Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program

Background/Objectives: Heart failure (HF) is a leading cause of hospitalization in older adults, with significant sex differences in presentation, treatment, and outcomes. Transitional care models may benefit women more, yet they often receive less follow-up. This study assessed whether the clinical...

Descripción completa

Detalles Bibliográficos
Autores: Conde Martel, Alicia, Méndez Bailón, Manuel, Montero Pérez-Barquero, Manuel, González Franco, Álvaro, Cerqueiro, José Manuel, Pérez Silvestre, José, Fernández Rodríguez, José María, Llàcer, Pau, Casado Cerrada, Jesús, Formiga Pérez, Francesc, Salamanca Bautista, Prado, Arévalo Lorido, José Carlos, Manzano Espinosa, Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223346
Acceso en línea:https://hdl.handle.net/2445/223346
http://hdl.handle.net/2445/223346
Access Level:acceso abierto
Palabra clave:Insuficiència cardíaca
Factors sexuals en les malalties
Heart failure
Sex factors in disease
id ES_a3d9569da76a0cb0a7ecebba3099d96b
oai_identifier_str oai:recercat.cat:2445/223346
network_acronym_str ES
network_name_str España
repository_id_str
spelling Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC programConde Martel, AliciaMéndez Bailón, ManuelMontero Pérez-Barquero, ManuelGonzález Franco, ÁlvaroCerqueiro, José ManuelPérez Silvestre, JoséFernández Rodríguez, José MaríaLlàcer, PauCasado Cerrada, JesúsFormiga Pérez, FrancescSalamanca Bautista, PradoArévalo Lorido, José CarlosManzano Espinosa, LuisInsuficiència cardíacaFactors sexuals en les malaltiesHeart failureSex factors in diseaseBackground/Objectives: Heart failure (HF) is a leading cause of hospitalization in older adults, with significant sex differences in presentation, treatment, and outcomes. Transitional care models may benefit women more, yet they often receive less follow-up. This study assessed whether the clinical impact of the UMIPIC multidisciplinary HF management program differs by sex. Methods: This prospective, multicenter, observational cohort study included HF patients enrolled in the UMIPIC program or followed through conventional care in the RICA registry. Outcomes (30-day and one-year mortality and readmissions) were compared between groups, stratified by sex. Multivariate Cox models adjusted for age, HF phenotype, comorbidities, and baseline therapy. Results: A total of 5644 HF patients were included, with 2034 (36%) managed in UMIPIC and 3610 (64%) receiving conventional care. Women represented 55% of UMIPIC patients and were older, with higher prevalence of hypertension, anemia, and HF with preserved ejection fraction (HFpEF) compared to conventional care. At 30 days, women in UMIPIC had lower all-cause mortality (4.0% vs. 8.0%), cardiovascular mortality (2.0% vs. 6.0%), and readmissions (9.0% vs. 18.0%; all p < 0.01); these benefits persisted at one year. In multivariate analysis, UMIPIC enrollment remained protective (HR: 0.79; 95% CI: 0.71-0.87; p < 0.001). In men, UMIPIC patients were older with more comorbidities and higher HFpEF prevalence. They also showed lower 30-day mortality (2.0% vs. 8.0%; p < 0.05) and readmissions (8.0% vs. 18.0%; p < 0.01), with benefits maintained at one year. UMIPIC enrollment remained independently associated with reduced one-year mortality in men (HR: 0.79; 95% CI: 0.71-0.88; p < 0.001). Conclusions: The UMIPIC multidisciplinary care model reduced one-year mortality and readmissions in both women and men with HF, supporting integrated care strategies to improve outcomes in this high-risk population.MDPI2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/223346http://hdl.handle.net/2445/223346Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm14165818Journal of Clinical Medicine, 2025, vol. 14, num. 16, 5818https://doi.org/10.3390/jcm14165818cc-by (c) Conde Martel, Alicia et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2233462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
title Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
spellingShingle Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
Conde Martel, Alicia
Insuficiència cardíaca
Factors sexuals en les malalties
Heart failure
