CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination
CD25(+) regulatory T (T reg) cells suppress the activation/proliferation of other CD4(+) or CD8(+) T cells in vitro. Also, down-regulation of CD25(+) T reg cells enhance antitumor immune responses. In this study, we show that depletion of CD25(+) T reg cells allows the host to induce both CD4(+) and...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2003 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/20411 |
| Acceso en línea: | https://hdl.handle.net/10171/20411 |
| Access Level: | acceso abierto |
| Palabra clave: | Angiogenesis Inhibitors/physiology CD4-Positive T-Lymphocytes/immunology Colonic Neoplasms/immunology Down-Regulation/immunology Interferon-gamma/physiology Lymphocyte Activation/immunology Peptides/immunology Receptors, Interleukin-2/biosynthesis T-Lymphocyte Subsets/immunology |
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CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccinationCasares-Lagar, N. (Noelia)|||/items/32524a9b-f393-47ee-bf77-0737c65e0b7bArribillaga, L. (Laura)|||/items/a1a55d50-66c3-4216-9968-07b0c7f976ccSarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160Dotor, J. (Javier)|||/items/6606b7a3-73b7-49d9-bc1b-c565b3e1c208Lopez-Diaz-de-Cerio, A. (Ascensión)|||/items/29ab6acb-fcbb-43ff-b4c1-e2dc95e22bcbMelero, I. (Ignacio)|||/items/82113ea8-7ce1-49d5-9ee3-42cf20db1c4eLasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0cAngiogenesis Inhibitors/physiologyCD4-Positive T-Lymphocytes/immunologyColonic Neoplasms/immunologyDown-Regulation/immunologyInterferon-gamma/physiologyLymphocyte Activation/immunologyPeptides/immunologyReceptors, Interleukin-2/biosynthesisT-Lymphocyte Subsets/immunologyCD25(+) regulatory T (T reg) cells suppress the activation/proliferation of other CD4(+) or CD8(+) T cells in vitro. Also, down-regulation of CD25(+) T reg cells enhance antitumor immune responses. In this study, we show that depletion of CD25(+) T reg cells allows the host to induce both CD4(+) and CD8(+) antitumoral responses following tumor challenge. Simultaneous depletion of CD25(+) and CD8(+) cells, as well as adoptive transfer experiments, revealed that tumor-specific CD4(+) T cells, which emerged in the absence of CD25(+) T reg cells, were able to reject CT26 colon cancer cells, a MHC class II-negative tumor. The antitumoral effect mediated by CD4(+) T cells was dependent on IFN-gamma production, which exerted a potent antiangiogenic activity. The capacity of the host to mount this antitumor response is lost once the number of CD25(+) T reg cells is restored over time. However, CD25(+) T reg cell depletion before immunization with AH1 (a cytotoxic T cell determinant from CT26 tumor cells) permits the induction of a long-lasting antitumoral immune response, not observed if immunization is conducted in the presence of regulatory cells. A study of the effect of different levels of depletion of CD25(+) T reg cells before immunization with the peptide AH1 alone, or in combination with a Th determinant, unraveled that Th cells play an important role in overcoming the suppressive effect of CD25(+) T reg on the induction of long-lasting cellular immune responses.American Association of ImmunologistsDadun. Depósito Académico Digital Universidad de Navarra20122012-01-1520032003-01-0120032003-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20411reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/204112026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| title |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| spellingShingle |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination Casares-Lagar, N. (Noelia)|||/items/32524a9b-f393-47ee-bf77-0737c65e0b7b Angiogenesis Inhibitors/physiology CD4-Positive T-Lymphocytes/immunology Colonic Neoplasms/immunology Down-Regulation/immunology Interferon-gamma/physiology Lymphocyte Activation/immunology Peptides/immunology Receptors, Interleukin-2/biosynthesis T-Lymphocyte Subsets/immunology |
| title_short |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| title_full |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| title_fullStr |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| title_full_unstemmed |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| title_sort |
