Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure
Background: Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unexplored. This study sought to investigate the association of TCA cycle-rel...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/115640 |
| Acceso en línea: | https://hdl.handle.net/10171/115640 |
| Access Level: | acceso abierto |
| Palabra clave: | Atrial fibrillation Heart failure Hydroxyglutarate PREDIMED Tricarboxylic acid cycle metabolites |
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| dc.title.none.fl_str_mv |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| title |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| spellingShingle |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure Bullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835 Atrial fibrillation Heart failure Hydroxyglutarate PREDIMED Tricarboxylic acid cycle metabolites |
| title_short |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| title_full |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| title_fullStr |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| title_full_unstemmed |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| title_sort |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure |
| dc.creator.none.fl_str_mv |
Bullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835 Papandreou, C. (Christopher)|||/items/40a83136-67a5-40ef-9745-724106540abb García-Gavilán, J.F. (Jesús F.)|||/items/9718a7cb-f470-49b0-b6bf-7771720eb20a Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Li, J. (Jun)|||/items/4d55731f-bea5-4170-9b0e-1b7d943f4c75 Guasch-Ferre, M. (Marta)|||/items/55c7d61d-930e-4894-92e6-429f5d71f807 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Clish, C.B. (Clary B.)|||/items/91a609cf-9023-48b1-a2cd-83cc210ebed4 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Ros, E. (Emilio)|||/items/8c9fcd5a-f4ca-4a48-8fad-4737d7d5ca7f Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Lee, C.H. (Chih-Hao)|||/items/b95e5cba-8b96-43a2-83b2-0a7434370742 Pierce, K.A. (Kerry A.)|||/items/00383d79-0a72-40ef-ba7f-2640c611d7f9 Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Serra-Majem, L. (Lluís)|||/items/e6a3f618-abe3-45ec-b2db-0c8cb55501ea Liang, L. (Liming)|||/items/ed4ee918-f3fc-4e03-bacf-8caba63580be Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hu, F.B. (Frank B.)|||/items/038ab309-7025-4457-a78e-835b9a1d8415 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 |
| author |
Bullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835 |
| author_facet |
Bullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835 Papandreou, C. (Christopher)|||/items/40a83136-67a5-40ef-9745-724106540abb García-Gavilán, J.F. (Jesús F.)|||/items/9718a7cb-f470-49b0-b6bf-7771720eb20a Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Li, J. (Jun)|||/items/4d55731f-bea5-4170-9b0e-1b7d943f4c75 Guasch-Ferre, M. (Marta)|||/items/55c7d61d-930e-4894-92e6-429f5d71f807 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Clish, C.B. (Clary B.)|||/items/91a609cf-9023-48b1-a2cd-83cc210ebed4 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Ros, E. (Emilio)|||/items/8c9fcd5a-f4ca-4a48-8fad-4737d7d5ca7f Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Lee, C.H. (Chih-Hao)|||/items/b95e5cba-8b96-43a2-83b2-0a7434370742 Pierce, K.A. (Kerry A.)|||/items/00383d79-0a72-40ef-ba7f-2640c611d7f9 Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Serra-Majem, L. (Lluís)|||/items/e6a3f618-abe3-45ec-b2db-0c8cb55501ea Liang, L. (Liming)|||/items/ed4ee918-f3fc-4e03-bacf-8caba63580be Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hu, F.B. (Frank B.)|||/items/038ab309-7025-4457-a78e-835b9a1d8415 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 |
| author_role |
author |
| author2 |
Papandreou, C. (Christopher)|||/items/40a83136-67a5-40ef-9745-724106540abb García-Gavilán, J.F. (Jesús F.)|||/items/9718a7cb-f470-49b0-b6bf-7771720eb20a Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Li, J. (Jun)|||/items/4d55731f-bea5-4170-9b0e-1b7d943f4c75 Guasch-Ferre, M. (Marta)|||/items/55c7d61d-930e-4894-92e6-429f5d71f807 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Clish, C.B. (Clary B.)|||/items/91a609cf-9023-48b1-a2cd-83cc210ebed4 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Ros, E. (Emilio)|||/items/8c9fcd5a-f4ca-4a48-8fad-4737d7d5ca7f Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Lee, C.H. (Chih-Hao)|||/items/b95e5cba-8b96-43a2-83b2-0a7434370742 Pierce, K.A. (Kerry A.)|||/items/00383d79-0a72-40ef-ba7f-2640c611d7f9 Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Serra-Majem, L. (Lluís)|||/items/e6a3f618-abe3-45ec-b2db-0c8cb55501ea Liang, L. (Liming)|||/items/ed4ee918-f3fc-4e03-bacf-8caba63580be Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Hu, F.B. (Frank B.)|||/items/038ab309-7025-4457-a78e-835b9a1d8415 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Atrial fibrillation Heart failure Hydroxyglutarate PREDIMED Tricarboxylic acid cycle metabolites |
| topic |
Atrial fibrillation Heart failure Hydroxyglutarate PREDIMED Tricarboxylic acid cycle metabolites |
| description |
