Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters

García-Talavera San Miguel, Paloma; Diaz Soto, Gonzalo; Montes Tomé, Arnold Antonio; Villanueva Curto, Juan Gabriel; Cobo, Amparo; Gamazo, Claudia; Ruiz, María Ángeles; González Selma, María Luisa

Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters

[EN]Aim To evaluate the value of 99mTc-MIBI double-phase scintigraphy (DPS) and early SPECT/CT in the pre-surgical assessment of patients with primary hyperparathyroidism (PHPT). Also, to calculate the correlation between uptake and some biological parameters. Material and methods Forty patients wit...

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Autores:	García-Talavera San Miguel, Paloma, Diaz Soto, Gonzalo, Montes Tomé, Arnold Antonio, Villanueva Curto, Juan Gabriel, Cobo, Amparo, Gamazo, Claudia, Ruiz, María Ángeles, González Selma, María Luisa
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	España
Recursos:	Universidad de Salamanca (USAL)
Repositorio:	GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:	oai:gredos.usal.es:10366/166703
Acesso em linha:	http://hdl.handle.net/10366/166703
Access Level:	acceso abierto
Palavra-chave:	Early SPECT/CT 99mTc-MIBI double-phase scintigraphy Primary hyperparathyroidism iPTH Glandular size SPECT/TC precoz Gammagrafía de doble fase con 99mTc-MIBI Hiperparatiroidimo primario PTHi Tamaño glandular Hyperparathyroidism, Primary Technetium Tc 99m Sestamibi 32 Ciencias Médicas sestamibi de tecnecio Tc 99m hiperparatiroidismo primario

