Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex

A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. The use of new techniques based on tandem affinity purification (TAP) and chromatin immunoprecipitation (ChIP), and of genetic and cell biology approaches has contributed to t...

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Authors: Luna Varo, Rosa María, González Aguilera, Cristina, Aguilera López, Andrés
Format: article
Status:Versión aceptada para publicación
Publication Date:2009
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/72223
Online Access:https://hdl.handle.net/11441/72223
https://doi.org/10.4161/rna.6.2.7803
Access Level:Open access
Keyword:Gene expression
Transcription elongation
mRNA export
Thp1-Sac3-Sus1-Cdc31
Gene tethering
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spelling Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complexLuna Varo, Rosa MaríaGonzález Aguilera, CristinaAguilera López, AndrésGene expressionTranscription elongationmRNA exportThp1-Sac3-Sus1-Cdc31Gene tetheringA key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. The use of new techniques based on tandem affinity purification (TAP) and chromatin immunoprecipitation (ChIP), and of genetic and cell biology approaches has contributed to the beginning of deciphering the network of protein-mRNA interactions accompanying this coupling. Although an extensive amount of work has shed light on this matter, the order of participation and precise role of the different proteins remain to be deciphered. It seems that different and sequential protein interactions must converge to finally promote the anchoring of genes to the nuclear periphery. Here we discuss the new data on the coupling of gene expression and RNA export, with emphasis on the THP1-SAC3-SUS1-CDC31 complex and the possible implications of these results on transcription at the nuclear pore.Landes BioscienceGenética2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/72223https://doi.org/10.4161/rna.6.2.7803reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésRNA Biology, 6 (2), 145-148.http://dx.doi.org/10.4161/rna.6.2.7803info:eu-repo/semantics/openAccessoai:idus.us.es:11441/722232026-06-17T12:51:07Z
dc.title.none.fl_str_mv Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
title Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
spellingShingle Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
Luna Varo, Rosa María
Gene expression
Transcription elongation
mRNA export
Thp1-Sac3-Sus1-Cdc31
Gene tethering
title_short Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
title_full Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
title_fullStr Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
title_full_unstemmed Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
title_sort Transcription at the proximity of the nuclear pore: A role for the THP1-SAC3-SUS1-CDC31 (THSC) complex
dc.creator.none.fl_str_mv Luna Varo, Rosa María
González Aguilera, Cristina
Aguilera López, Andrés
author Luna Varo, Rosa María
author_facet Luna Varo, Rosa María
González Aguilera, Cristina
Aguilera López, Andrés
author_role author
author2 González Aguilera, Cristina
Aguilera López, Andrés
author2_role author
author
dc.contributor.none.fl_str_mv Genética
dc.subject.none.fl_str_mv Gene expression
Transcription elongation
mRNA export
Thp1-Sac3-Sus1-Cdc31
Gene tethering
topic Gene expression
Transcription elongation
mRNA export
Thp1-Sac3-Sus1-Cdc31
Gene tethering
description A key aspect of eukaryotic gene expression is the coupling of transcription with RNA processing, polyadenylation and export. The use of new techniques based on tandem affinity purification (TAP) and chromatin immunoprecipitation (ChIP), and of genetic and cell biology approaches has contributed to the beginning of deciphering the network of protein-mRNA interactions accompanying this coupling. Although an extensive amount of work has shed light on this matter, the order of participation and precise role of the different proteins remain to be deciphered. It seems that different and sequential protein interactions must converge to finally promote the anchoring of genes to the nuclear periphery. Here we discuss the new data on the coupling of gene expression and RNA export, with emphasis on the THP1-SAC3-SUS1-CDC31 complex and the possible implications of these results on transcription at the nuclear pore.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/72223
https://doi.org/10.4161/rna.6.2.7803
url https://hdl.handle.net/11441/72223
https://doi.org/10.4161/rna.6.2.7803
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv RNA Biology, 6 (2), 145-148.
http://dx.doi.org/10.4161/rna.6.2.7803
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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