Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity

© 2021 Herrera et al.

Detalles Bibliográficos
Autores: Herrera, Antonio, Menendez, Anghara, Torroba, Blanca, Ochoa, Andrea, Pons, Sebastián
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/241513
Acceso en línea:http://hdl.handle.net/10261/241513
Access Level:acceso abierto
Palabra clave:Adhesion
Development
Polarity
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repository_id_str
spelling Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarityHerrera, AntonioMenendez, AngharaTorroba, BlancaOchoa, AndreaPons, SebastiánAdhesionDevelopmentPolarity© 2021 Herrera et al.The neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) concentrate in the subapical domain. We previously reported that sustained β-catenin expression promotes the formation of enlarged apical complexes (ACs), enhancing apico-basal polarity, although the mechanism through which this occurs remained unclear. Here, we show that β-catenin interacts with phosphorylated pro-N-cadherin early in its transit through the Golgi apparatus, promoting propeptide excision and the final maturation of N-cadherin. We describe a new β-catenin–dependent interaction of N-cadherin with Drebrin-like (Dbnl), an actin-binding protein that is involved in anterograde Golgi trafficking of proteins. Notably, Dbnl knockdown led to pro-N-cadherin accumulation and limited AJ formation. In brief, we demonstrate that Dbnl and β-catenin assist in the maturation of pro-N-cadherin, which is critical for AJ formation and for the recruitment AC components like aPKC and, consequently, for the maintenance of apico-basal polarity.Ministerio de Economía y Competitividad (BFU2014-53633-P)Rockefeller University PressMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/241513reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-53633-Phttp://dx.doi.org/10.1083/jcb.202007055Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2415132026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
title Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
spellingShingle Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
Herrera, Antonio
Adhesion
Development
Polarity
title_short Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
title_full Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
title_fullStr Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
title_full_unstemmed Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
title_sort Dbnl and ß-catenin promote pro-N-cadherin processing to maintain apico-basal polarity
dc.creator.none.fl_str_mv Herrera, Antonio
Menendez, Anghara
Torroba, Blanca
Ochoa, Andrea
Pons, Sebastián
author Herrera, Antonio
author_facet Herrera, Antonio
Menendez, Anghara
Torroba, Blanca
Ochoa, Andrea
Pons, Sebastián
author_role author
author2 Menendez, Anghara
Torroba, Blanca
Ochoa, Andrea
Pons, Sebastián
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Adhesion
Development
Polarity
topic Adhesion
Development
Polarity
description © 2021 Herrera et al.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/241513
url http://hdl.handle.net/10261/241513
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-53633-P
http://dx.doi.org/10.1083/jcb.202007055
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Rockefeller University Press
publisher.none.fl_str_mv Rockefeller University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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