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network_acronym_str	ES
network_name_str	España
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dc.title.none.fl_str_mv	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters Aportación del SPECT/TC precoz a la gammagrafía de doble fase con 99mTc-MIBI en pacientes con hiperparatiroidismo primario: valor diagnóstico y correlación de la captación con parámetros biológicos
title	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
spellingShingle	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters García-Talavera San Miguel, Paloma Early SPECT/CT 99mTc-MIBI double-phase scintigraphy Primary hyperparathyroidism iPTH Glandular size SPECT/TC precoz Gammagrafía de doble fase con 99mTc-MIBI Hiperparatiroidimo primario PTHi Tamaño glandular Hyperparathyroidism, Primary Technetium Tc 99m Sestamibi 32 Ciencias Médicas sestamibi de tecnecio Tc 99m hiperparatiroidismo primario
title_short	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
title_full	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
title_fullStr	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
title_full_unstemmed	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
title_sort	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters
dc.creator.none.fl_str_mv	García-Talavera San Miguel, Paloma Diaz Soto, Gonzalo Montes Tomé, Arnold Antonio Villanueva Curto, Juan Gabriel Cobo, Amparo Gamazo, Claudia Ruiz, María Ángeles González Selma, María Luisa
author	García-Talavera San Miguel, Paloma
author_facet	García-Talavera San Miguel, Paloma Diaz Soto, Gonzalo Montes Tomé, Arnold Antonio Villanueva Curto, Juan Gabriel Cobo, Amparo Gamazo, Claudia Ruiz, María Ángeles González Selma, María Luisa
author_role	author
author2	Diaz Soto, Gonzalo Montes Tomé, Arnold Antonio Villanueva Curto, Juan Gabriel Cobo, Amparo Gamazo, Claudia Ruiz, María Ángeles González Selma, María Luisa
author2_role	author author author author author author author
dc.subject.none.fl_str_mv	Early SPECT/CT 99mTc-MIBI double-phase scintigraphy Primary hyperparathyroidism iPTH Glandular size SPECT/TC precoz Gammagrafía de doble fase con 99mTc-MIBI Hiperparatiroidimo primario PTHi Tamaño glandular Hyperparathyroidism, Primary Technetium Tc 99m Sestamibi 32 Ciencias Médicas sestamibi de tecnecio Tc 99m hiperparatiroidismo primario
topic	Early SPECT/CT 99mTc-MIBI double-phase scintigraphy Primary hyperparathyroidism iPTH Glandular size SPECT/TC precoz Gammagrafía de doble fase con 99mTc-MIBI Hiperparatiroidimo primario PTHi Tamaño glandular Hyperparathyroidism, Primary Technetium Tc 99m Sestamibi 32 Ciencias Médicas sestamibi de tecnecio Tc 99m hiperparatiroidismo primario
description	[EN]Aim To evaluate the value of 99mTc-MIBI double-phase scintigraphy (DPS) and early SPECT/CT in the pre-surgical assessment of patients with primary hyperparathyroidism (PHPT). Also, to calculate the correlation between uptake and some biological parameters. Material and methods Forty patients with PHPT were included: 37 solitary adenomas, 1 hyperplasia, and 2 double adenomas. Fifteen patients had ectopic glands. DPS and early SPECT/CT were acquired in all patients. Ultrasound was performed in 31/40. All patients underwent surgery, intra-operative iPTH measurements, and histopathological examinations. Qualitative DPS uptake was assessed and correlated to pre-surgical calcium, iPTH levels, gland weight, and maximum diameter. Results In the planar study, there were 23 positive cases, 8 doubtful, and 9 negatives. With the SPECT/CT, 8/9 negatives cases were located. All doubtful cases were confirmed as positives. Gland location improved in 16 cases (12 ectopic). DPS + SPECT/CT failed to detect a solitary adenoma and at least one gland in three cases of multiglandular disease (MGD). The sensitivity by patient was: DPS 72.5%, DPS + SPECT/CT 90%, and ultrasound 42%. Ultrasound and scintigraphy (DPS + SPECT/CT) were concordant in 16/31 patients. For the rest of them, scintigraphy proved correct in 14/15, and both techniques failed in one case. There was a significant correlation between level of uptake and iPTH level, gland weight, and maximum diameter. Conclusion Early SPECT/CT improves sensitivity and the locating of parathyroid pathological glands and increases diagnostic confidence. iPTH level, glandular size, and weight are related to the qualitative assessment of 99mTc-MIBI uptake in early DPS.
publishDate	2016
dc.date.none.fl_str_mv	2016 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10366/166703
url	http://hdl.handle.net/10366/166703
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL)
instname_str	Universidad de Salamanca (USAL)
reponame_str	GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection	GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parametersAportación del SPECT/TC precoz a la gammagrafía de doble fase con 99mTc-MIBI en pacientes con hiperparatiroidismo primario: valor diagnóstico y correlación de la captación con parámetros biológicosGarcía-Talavera San Miguel, PalomaDiaz Soto, GonzaloMontes Tomé, Arnold AntonioVillanueva Curto, Juan GabrielCobo, AmparoGamazo, ClaudiaRuiz, María ÁngelesGonzález Selma, María LuisaEarly SPECT/CT99mTc-MIBI double-phase scintigraphyPrimary hyperparathyroidismiPTHGlandular sizeSPECT/TC precozGammagrafía de doble fase con 99mTc-MIBIHiperparatiroidimo primarioPTHiTamaño glandularHyperparathyroidism, PrimaryTechnetium Tc 99m Sestamibi32 Ciencias Médicassestamibi de tecnecio Tc 99mhiperparatiroidismo primario[EN]Aim To evaluate the value of 99mTc-MIBI double-phase scintigraphy (DPS) and early SPECT/CT in the pre-surgical assessment of patients with primary hyperparathyroidism (PHPT). Also, to calculate the correlation between uptake and some biological parameters. Material and methods Forty patients with PHPT were included: 37 solitary adenomas, 1 hyperplasia, and 2 double adenomas. Fifteen patients had ectopic glands. DPS and early SPECT/CT were acquired in all patients. Ultrasound was performed in 31/40. All patients underwent surgery, intra-operative iPTH measurements, and histopathological examinations. Qualitative DPS uptake was assessed and correlated to pre-surgical calcium, iPTH levels, gland weight, and maximum diameter. Results In the planar study, there were 23 positive cases, 8 doubtful, and 9 negatives. With the SPECT/CT, 8/9 negatives cases were located. All doubtful cases were confirmed as positives. Gland location improved in 16 cases (12 ectopic). DPS + SPECT/CT failed to detect a solitary adenoma and at least one gland in three cases of multiglandular disease (MGD). The sensitivity by patient was: DPS 72.5%, DPS + SPECT/CT 90%, and ultrasound 42%. Ultrasound and scintigraphy (DPS + SPECT/CT) were concordant in 16/31 patients. For the rest of them, scintigraphy proved correct in 14/15, and both techniques failed in one case. There was a significant correlation between level of uptake and iPTH level, gland weight, and maximum diameter. Conclusion Early SPECT/CT improves sensitivity and the locating of parathyroid pathological glands and increases diagnostic confidence. iPTH level, glandular size, and weight are related to the qualitative assessment of 99mTc-MIBI uptake in early DPS.[ES]Objetivo Evaluar la gammagrafía de doble fase con 99mTc-MIBI (GDF) y el SPECT/TC precoz, en la valoración prequirúrgica del hiperparatiroidismo primario (HPTP), calculando la correlación entre grado de captación y algunos parámetros biológicos. Material y métodos Se incluyeron 40 pacientes: 37 adenomas solitarios, dos adenomas dobles, una hiperplasia. Quince tenían glándulas ectópicas. En 40 pacientes se realizaron GDF y SPECT/TC; en 31/40, ecografía. Todos los pacientes fueron intervenidos, realizando determinación de PTHi intraoperatoria y examen histopatológico. Se evaluó cualitativamente la captación en la GDF, correlacionándose con calcio y PTHi prequirúrgicos, peso y diámetro máximo glandulares. Resultados En el estudio planar se obtuvieron 23 casos positivos, 8 dudosos, y 9 negativos. Con SPECT/TC se localizaron 8/9 de los negativos. Todos los dudosos se confirmaron como positivos. La localización glandular mejoró en 16 casos (12 ectópicos). La GDF + SPECT/TC fallaron en la detección de un adenoma solitario y en la visualización de alguna de las glándulas en tres casos de enfermedad multiglandular (EMG). La sensibilidad por pacientes fue: GDF 72,5%, GDF + SPECT/TC 90%, ecografía 42%. Ecografía y gammagrafía (GDF + SPECT/TC) concordaron en 16/31 pacientes. De los no concordantes, la gammagrafía acertó en 14/15 y ambas técnicas fallaron en uno. Hubo correlación significativa entre captación y PTHi, peso y diámetro máximo glandulares. Conclusion El SPECT/TC precoz mejora la sensibilidad y la localización de las paratiroides patológicas y aumenta la confianza diagnóstica. PTHi, tamaño y peso glandulares se correlacionan con la valoración cualitativa de la captación precoz de 99mTc-MIBI en la GDF.Elsevier202520252016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/166703reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1667032026-06-07T06:28:51Z
score	15.812429

Contribution of early SPECT/CT to 99mTc-MIBI double phase scintigraphy in primary hyperparathyroidism: Diagnostic value and correlation between uptake and biological parameters

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