net/10459.1/467692reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/cam4.4217Cancer Medicine, 2021, vol. 10, núm. 19, p. 6762-6766cc-by (c)The Authors, 2021info:eu-repo/semantics/openAccessoai:recercat.cat:10459.1/4676922026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
spellingShingle Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
Frias-Gomez, Jon
Cervical cytology
Cervico-vaginal cytology
Endometrial cancer
Sensitivity
title_short Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_full Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_fullStr Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_full_unstemmed Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
title_sort Sensitivity of cervical cytology in endometrial cancer detection in a tertiary hospital in Spain
dc.creator.none.fl_str_mv Frias-Gomez, Jon
Tovar, Eva
Vidal, August
Murgui, Luis
Ibáñez, Raquel
Peremiquel-Trillas, Paula
Paytubi, Sonia
Baixeras, Núria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
de Sanjosé, Silvia
Bosch, Francesc Xavier
Matias-Guiu, Xavier
Alemany, Laia
Costas, Laura
author Frias-Gomez, Jon
author_facet Frias-Gomez, Jon
Tovar, Eva
Vidal, August
Murgui, Luis
Ibáñez, Raquel
Peremiquel-Trillas, Paula
Paytubi, Sonia
Baixeras, Núria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
de Sanjosé, Silvia
Bosch, Francesc Xavier
Matias-Guiu, Xavier
Alemany, Laia
Costas, Laura
author_role author
author2 Tovar, Eva
Vidal, August
Murgui, Luis
Ibáñez, Raquel
Peremiquel-Trillas, Paula
Paytubi, Sonia
Baixeras, Núria
Zanca, Alba
Ponce, Jordi
Pineda, Marta
Brunet, Joan
de Sanjosé, Silvia
Bosch, Francesc Xavier
Matias-Guiu, Xavier
Alemany, Laia
Costas, Laura
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Screenwide Team
dc.subject.none.fl_str_mv Cervical cytology
Cervico-vaginal cytology
Endometrial cancer
Sensitivity
topic Cervical cytology
Cervico-vaginal cytology
Endometrial cancer
Sensitivity
description Introduction: Cervical cytology is a well-stablished cervical cancer screening method. However, due to the anatomical continuity of the genital tract, it can also detect signs of endometrial disease. Our aim was to estimate the sensitivity of cervical cytology in endometrial cancer detection and prognosis in a large population over a 30-year period in a large academic tertiary hospital in Spain. Methodology: We performed a search for women diagnosed with endometrial cancer from 1990 to 2020, who were surgically treated and had a previous cervical cytology result. Information Technologies Department databases from Bellvitge University Hospital and the Screenwide case-control study's database were used. Cervical cytology results were classified as abnormal when squamous lesions, glandular atypia or malignant cells were identified. Results: Overall, we evaluated 371 women with endometrial cancer and a documented cervical cytology performed within 3 years previous to surgical treatment. Overall, the sensitivity of cervical cytology for endometrial cancer detection was 25.6%. Several clinico-pathological characteristics, such as non-endometrioid histology and a higher stage, were correlated with higher sensitivity. Discussion: We observed a low sensitivity of cervical cytology to effectively diagnose endometrial cancer. However, recent technological advances using genomics and epigenomics may offer a promising perspective to detect endometrial cancer with high sensitivity in these cervical specimens.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/cam4.4217
https://hdl.handle.net/10459.1/467692
url https://doi.org/10.1002/cam4.4217
https://hdl.handle.net/10459.1/467692
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/cam4.4217
Cancer Medicine, 2021, vol. 10, núm. 19, p. 6762-6766
dc.rights.none.fl_str_mv cc-by (c)The Authors, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c)The Authors, 2021
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415435822170112
score 15,811543

Registos relacionados