Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments

© The Author(s) 2021.

Detalles Bibliográficos
Autores: Delgado Blas, J. F., Ovejero, Cristina M., David, Sophia, Montero, Natalia, Calero-Caceres, William, Garcillán-Barcia, M. Pilar, Cruz, Fernando de la, Muniesa, Maite, Aanensen, David M., Gonzalez-Zorn, B.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/262608
Acceso en línea:http://hdl.handle.net/10261/262608
Access Level:acceso abierto
Palabra clave:Antimicrobial resistance
Bacterial genomics
Microbial ecology
Water microbiology
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spelling Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environmentsDelgado Blas, J. F.Ovejero, Cristina M.David, SophiaMontero, NataliaCalero-Caceres, WilliamGarcillán-Barcia, M. PilarCruz, Fernando de laMuniesa, MaiteAanensen, David M.Gonzalez-Zorn, B.Antimicrobial resistanceBacterial genomicsMicrobial ecologyWater microbiology© The Author(s) 2021.Aquatic environments are key niches for the emergence, evolution and dissemination of antimicrobial resistance. However, the population diversity and the genetic elements that drive the dynamics of resistant bacteria in different aquatic environments are still largely unknown. The aim of this study was to understand the population genomics and evolutionary events of Escherichia coli resistant to clinically important antibiotics including aminoglycosides, in anthropogenic and natural water ecosystems. Here we show that less different E. coli sequence types (STs) are identified in wastewater than in rivers, albeit more resistant to antibiotics, and with significantly more plasmids/cell (6.36 vs 3.72). However, the genomic diversity within E. coli STs in both aquatic environments is similar. Wastewater environments favor the selection of conserved chromosomal structures associated with diverse flexible plasmids, unraveling promiscuous interplasmidic resistance genes flux. On the contrary, the key driver for river E. coli adaptation is a mutable chromosome along with few plasmid types shared between diverse STs harboring a limited resistance gene content.Work carried out in the Institute of Biomedicine and Biotechnology (IBBTEC) was funded by the Ministry of Economy and Competitiveness (grant BFU2017-86378-P). The work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO BES-2015-073164) and the European Union’s Horizon 2020 Research and Innovation Programme (grant 773830, OH-EJP-H2020-JRP-AMR-2-WORLDCOM).Nature Publishing GroupMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Economía y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/262608reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-86378-Pinfo:eu-repo/grantAgreement/MINECO//BES-2015-073164info:eu-repo/grantAgreement/EC/H2020/773830http://dx.doi.org/10.1038/s42003-021-01949-xSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2626082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
title Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
spellingShingle Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
Delgado Blas, J. F.
Antimicrobial resistance
Bacterial genomics
Microbial ecology
Water microbiology
title_short Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
title_full Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
title_fullStr Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
title_full_unstemmed Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
title_sort Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments
dc.creator.none.fl_str_mv Delgado Blas, J. F.
Ovejero, Cristina M.
David, Sophia
Montero, Natalia
Calero-Caceres, William
Garcillán-Barcia, M. Pilar
Cruz, Fernando de la
Muniesa, Maite
Aanensen, David M.
Gonzalez-Zorn, B.
author Delgado Blas, J. F.
author_facet Delgado Blas, J. F.
Ovejero, Cristina M.
David, Sophia
Montero, Natalia
Calero-Caceres, William
Garcillán-Barcia, M. Pilar
Cruz, Fernando de la
Muniesa, Maite
Aanensen, David M.
Gonzalez-Zorn, B.
author_role author
author2 Ovejero, Cristina M.
David, Sophia
Montero, Natalia
Calero-Caceres, William
Garcillán-Barcia, M. Pilar
Cruz, Fernando de la
Muniesa, Maite
Aanensen, David M.
Gonzalez-Zorn, B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Antimicrobial resistance
Bacterial genomics
Microbial ecology
Water microbiology
topic Antimicrobial resistance
Bacterial genomics
Microbial ecology
Water microbiology
description © The Author(s) 2021.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/262608
url http://hdl.handle.net/10261/262608
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-86378-P
info:eu-repo/grantAgreement/MINECO//BES-2015-073164
info:eu-repo/grantAgreement/EC/H2020/773830
http://dx.doi.org/10.1038/s42003-021-01949-x
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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