Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression

Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic...

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Autores: Canyelles, Marina, Tondo, Mireia, Lindholt, Jes S., Santos, David, Fernández-Alonso, Irati, Gonzalo-Calvo, David de, Blanco-Colio, Luis Miguel, Escolà-Gil, Joan Carles, Martín-Ventura, Jose Luis, Blanco-Vaca, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/223779
Acceso en línea:http://hdl.handle.net/10261/223779
Access Level:acceso abierto
Palabra clave:Abdominal aortic aneurysm
Cardiovascular disease
Cholesterol efflux
HDL
ApoA-I
Aortic diameter
Growth rate
Need for surgery
Reverse cholesterol transport
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spelling Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) ProgressionCanyelles, MarinaTondo, MireiaLindholt, Jes S.Santos, DavidFernández-Alonso, IratiGonzalo-Calvo, David deBlanco-Colio, Luis MiguelEscolà-Gil, Joan CarlesMartín-Ventura, Jose LuisBlanco-Vaca, FranciscoAbdominal aortic aneurysmCardiovascular diseaseCholesterol effluxHDLApoA-IAortic diameterGrowth rateNeed for surgeryReverse cholesterol transportRecent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic diameter between 30 and 50 mm) and 38 control subjects (aortic diameter < 30 mm). We evaluated the potential of HDL-mediated macrophage cholesterol efflux (MCE) to predict AAA growth and/or the need for surgery. MCE was impaired in the large aortic diameter AAA group as compared with that in the small/medium size AAA group and the control group. However, no significant difference in HDL-mediated MCE capacity was observed in 3 different progression subgroups (classified according to growth rate < 1 mm per year, between 1 and 5 mm per year or >5 mm per year) in patients with small/medium size AAA. Moreover, no correlation was found between MCE capacity and the aneurysm growth rate. A multivariate Cox regression analysis revealed a significant association between lower MCE capacity with the need for surgery in all AAA patients. Nevertheless, the significance was lost when only small/medium size AAA patients were included. Our results suggest that MCE, a major HDL functional activity, is not involved in AAA progression.This work was partly funded by the Instituto de Salud Carlos III and FEDER “Una manera de hacer Europa” grants FIS 16-00139 (to J.C.E-G), FIS 18-00164 (to F.B.-V. and M.T.), Spanish MINECO (SAF2016-80843-R) and La Caixa Foundation (HR17-00247). CIBERDEM and CIBERCV are Instituto de Salud Carlos III projects.Peer reviewedMolecular Diversity Preservation InternationalInstituto de Salud Carlos IIIEuropean CommissionMinisterio de Economía y Competitividad (España)Fundación la CaixaCentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España)Tondo, Mireia [0000-0002-0301-9984]Gonzalo-Calvo, David de [0000-0003-2240-3532]Blanco-Colio, Luis Miguel [0000-0002-1560-6609]Escolà-Gil, Joan Carles [0000-0001-9021-2485]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/223779reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-80843-Rhttps://doi.org/10.3390/biom10040662Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2237792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
title Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
spellingShingle Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
Canyelles, Marina
Abdominal aortic aneurysm
Cardiovascular disease
Cholesterol efflux
HDL
ApoA-I
Aortic diameter
Growth rate
Need for surgery
Reverse cholesterol transport
title_short Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
title_full Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
title_fullStr Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
title_full_unstemmed Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
title_sort Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
dc.creator.none.fl_str_mv Canyelles, Marina
Tondo, Mireia
Lindholt, Jes S.
Santos, David
Fernández-Alonso, Irati
Gonzalo-Calvo, David de
Blanco-Colio, Luis Miguel
Escolà-Gil, Joan Carles
Martín-Ventura, Jose Luis
Blanco-Vaca, Francisco
author Canyelles, Marina
author_facet Canyelles, Marina
Tondo, Mireia
Lindholt, Jes S.
Santos, David
Fernández-Alonso, Irati
Gonzalo-Calvo, David de
Blanco-Colio, Luis Miguel
Escolà-Gil, Joan Carles
Martín-Ventura, Jose Luis
Blanco-Vaca, Francisco
author_role author
author2 Tondo, Mireia
Lindholt, Jes S.
Santos, David
Fernández-Alonso, Irati
Gonzalo-Calvo, David de
Blanco-Colio, Luis Miguel
Escolà-Gil, Joan Carles
Martín-Ventura, Jose Luis
Blanco-Vaca, Francisco
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Ministerio de Economía y Competitividad (España)
Fundación la Caixa
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (España)
Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España)
Tondo, Mireia [0000-0002-0301-9984]
Gonzalo-Calvo, David de [0000-0003-2240-3532]
Blanco-Colio, Luis Miguel [0000-0002-1560-6609]
Escolà-Gil, Joan Carles [0000-0001-9021-2485]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Abdominal aortic aneurysm
Cardiovascular disease
Cholesterol efflux
HDL
ApoA-I
Aortic diameter
Growth rate
Need for surgery
Reverse cholesterol transport
topic Abdominal aortic aneurysm
Cardiovascular disease
Cholesterol efflux
HDL
ApoA-I
Aortic diameter
Growth rate
Need for surgery
Reverse cholesterol transport
description Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic diameter between 30 and 50 mm) and 38 control subjects (aortic diameter < 30 mm). We evaluated the potential of HDL-mediated macrophage cholesterol efflux (MCE) to predict AAA growth and/or the need for surgery. MCE was impaired in the large aortic diameter AAA group as compared with that in the small/medium size AAA group and the control group. However, no significant difference in HDL-mediated MCE capacity was observed in 3 different progression subgroups (classified according to growth rate < 1 mm per year, between 1 and 5 mm per year or >5 mm per year) in patients with small/medium size AAA. Moreover, no correlation was found between MCE capacity and the aneurysm growth rate. A multivariate Cox regression analysis revealed a significant association between lower MCE capacity with the need for surgery in all AAA patients. Nevertheless, the significance was lost when only small/medium size AAA patients were included. Our results suggest that MCE, a major HDL functional activity, is not involved in AAA progression.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/223779
url http://hdl.handle.net/10261/223779
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-80843-R
https://doi.org/10.3390/biom10040662
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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