Background: Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unexplored. This study sought to investigate the association of TCA cycle-related metabolites with risk of AF and HF. Methods: We used two nested case-control studies within the PREDIMED study. During a mean follow-up for about 10 years, 512 AF and 334 HF incident cases matched by age (±5 years), sex and recruitment center to 616 controls and 433 controls, respectively, were included in this study. Baseline plasma levels of citrate, aconitate, isocitrate, succinate, malate and d/l-2-hydroxyglutarate were measured with liquid chromatography-tandem mass spectrometry. Multivariable conditional logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for metabolites and the risk of AF or HF. Potential confounders included smoking, family history of premature coronary heart disease, physical activity, alcohol intake, body mass index, intervention groups, dyslipidemia, hypertension, type 2 diabetes and medication use. Results: Comparing extreme quartiles of metabolites, elevated levels of succinate, malate, citrate and d/l-2-hydroxyglutarate were associated with a higher risk of AF [ORQ4 vs. Q1 (95% CI): 1.80 (1.21-2.67), 2.13 (1.45-3.13), 1.87 (1.25-2.81) and 1.95 (1.31-2.90), respectively]. One SD increase in aconitate was directly associated with AF risk [OR (95% CI): 1.16 (1.01-1.34)]. The corresponding ORs (95% CI) for HF comparing extreme quartiles of malate, aconitate, isocitrate and d/l-2-hydroxyglutarate were 2.15 (1.29-3.56), 2.16 (1.25-3.72), 2.63 (1.56-4.44) and 1.82 (1.10-3.04), respectively. These associations were confirmed in an internal validation, except for aconitate and AF. Conclusion: These findings underscore the potential role of the TCA cycle in the pathogenesis of cardiac outcomes. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/115640 |
| url |
https://hdl.handle.net/10171/115640 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Grune & Stratton |
| publisher.none.fl_str_mv |
Grune & Stratton |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415430456606720 |
| spelling |
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failureBullo, M. (Monica)|||/items/d8fb42f6-4284-48ef-9dc1-e84db1841835Papandreou, C. (Christopher)|||/items/40a83136-67a5-40ef-9745-724106540abbGarcía-Gavilán, J.F. (Jesús F.)|||/items/9718a7cb-f470-49b0-b6bf-7771720eb20aRuiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9Li, J. (Jun)|||/items/4d55731f-bea5-4170-9b0e-1b7d943f4c75Guasch-Ferre, M. (Marta)|||/items/55c7d61d-930e-4894-92e6-429f5d71f807Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Clish, C.B. (Clary B.)|||/items/91a609cf-9023-48b1-a2cd-83cc210ebed4Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265Ros, E. (Emilio)|||/items/8c9fcd5a-f4ca-4a48-8fad-4737d7d5ca7fFito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6bLee, C.H. (Chih-Hao)|||/items/b95e5cba-8b96-43a2-83b2-0a7434370742Pierce, K.A. (Kerry A.)|||/items/00383d79-0a72-40ef-ba7f-2640c611d7f9Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ceSerra-Majem, L. (Lluís)|||/items/e6a3f618-abe3-45ec-b2db-0c8cb55501eaLiang, L. (Liming)|||/items/ed4ee918-f3fc-4e03-bacf-8caba63580beMartínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Hu, F.B. (Frank B.)|||/items/038ab309-7025-4457-a78e-835b9a1d8415Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Atrial fibrillationHeart failureHydroxyglutaratePREDIMEDTricarboxylic acid cycle metabolitesBackground: Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unexplored. This study sought to investigate the association of TCA cycle-related metabolites with risk of AF and HF. Methods: We used two nested case-control studies within the PREDIMED study. During a mean follow-up for about 10 years, 512 AF and 334 HF incident cases matched by age (±5 years), sex and recruitment center to 616 controls and 433 controls, respectively, were included in this study. Baseline plasma levels of citrate, aconitate, isocitrate, succinate, malate and d/l-2-hydroxyglutarate were measured with liquid chromatography-tandem mass spectrometry. Multivariable conditional logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for metabolites and the risk of AF or HF. Potential confounders included smoking, family history of premature coronary heart disease, physical activity, alcohol intake, body mass index, intervention groups, dyslipidemia, hypertension, type 2 diabetes and medication use. Results: Comparing extreme quartiles of metabolites, elevated levels of succinate, malate, citrate and d/l-2-hydroxyglutarate were associated with a higher risk of AF [ORQ4 vs. Q1 (95% CI): 1.80 (1.21-2.67), 2.13 (1.45-3.13), 1.87 (1.25-2.81) and 1.95 (1.31-2.90), respectively]. One SD increase in aconitate was directly associated with AF risk [OR (95% CI): 1.16 (1.01-1.34)]. The corresponding ORs (95% CI) for HF comparing extreme quartiles of malate, aconitate, isocitrate and d/l-2-hydroxyglutarate were 2.15 (1.29-3.56), 2.16 (1.25-3.72), 2.63 (1.56-4.44) and 1.82 (1.10-3.04), respectively. These associations were confirmed in an internal validation, except for aconitate and AF. Conclusion: These findings underscore the potential role of the TCA cycle in the pathogenesis of cardiac outcomes.Grune & StrattonDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/115640reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1156402026-06-21T12:47:57Z |
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15,811543 |