Regulatory cells and the effect of cancer immunotherapy

Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell types such as tolerogenic dendritic cells (tolDCs), regulatory B cells...

Descripción completa

Detalles Bibliográficos
Autores: Iglesias-Escudero, María, Arias-González, Noelia, Martínez Cáceres, Eva María|||0000-0002-6762-8025
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:273934
Acceso en línea:https://ddd.uab.cat/record/273934
https://dx.doi.org/urn:doi:10.1186/s12943-023-01714-0
Access Level:acceso abierto
Palabra clave:Tumor
Immunotherapy
Regulatory cells
Checkpoint inhibitors
MDSCs
Tregs
TAMs
id ES_a3c280c22600e2cfb83d43944a472daf
oai_identifier_str oai:ddd.uab.cat:273934
network_acronym_str ES
network_name_str España
repository_id_str
spelling Regulatory cells and the effect of cancer immunotherapyIglesias-Escudero, MaríaArias-González, NoeliaMartínez Cáceres, Eva María|||0000-0002-6762-8025TumorImmunotherapyRegulatory cellsCheckpoint inhibitorsMDSCsTregsTAMsSeveral mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell types such as tolerogenic dendritic cells (tolDCs), regulatory B cells (Bregs), and mesenchymal stem cells (MSCs). These regulatory cells, known for their ability to suppress immune responses, can also suppress the anti-tumor immune response. The infiltration of many regulatory cells into tumor tissues is therefore associated with a poor prognosis. There is growing evidence that elimination of Tregs enhances anti-tumor immune responses. However, the systemic depletion of Treg cells can simultaneously cause deleterious autoimmunity. Furthermore, since regulatory cells are characterized by their high level of expression of immune checkpoints, it is also expected that immune checkpoint inhibitors perform part of their function by blocking these molecules and enhancing the immune response. This indicates that immunotherapy does not only act by activating specific effector T cells but can also directly or indirectly attenuate the suppressive activity of regulatory cells in tumor tissues. This review aims to draw together our current knowledge about the effect of immunotherapy on the various types of regulatory cells, and how these effects may be beneficial in the response to immunotherapy. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/273934https://dx.doi.org/urn:doi:10.1186/s12943-023-01714-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2739342026-06-06T12:50:31Z
dc.title.none.fl_str_mv Regulatory cells and the effect of cancer immunotherapy
title Regulatory cells and the effect of cancer immunotherapy
spellingShingle Regulatory cells and the effect of cancer immunotherapy
Iglesias-Escudero, María
Tumor
Immunotherapy
Regulatory cells
Checkpoint inhibitors
MDSCs
Tregs
TAMs
title_short Regulatory cells and the effect of cancer immunotherapy
title_full Regulatory cells and the effect of cancer immunotherapy
title_fullStr Regulatory cells and the effect of cancer immunotherapy
title_full_unstemmed Regulatory cells and the effect of cancer immunotherapy
title_sort Regulatory cells and the effect of cancer immunotherapy
dc.creator.none.fl_str_mv Iglesias-Escudero, María
Arias-González, Noelia
Martínez Cáceres, Eva María|||0000-0002-6762-8025
author Iglesias-Escudero, María
author_facet Iglesias-Escudero, María
Arias-González, Noelia
Martínez Cáceres, Eva María|||0000-0002-6762-8025
author_role author
author2 Arias-González, Noelia
Martínez Cáceres, Eva María|||0000-0002-6762-8025
author2_role author
author
dc.subject.none.fl_str_mv Tumor
Immunotherapy
Regulatory cells
Checkpoint inhibitors
MDSCs
Tregs
TAMs
topic Tumor
Immunotherapy
Regulatory cells
Checkpoint inhibitors
MDSCs
Tregs
TAMs
description Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell types such as tolerogenic dendritic cells (tolDCs), regulatory B cells (Bregs), and mesenchymal stem cells (MSCs). These regulatory cells, known for their ability to suppress immune responses, can also suppress the anti-tumor immune response. The infiltration of many regulatory cells into tumor tissues is therefore associated with a poor prognosis. There is growing evidence that elimination of Tregs enhances anti-tumor immune responses. However, the systemic depletion of Treg cells can simultaneously cause deleterious autoimmunity. Furthermore, since regulatory cells are characterized by their high level of expression of immune checkpoints, it is also expected that immune checkpoint inhibitors perform part of their function by blocking these molecules and enhancing the immune response. This indicates that immunotherapy does not only act by activating specific effector T cells but can also directly or indirectly attenuate the suppressive activity of regulatory cells in tumor tissues. This review aims to draw together our current knowledge about the effect of immunotherapy on the various types of regulatory cells, and how these effects may be beneficial in the response to immunotherapy.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/273934
https://dx.doi.org/urn:doi:10.1186/s12943-023-01714-0
url https://ddd.uab.cat/record/273934
https://dx.doi.org/urn:doi:10.1186/s12943-023-01714-0
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415423598919680
score 15,300719

Similares en LA Referencia