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination |
| dc.creator.none.fl_str_mv |
Casares-Lagar, N. (Noelia)|||/items/32524a9b-f393-47ee-bf77-0737c65e0b7b Arribillaga, L. (Laura)|||/items/a1a55d50-66c3-4216-9968-07b0c7f976cc Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Dotor, J. (Javier)|||/items/6606b7a3-73b7-49d9-bc1b-c565b3e1c208 Lopez-Diaz-de-Cerio, A. (Ascensión)|||/items/29ab6acb-fcbb-43ff-b4c1-e2dc95e22bcb Melero, I. (Ignacio)|||/items/82113ea8-7ce1-49d5-9ee3-42cf20db1c4e Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c |
| author |
Casares-Lagar, N. (Noelia)|||/items/32524a9b-f393-47ee-bf77-0737c65e0b7b |
| author_facet |
Casares-Lagar, N. (Noelia)|||/items/32524a9b-f393-47ee-bf77-0737c65e0b7b Arribillaga, L. (Laura)|||/items/a1a55d50-66c3-4216-9968-07b0c7f976cc Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Dotor, J. (Javier)|||/items/6606b7a3-73b7-49d9-bc1b-c565b3e1c208 Lopez-Diaz-de-Cerio, A. (Ascensión)|||/items/29ab6acb-fcbb-43ff-b4c1-e2dc95e22bcb Melero, I. (Ignacio)|||/items/82113ea8-7ce1-49d5-9ee3-42cf20db1c4e Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c |
| author_role |
author |
| author2 |
Arribillaga, L. (Laura)|||/items/a1a55d50-66c3-4216-9968-07b0c7f976cc Sarobe, P. (Pablo)|||/items/e6f6a7ac-cfe2-409e-ab14-057dea5fd160 Dotor, J. (Javier)|||/items/6606b7a3-73b7-49d9-bc1b-c565b3e1c208 Lopez-Diaz-de-Cerio, A. (Ascensión)|||/items/29ab6acb-fcbb-43ff-b4c1-e2dc95e22bcb Melero, I. (Ignacio)|||/items/82113ea8-7ce1-49d5-9ee3-42cf20db1c4e Lasarte-Sagastibelza, J.J. (Juan José)|||/items/e366ad83-3db4-41ec-a9da-ed9159ba5c0c |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Angiogenesis Inhibitors/physiology CD4-Positive T-Lymphocytes/immunology Colonic Neoplasms/immunology Down-Regulation/immunology Interferon-gamma/physiology Lymphocyte Activation/immunology Peptides/immunology Receptors, Interleukin-2/biosynthesis T-Lymphocyte Subsets/immunology |
| topic |
Angiogenesis Inhibitors/physiology CD4-Positive T-Lymphocytes/immunology Colonic Neoplasms/immunology Down-Regulation/immunology Interferon-gamma/physiology Lymphocyte Activation/immunology Peptides/immunology Receptors, Interleukin-2/biosynthesis T-Lymphocyte Subsets/immunology |
| description |
CD25(+) regulatory T (T reg) cells suppress the activation/proliferation of other CD4(+) or CD8(+) T cells in vitro. Also, down-regulation of CD25(+) T reg cells enhance antitumor immune responses. In this study, we show that depletion of CD25(+) T reg cells allows the host to induce both CD4(+) and CD8(+) antitumoral responses following tumor challenge. Simultaneous depletion of CD25(+) and CD8(+) cells, as well as adoptive transfer experiments, revealed that tumor-specific CD4(+) T cells, which emerged in the absence of CD25(+) T reg cells, were able to reject CT26 colon cancer cells, a MHC class II-negative tumor. The antitumoral effect mediated by CD4(+) T cells was dependent on IFN-gamma production, which exerted a potent antiangiogenic activity. The capacity of the host to mount this antitumor response is lost once the number of CD25(+) T reg cells is restored over time. However, CD25(+) T reg cell depletion before immunization with AH1 (a cytotoxic T cell determinant from CT26 tumor cells) permits the induction of a long-lasting antitumoral immune response, not observed if immunization is conducted in the presence of regulatory cells. A study of the effect of different levels of depletion of CD25(+) T reg cells before immunization with the peptide AH1 alone, or in combination with a Th determinant, unraveled that Th cells play an important role in overcoming the suppressive effect of CD25(+) T reg on the induction of long-lasting cellular immune responses. |
| publishDate |
2003 |
| dc.date.none.fl_str_mv |
2003 2003-01-01 2003 2003-01-01 2012 2012-01-15 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/20411 |
| url |
https://hdl.handle.net/10171/20411 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Association of Immunologists |
| publisher.none.fl_str_mv |
American Association of Immunologists |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869415393469136896 |
| score |
15,300724 |