Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat

When danger is perceived, the human body responds to overcome obstacles and survive a stressful situation; however, sustained levels of stress are associated with health disorders and diminished life quality. Hence, stress biomarkers are monitored to control stress quantitatively. Herein, a porous s...

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Autores: Borràs Cristòfol, Núria|||0000-0002-4015-6611, Sánchez Jiménez, Margarita|||0000-0003-4375-6230, Casanovas Salas, Jordi|||0000-0002-4914-9194, Alemán Llansó, Carlos|||0000-0003-4462-6075, Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/375487
Acesso em linha:https://hdl.handle.net/2117/375487
https://dx.doi.org/10.1002/mame.202200269
Access Level:acceso abierto
Palavra-chave:Biochemical markers
Marcadors bioquímics
Àrees temàtiques de la UPC::Enginyeria química
Àrees temàtiques de la UPC::Enginyeria biomèdica
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repository_id_str
spelling Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweatBorràs Cristòfol, Núria|||0000-0002-4015-6611Sánchez Jiménez, Margarita|||0000-0003-4375-6230Casanovas Salas, Jordi|||0000-0002-4914-9194Alemán Llansó, Carlos|||0000-0003-4462-6075Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485Biochemical markersMarcadors bioquímicsÀrees temàtiques de la UPC::Enginyeria químicaÀrees temàtiques de la UPC::Enginyeria biomèdicaWhen danger is perceived, the human body responds to overcome obstacles and survive a stressful situation; however, sustained levels of stress are associated with health disorders and diminished life quality. Hence, stress biomarkers are monitored to control stress quantitatively. Herein, a porous sensor (4l-COP/p) composed of poly(3,4-ethylenedioxythiophene) (PEDOT) and poly(3,4-ethylenedioxythiophene-co-N-methylpyrrole) (COP), which is prepared in a four-layered fashion to detect dopamine (DA) and serotonin (5-HT), is presented. Specifically, the detection is conducted in phosphate-buffered saline (PBS), as well as artificial urine and sweat, by applying cyclic voltammetry. The limit of detection values obtained are as low as 5.7 × 10-6 and 1.4 × 10-6 m for DA and 5-HT, respectively, when assessed individually in artificial urine. When mixed in PBS, 4l-COP/p detects both biomarkers with a resolution of 0.18 V and a sensitivity of 40 and 30 µA mm-1 for DA and 5-HT, respectively. Additionally, by theoretical calculations, the interaction pattern that each stress biomarker establishes with the PEDOT outer layer is elucidated. Whereas DA interacts with the p-system of PEDOT, 5-HT forms specific hydrogen bonds with the conducting polymer chains. The resolution value obtained depends upon such interactions. Overall, 4l-COP/p electrodes display potential as stress sensing devices for healthcare technologies.Peer Reviewed20222022-10-0320222022-11-03journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/375487https://dx.doi.org/10.1002/mame.202200269reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3754872026-05-27T15:37:01Z
dc.title.none.fl_str_mv Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
title Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
spellingShingle Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
Borràs Cristòfol, Núria|||0000-0002-4015-6611
Biochemical markers
Marcadors bioquímics
Àrees temàtiques de la UPC::Enginyeria química
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
title_full Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
title_fullStr Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
title_full_unstemmed Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
title_sort Porous poly(3,4-ethylenedioxythiophene)-based electrodes for detecting stress biomarkers in artificial urine and sweat
dc.creator.none.fl_str_mv Borràs Cristòfol, Núria|||0000-0002-4015-6611
Sánchez Jiménez, Margarita|||0000-0003-4375-6230
Casanovas Salas, Jordi|||0000-0002-4914-9194
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author Borràs Cristòfol, Núria|||0000-0002-4015-6611
author_facet Borràs Cristòfol, Núria|||0000-0002-4015-6611
Sánchez Jiménez, Margarita|||0000-0003-4375-6230
Casanovas Salas, Jordi|||0000-0002-4914-9194
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author_role author
author2 Sánchez Jiménez, Margarita|||0000-0003-4375-6230
Casanovas Salas, Jordi|||0000-0002-4914-9194
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biochemical markers
Marcadors bioquímics
Àrees temàtiques de la UPC::Enginyeria química
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Biochemical markers
Marcadors bioquímics
Àrees temàtiques de la UPC::Enginyeria química
Àrees temàtiques de la UPC::Enginyeria biomèdica
description When danger is perceived, the human body responds to overcome obstacles and survive a stressful situation; however, sustained levels of stress are associated with health disorders and diminished life quality. Hence, stress biomarkers are monitored to control stress quantitatively. Herein, a porous sensor (4l-COP/p) composed of poly(3,4-ethylenedioxythiophene) (PEDOT) and poly(3,4-ethylenedioxythiophene-co-N-methylpyrrole) (COP), which is prepared in a four-layered fashion to detect dopamine (DA) and serotonin (5-HT), is presented. Specifically, the detection is conducted in phosphate-buffered saline (PBS), as well as artificial urine and sweat, by applying cyclic voltammetry. The limit of detection values obtained are as low as 5.7 × 10-6 and 1.4 × 10-6 m for DA and 5-HT, respectively, when assessed individually in artificial urine. When mixed in PBS, 4l-COP/p detects both biomarkers with a resolution of 0.18 V and a sensitivity of 40 and 30 µA mm-1 for DA and 5-HT, respectively. Additionally, by theoretical calculations, the interaction pattern that each stress biomarker establishes with the PEDOT outer layer is elucidated. Whereas DA interacts with the p-system of PEDOT, 5-HT forms specific hydrogen bonds with the conducting polymer chains. The resolution value obtained depends upon such interactions. Overall, 4l-COP/p electrodes display potential as stress sensing devices for healthcare technologies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-10-03
2022
2022-11-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/375487
https://dx.doi.org/10.1002/mame.202200269
url https://hdl.handle.net/2117/375487
https://dx.doi.org/10.1002/mame.202200269
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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