Sex factors in disease
title_short Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
title_full Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
title_fullStr Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
title_full_unstemmed Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
title_sort Are there gender differences in the benefits of multidisciplinary care in patients with heart failure? Results from the UMIPIC program
dc.creator.none.fl_str_mv Conde Martel, Alicia
Méndez Bailón, Manuel
Montero Pérez-Barquero, Manuel
González Franco, Álvaro
Cerqueiro, José Manuel
Pérez Silvestre, José
Fernández Rodríguez, José María
Llàcer, Pau
Casado Cerrada, Jesús
Formiga Pérez, Francesc
Salamanca Bautista, Prado
Arévalo Lorido, José Carlos
Manzano Espinosa, Luis
author Conde Martel, Alicia
author_facet Conde Martel, Alicia
Méndez Bailón, Manuel
Montero Pérez-Barquero, Manuel
González Franco, Álvaro
Cerqueiro, José Manuel
Pérez Silvestre, José
Fernández Rodríguez, José María
Llàcer, Pau
Casado Cerrada, Jesús
Formiga Pérez, Francesc
Salamanca Bautista, Prado
Arévalo Lorido, José Carlos
Manzano Espinosa, Luis
author_role author
author2 Méndez Bailón, Manuel
Montero Pérez-Barquero, Manuel
González Franco, Álvaro
Cerqueiro, José Manuel
Pérez Silvestre, José
Fernández Rodríguez, José María
Llàcer, Pau
Casado Cerrada, Jesús
Formiga Pérez, Francesc
Salamanca Bautista, Prado
Arévalo Lorido, José Carlos
Manzano Espinosa, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiència cardíaca
Factors sexuals en les malalties
Heart failure
Sex factors in disease
topic Insuficiència cardíaca
Factors sexuals en les malalties
Heart failure
Sex factors in disease
description Background/Objectives: Heart failure (HF) is a leading cause of hospitalization in older adults, with significant sex differences in presentation, treatment, and outcomes. Transitional care models may benefit women more, yet they often receive less follow-up. This study assessed whether the clinical impact of the UMIPIC multidisciplinary HF management program differs by sex. Methods: This prospective, multicenter, observational cohort study included HF patients enrolled in the UMIPIC program or followed through conventional care in the RICA registry. Outcomes (30-day and one-year mortality and readmissions) were compared between groups, stratified by sex. Multivariate Cox models adjusted for age, HF phenotype, comorbidities, and baseline therapy. Results: A total of 5644 HF patients were included, with 2034 (36%) managed in UMIPIC and 3610 (64%) receiving conventional care. Women represented 55% of UMIPIC patients and were older, with higher prevalence of hypertension, anemia, and HF with preserved ejection fraction (HFpEF) compared to conventional care. At 30 days, women in UMIPIC had lower all-cause mortality (4.0% vs. 8.0%), cardiovascular mortality (2.0% vs. 6.0%), and readmissions (9.0% vs. 18.0%; all p < 0.01); these benefits persisted at one year. In multivariate analysis, UMIPIC enrollment remained protective (HR: 0.79; 95% CI: 0.71-0.87; p < 0.001). In men, UMIPIC patients were older with more comorbidities and higher HFpEF prevalence. They also showed lower 30-day mortality (2.0% vs. 8.0%; p < 0.05) and readmissions (8.0% vs. 18.0%; p < 0.01), with benefits maintained at one year. UMIPIC enrollment remained independently associated with reduced one-year mortality in men (HR: 0.79; 95% CI: 0.71-0.88; p < 0.001). Conclusions: The UMIPIC multidisciplinary care model reduced one-year mortality and readmissions in both women and men with HF, supporting integrated care strategies to improve outcomes in this high-risk population.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223346
http://hdl.handle.net/2445/223346
url https://hdl.handle.net/2445/223346
http://hdl.handle.net/2445/223346
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm14165818
Journal of Clinical Medicine, 2025, vol. 14, num. 16, 5818
https://doi.org/10.3390/jcm14165818
dc.rights.none.fl_str_mv cc-by (c) Conde Martel, Alicia et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Conde Martel, Alicia et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415431523008512
score 15,811543

Similares en LA Referencia