Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas

AIMS: The aim of this work is the study of the prognostic significance of the chromosomal aberrations described in a series of invasive ductal breast carcinomas. METHODS AND RESULTS: We analysed by comparative genomic hybridization a group of 70 formalin-fixed paraffin-embedded invasive ductal breas...

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Detalles Bibliográficos
Autores: Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551, Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251, Caballero, M.C. (M.C.)|||/items/40abd0f7-9523-436a-8168-7f6e8ec7e8c2, Valenti, C. (C.)|||/items/3bd99f0b-353e-41a9-9e0e-3223d36605bf, Martinez-Peñuela, J.M. (J.M.)|||/items/92cff34e-5fcc-4acc-a480-045258606ba5, Isola, J. (J.)|||/items/385d2d3c-05ff-469e-aea4-43803f27730c, Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086
Tipo de recurso: artículo
Fecha de publicación:2002
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/19583
Acceso en línea:https://hdl.handle.net/10171/19583
Access Level:acceso abierto
Palabra clave:CGH
Prognostic factors
Invasive ductal breast carcinomas
6q gains
16q losses
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spelling Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomasZudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251Caballero, M.C. (M.C.)|||/items/40abd0f7-9523-436a-8168-7f6e8ec7e8c2Valenti, C. (C.)|||/items/3bd99f0b-353e-41a9-9e0e-3223d36605bfMartinez-Peñuela, J.M. (J.M.)|||/items/92cff34e-5fcc-4acc-a480-045258606ba5Isola, J. (J.)|||/items/385d2d3c-05ff-469e-aea4-43803f27730cCalasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086CGHPrognostic factorsInvasive ductal breast carcinomas6q gains16q lossesAIMS: The aim of this work is the study of the prognostic significance of the chromosomal aberrations described in a series of invasive ductal breast carcinomas. METHODS AND RESULTS: We analysed by comparative genomic hybridization a group of 70 formalin-fixed paraffin-embedded invasive ductal breast carcinomas. Aberrations showed a frequency similar to previous studies using frozen tumours. Interestingly, we identified gains involving 6q16-q24 more frequently than in other series. We analysed the association among the chromosomal imbalances, 11 histopathological factors, relapse rate and overall survival of patients. Associations showed 16q losses as a potential marker of good prognosis, as they were more frequent in node-negative (P=0.025) and in oestrogen-positive tumours (P < 0.001). Furthermore, 100% of bcl-2+ tumours presented this aberration compared with 29.3% in bcl-2- (P=0.014). 1q, 11q, 17q and 20q gains were associated with poor prognosis: 95% of cases with 1q gains were bigger than 20 mm (P=0.041). Tumours with 1q and 11q gains showed a higher relapse rate (P=0.063; P=0.066). Within the good prognosis group of lymph node-negative patients, 17q and 20q gains identify a subgroup with increased relapse rate (P=0.039). CONCLUSIONS: Chromosomal imbalances, together with histopathological factors, may help to predict outcome in breast cancer patients.Blackwell PublishingDadun. Depósito Académico Digital Universidad de Navarra20112011-11-1020022002-01-0120022002-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/19583reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/195832026-06-21T12:47:57Z
dc.title.none.fl_str_mv Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
title Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
spellingShingle Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551
CGH
Prognostic factors
Invasive ductal breast carcinomas
6q gains
16q losses
title_short Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
title_full Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
title_fullStr Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
title_full_unstemmed Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
title_sort Genomic imbalances detected by comparative genomic hybridization are prognostic markers in invasive ductal breast carcinomas
dc.creator.none.fl_str_mv Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551
Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
Caballero, M.C. (M.C.)|||/items/40abd0f7-9523-436a-8168-7f6e8ec7e8c2
Valenti, C. (C.)|||/items/3bd99f0b-353e-41a9-9e0e-3223d36605bf
Martinez-Peñuela, J.M. (J.M.)|||/items/92cff34e-5fcc-4acc-a480-045258606ba5
Isola, J. (J.)|||/items/385d2d3c-05ff-469e-aea4-43803f27730c
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086
author Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551
author_facet Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551
Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
Caballero, M.C. (M.C.)|||/items/40abd0f7-9523-436a-8168-7f6e8ec7e8c2
Valenti, C. (C.)|||/items/3bd99f0b-353e-41a9-9e0e-3223d36605bf
Martinez-Peñuela, J.M. (J.M.)|||/items/92cff34e-5fcc-4acc-a480-045258606ba5
Isola, J. (J.)|||/items/385d2d3c-05ff-469e-aea4-43803f27730c
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086
author_role author
author2 Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
Caballero, M.C. (M.C.)|||/items/40abd0f7-9523-436a-8168-7f6e8ec7e8c2
Valenti, C. (C.)|||/items/3bd99f0b-353e-41a9-9e0e-3223d36605bf
Martinez-Peñuela, J.M. (J.M.)|||/items/92cff34e-5fcc-4acc-a480-045258606ba5
Isola, J. (J.)|||/items/385d2d3c-05ff-469e-aea4-43803f27730c
Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv CGH
Prognostic factors
Invasive ductal breast carcinomas
6q gains
16q losses
topic CGH
Prognostic factors
Invasive ductal breast carcinomas
6q gains
16q losses
description AIMS: The aim of this work is the study of the prognostic significance of the chromosomal aberrations described in a series of invasive ductal breast carcinomas. METHODS AND RESULTS: We analysed by comparative genomic hybridization a group of 70 formalin-fixed paraffin-embedded invasive ductal breast carcinomas. Aberrations showed a frequency similar to previous studies using frozen tumours. Interestingly, we identified gains involving 6q16-q24 more frequently than in other series. We analysed the association among the chromosomal imbalances, 11 histopathological factors, relapse rate and overall survival of patients. Associations showed 16q losses as a potential marker of good prognosis, as they were more frequent in node-negative (P=0.025) and in oestrogen-positive tumours (P < 0.001). Furthermore, 100% of bcl-2+ tumours presented this aberration compared with 29.3% in bcl-2- (P=0.014). 1q, 11q, 17q and 20q gains were associated with poor prognosis: 95% of cases with 1q gains were bigger than 20 mm (P=0.041). Tumours with 1q and 11q gains showed a higher relapse rate (P=0.063; P=0.066). Within the good prognosis group of lymph node-negative patients, 17q and 20q gains identify a subgroup with increased relapse rate (P=0.039). CONCLUSIONS: Chromosomal imbalances, together with histopathological factors, may help to predict outcome in breast cancer patients.
publishDate 2002
dc.date.none.fl_str_mv 2002
2002-01-01
2002
2002-01-01
2011
2011-11-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/19583
url https://hdl.handle.net/10171/19583
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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