Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms

With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promis...

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Autores: Tejo Otero, Aitor, Fenollosa Artés, Felip, Achaerandio, Isabel, Rey Vinolas, Sergi, Buj Corral, Irene, Mateos Timoneda, Miguel Ángel, Engel, Elisabeth
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185508
Acceso en línea:https://hdl.handle.net/2445/185508
Access Level:acceso abierto
Palabra clave:Enginyeria de teixits
Gels (Farmàcia)
Viscoelasticitat
Tissue engineering
Gels (Pharmacy)
Viscoelasticity
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spelling Soft-Tissue-Mimicking Using Hydrogels for the Development of PhantomsTejo Otero, AitorFenollosa Artés, FelipAchaerandio, IsabelRey Vinolas, SergiBuj Corral, IreneMateos Timoneda, Miguel ÁngelEngel, ElisabethEnginyeria de teixitsGels (Farmàcia)ViscoelasticitatTissue engineeringGels (Pharmacy)ViscoelasticityWith the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promising solution to simulate biological bodies. For this reason, to advance in the state-of-the-art a wide range of organs (e.g., liver, heart, kidney as well as brain) and hydrogels (e.g., agarose, polyvinyl alcohol –PVA–, Phytagel –PHY– and methacrylate gelatine –GelMA–) were tested regarding their mechanical properties. For that, viscoelastic behavior, hardness, as well as a non-linear elastic mechanical response were measured. It was seen that there was a significant difference among the results for the different mentioned soft tissues. Some of them appear to be more elastic than viscous as well as being softer or harder. With all this information in mind, a correlation between the mechanical properties of the organs and the different materials was performed. The next conclusions were drawn: (1) to mimic the liver, the best material is 1% wt agarose; (2) to mimic the heart, the best material is 2% wt agarose; (3) to mimic the kidney, the best material is 4% wt GelMA; and (4) to mimic the brain, the best materials are 4% wt GelMA and 1% wt agarose. Neither PVA nor PHY was selected to mimic any of the studied tissues.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185508Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/gels8010040Gels, 2022, vol.8, num. 1, p. 40https://doi.org/10.3390/gels8010040cc by (c) Tejo Otero, Aitor et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1855082026-05-27T06:46:51Z
dc.title.none.fl_str_mv Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
title Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
spellingShingle Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
Tejo Otero, Aitor
Enginyeria de teixits
Gels (Farmàcia)
Viscoelasticitat
Tissue engineering
Gels (Pharmacy)
Viscoelasticity
title_short Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
title_full Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
title_fullStr Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
title_full_unstemmed Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
title_sort Soft-Tissue-Mimicking Using Hydrogels for the Development of Phantoms
dc.creator.none.fl_str_mv Tejo Otero, Aitor
Fenollosa Artés, Felip
Achaerandio, Isabel
Rey Vinolas, Sergi
Buj Corral, Irene
Mateos Timoneda, Miguel Ángel
Engel, Elisabeth
author Tejo Otero, Aitor
author_facet Tejo Otero, Aitor
Fenollosa Artés, Felip
Achaerandio, Isabel
Rey Vinolas, Sergi
Buj Corral, Irene
Mateos Timoneda, Miguel Ángel
Engel, Elisabeth
author_role author
author2 Fenollosa Artés, Felip
Achaerandio, Isabel
Rey Vinolas, Sergi
Buj Corral, Irene
Mateos Timoneda, Miguel Ángel
Engel, Elisabeth
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Enginyeria de teixits
Gels (Farmàcia)
Viscoelasticitat
Tissue engineering
Gels (Pharmacy)
Viscoelasticity
topic Enginyeria de teixits
Gels (Farmàcia)
Viscoelasticitat
Tissue engineering
Gels (Pharmacy)
Viscoelasticity
description With the currently available materials and technologies it is difficult to mimic the mechanical properties of soft living tissues. Additionally, another significant problem is the lack of information about the mechanical properties of these tissues. Alternatively, the use of phantoms offers a promising solution to simulate biological bodies. For this reason, to advance in the state-of-the-art a wide range of organs (e.g., liver, heart, kidney as well as brain) and hydrogels (e.g., agarose, polyvinyl alcohol –PVA–, Phytagel –PHY– and methacrylate gelatine –GelMA–) were tested regarding their mechanical properties. For that, viscoelastic behavior, hardness, as well as a non-linear elastic mechanical response were measured. It was seen that there was a significant difference among the results for the different mentioned soft tissues. Some of them appear to be more elastic than viscous as well as being softer or harder. With all this information in mind, a correlation between the mechanical properties of the organs and the different materials was performed. The next conclusions were drawn: (1) to mimic the liver, the best material is 1% wt agarose; (2) to mimic the heart, the best material is 2% wt agarose; (3) to mimic the kidney, the best material is 4% wt GelMA; and (4) to mimic the brain, the best materials are 4% wt GelMA and 1% wt agarose. Neither PVA nor PHY was selected to mimic any of the studied tissues.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185508
url https://hdl.handle.net/2445/185508
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/gels8010040
Gels, 2022, vol.8, num. 1, p. 40
https://doi.org/10.3390/gels8010040
dc.rights.none.fl_str_mv cc by (c) Tejo Otero, Aitor et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Tejo Otero, Aitor et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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