Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance

Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD...

Descripción completa

Detalles Bibliográficos
Autores: Salvat Pujol, Neus, Labad, Javier, Urretavizcaya Sarachaga, Mikel, Arriba Arnau, Aida de, Segalàs Cosi, Cinto, Real, Eva, Ferrer, Alex, Crespo, José M., Jiménez-Murcia, Susana, Soriano Mas, Carles, Menchón Magriñá, José Manuel, Soria, Virginia
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/176092
Acceso en línea:https://hdl.handle.net/2445/176092
Access Level:acceso abierto
Palabra clave:Maltractament infantil
Depressió psíquica
Trastorns cognitius
Child abuse
Cognition disorders
Mental depression
id ES_a3b13f492fd95d28ff36e63ceb6cfc2a
oai_identifier_str oai:recercat.cat:2445/176092
network_acronym_str ES
network_name_str España
repository_id_str
spelling Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performanceSalvat Pujol, NeusLabad, JavierUrretavizcaya Sarachaga, MikelArriba Arnau, Aida deSegalàs Cosi, CintoReal, EvaFerrer, AlexCrespo, José M.Jiménez-Murcia, SusanaSoriano Mas, CarlesMenchón Magriñá, José ManuelSoria, VirginiaMaltractament infantilDepressió psíquicaTrastorns cognitiusChild abuseCognition disordersMental depressionBackground: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.Informa UK Limited2021202120212021info:eu-repo/semantics/article16 p.application/pdfhttps://hdl.handle.net/2445/176092Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1080/20008198.2020.1857955European Journal of Psychotraumatology, 2021, vol. 12, issue. 1, p. 1857955https://doi.org/10.1080/20008198.2020.1857955cc by-nc (c) Salvat Pujol, Neus et al.; 2021http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1760922026-05-29T05:05:01Z
dc.title.none.fl_str_mv Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
title Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
spellingShingle Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
Salvat Pujol, Neus
Maltractament infantil
Depressió psíquica
Trastorns cognitius
Child abuse
Cognition disorders
Mental depression
title_short Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
title_full Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
title_fullStr Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
title_full_unstemmed Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
title_sort Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
dc.creator.none.fl_str_mv Salvat Pujol, Neus
Labad, Javier
Urretavizcaya Sarachaga, Mikel
Arriba Arnau, Aida de
Segalàs Cosi, Cinto
Real, Eva
Ferrer, Alex
Crespo, José M.
Jiménez-Murcia, Susana
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Soria, Virginia
author Salvat Pujol, Neus
author_facet Salvat Pujol, Neus
Labad, Javier
Urretavizcaya Sarachaga, Mikel
Arriba Arnau, Aida de
Segalàs Cosi, Cinto
Real, Eva
Ferrer, Alex
Crespo, José M.
Jiménez-Murcia, Susana
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Soria, Virginia
author_role author
author2 Labad, Javier
Urretavizcaya Sarachaga, Mikel
Arriba Arnau, Aida de
Segalàs Cosi, Cinto
Real, Eva
Ferrer, Alex
Crespo, José M.
Jiménez-Murcia, Susana
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Soria, Virginia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Maltractament infantil
Depressió psíquica
Trastorns cognitius
Child abuse
Cognition disorders
Mental depression
topic Maltractament infantil
Depressió psíquica
Trastorns cognitius
Child abuse
Cognition disorders
Mental depression
description Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176092
url https://hdl.handle.net/2445/176092
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1080/20008198.2020.1857955
European Journal of Psychotraumatology, 2021, vol. 12, issue. 1, p. 1857955
https://doi.org/10.1080/20008198.2020.1857955
dc.rights.none.fl_str_mv cc by-nc (c) Salvat Pujol, Neus et al.; 2021
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Salvat Pujol, Neus et al.; 2021
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
dc.publisher.none.fl_str_mv Informa UK Limited
publisher.none.fl_str_mv Informa UK Limited
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869415418303610880
score 15.812429

Similares en LA Referencia