Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa

Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestin...

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Autores: Bernardo Ordiz, David, Garrote Adrados, José Antonio, Nadal, I., León, Alberto José, Calvo Romero, María Del Carmen, Fernández Salazar, Luis Ignacio, Blanco Quiros, Alfredo, Sanz, Y., Arranz Sanz, Eduardo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2009
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/4436
Acceso en línea:https://doi.org/10.1136/gut.2008.167296
http://uvadoc.uva.es/handle/10324/4436
Access Level:acceso abierto
Palabra clave:Enfermedad celíaca
Gliadina
Intestinos - Enfermedades
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spelling Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosaBernardo Ordiz, DavidGarrote Adrados, José AntonioNadal, I.León, Alberto JoséCalvo Romero, María Del CarmenFernández Salazar, Luis IgnacioBlanco Quiros, AlfredoSanz, Y.Arranz Sanz, EduardoEnfermedad celíacaGliadinaIntestinos - EnfermedadesProlyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD.BMJ2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1136/gut.2008.167296http://uvadoc.uva.es/handle/10324/4436reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://gut.bmj.com/content/58/6/886info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/44362026-06-13T12:44:47Z
dc.title.none.fl_str_mv Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
title Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
spellingShingle Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
Bernardo Ordiz, David
Enfermedad celíaca
Gliadina
Intestinos - Enfermedades
title_short Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
title_full Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
title_fullStr Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
title_full_unstemmed Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
title_sort Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
dc.creator.none.fl_str_mv Bernardo Ordiz, David
Garrote Adrados, José Antonio
Nadal, I.
León, Alberto José
Calvo Romero, María Del Carmen
Fernández Salazar, Luis Ignacio
Blanco Quiros, Alfredo
Sanz, Y.
Arranz Sanz, Eduardo
author Bernardo Ordiz, David
author_facet Bernardo Ordiz, David
Garrote Adrados, José Antonio
Nadal, I.
León, Alberto José
Calvo Romero, María Del Carmen
Fernández Salazar, Luis Ignacio
Blanco Quiros, Alfredo
Sanz, Y.
Arranz Sanz, Eduardo
author_role author
author2 Garrote Adrados, José Antonio
Nadal, I.
León, Alberto José
Calvo Romero, María Del Carmen
Fernández Salazar, Luis Ignacio
Blanco Quiros, Alfredo
Sanz, Y.
Arranz Sanz, Eduardo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedad celíaca
Gliadina
Intestinos - Enfermedades
topic Enfermedad celíaca
Gliadina
Intestinos - Enfermedades
description Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1136/gut.2008.167296
http://uvadoc.uva.es/handle/10324/4436
url https://doi.org/10.1136/gut.2008.167296
http://uvadoc.uva.es/handle/10324/4436
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://gut.bmj.com/content/58/6/886
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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