Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation

γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also...

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Autores: Garcia-Herrera, Adriana, Song, Joo Y., Chuang, Shih-Sung, Villamor, Neus, Colomo Saperas, Luis Alberto, Pittaluga, Stefania, Alvaro, Tomas, Rozman, Maria, Anda Gonzalez, Jazmin de, Arrunategui, Ana Maria, Fernandez, Eva, Gonzalvo, Elena, Estrach, Teresa, Colomer Pujol, Dolors, Raffeld, Mark, Gaulard, Philippe, Campo, Elias, Jaffe, Elaine S., Martinez, Antonio
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2011
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/37082
Acesso em linha:http://hdl.handle.net/10230/37082
http://dx.doi.org/10.1097/PAS.0b013e31822067d1
Access Level:Acceso aberto
Palavra-chave:Limfomes
Receptors cel·lulars
Pell -- Càncer
Limfòcits
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spelling Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentationGarcia-Herrera, AdrianaSong, Joo Y.Chuang, Shih-SungVillamor, NeusColomo Saperas, Luis AlbertoPittaluga, StefaniaAlvaro, TomasRozman, MariaAnda Gonzalez, Jazmin deArrunategui, Ana MariaFernandez, EvaGonzalvo, ElenaEstrach, TeresaColomer Pujol, DolorsRaffeld, MarkGaulard, PhilippeCampo, EliasJaffe, Elaine S.Martinez, AntonioLimfomesReceptors cel·lularsPell -- CàncerLimfòcitsγδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy-associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.Supported by Instituto de Salud Carlos III, Fondo de Investigación Sanitaria) PI080095 (AM) and PI050458 (TE). The Spanish Comisión Interministerial de Ciencia y Tecnología (CICYT) SAF08-3630 (EC), Red Temática de Investigación Cooperativa del Cáncer (RTICC) RD06/0020/0039 (EC), AGH is a fellow supported by the Instituto de Salud Carlos III. This work was also supported by the Intramural Research Program of the Center for Cancer Research, National Cancer InstituteLippincott Williams & Wilkins201920192011info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/37082http://dx.doi.org/10.1097/PAS.0b013e31822067d1reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThe American Journal of Surgical Pathology. 2011 Aug;35(8):1214-25© Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Garcia-Herrera A, Song JY, Chuang SS, Villamor N, Colomo L, Pittaluga S et al. Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011 Aug; 35(8): 1214-25. http://dx.doi.org/10.1097/PAS.0b013e31822067d1info:eu-repo/semantics/openAccessoai:recercat.cat:10230/370822026-05-29T05:05:01Z
dc.title.none.fl_str_mv Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
title Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
spellingShingle Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
Garcia-Herrera, Adriana
Limfomes
Receptors cel·lulars
Pell -- Càncer
Limfòcits
title_short Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
title_full Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
title_fullStr Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
title_full_unstemmed Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
title_sort Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
dc.creator.none.fl_str_mv Garcia-Herrera, Adriana
Song, Joo Y.
Chuang, Shih-Sung
Villamor, Neus
Colomo Saperas, Luis Alberto
Pittaluga, Stefania
Alvaro, Tomas
Rozman, Maria
Anda Gonzalez, Jazmin de
Arrunategui, Ana Maria
Fernandez, Eva
Gonzalvo, Elena
Estrach, Teresa
Colomer Pujol, Dolors
Raffeld, Mark
Gaulard, Philippe
Campo, Elias
Jaffe, Elaine S.
Martinez, Antonio
author Garcia-Herrera, Adriana
author_facet Garcia-Herrera, Adriana
Song, Joo Y.
Chuang, Shih-Sung
Villamor, Neus
Colomo Saperas, Luis Alberto
Pittaluga, Stefania
Alvaro, Tomas
Rozman, Maria
Anda Gonzalez, Jazmin de
Arrunategui, Ana Maria
Fernandez, Eva
Gonzalvo, Elena
Estrach, Teresa
Colomer Pujol, Dolors
Raffeld, Mark
Gaulard, Philippe
Campo, Elias
Jaffe, Elaine S.
Martinez, Antonio
author_role author
author2 Song, Joo Y.
Chuang, Shih-Sung
Villamor, Neus
Colomo Saperas, Luis Alberto
Pittaluga, Stefania
Alvaro, Tomas
Rozman, Maria
Anda Gonzalez, Jazmin de
Arrunategui, Ana Maria
Fernandez, Eva
Gonzalvo, Elena
Estrach, Teresa
Colomer Pujol, Dolors
Raffeld, Mark
Gaulard, Philippe
Campo, Elias
Jaffe, Elaine S.
Martinez, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Limfomes
Receptors cel·lulars
Pell -- Càncer
Limfòcits
topic Limfomes
Receptors cel·lulars
Pell -- Càncer
Limfòcits
description γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy-associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
publishDate 2011
dc.date.none.fl_str_mv 2011
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/37082
http://dx.doi.org/10.1097/PAS.0b013e31822067d1
url http://hdl.handle.net/10230/37082
http://dx.doi.org/10.1097/PAS.0b013e31822067d1
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The American Journal of Surgical Pathology. 2011 Aug;35(8):1214-25
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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