Carbon dioxide sorption and melting behaviour of mPEG-alkyne
The understanding of the phase behaviour of the mixture mPEG-alkyne and supercritical CO2 (scCO2) and the study of the variation of the polymer melting point are essential prerequisites in order to determine appropriate operating conditions and develop high pressure processes that allow the obtentio...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/29939 |
| Acceso en línea: | http://hdl.handle.net/10578/29939 |
| Access Level: | acceso abierto |
| Palabra clave: | Supercritical CO2 MPEG-alkyne Melting point Sorption CO2 supercrítico MPEG-alquino Punto de fusión Sorción |
| Sumario: | The understanding of the phase behaviour of the mixture mPEG-alkyne and supercritical CO2 (scCO2) and the study of the variation of the polymer melting point are essential prerequisites in order to determine appropriate operating conditions and develop high pressure processes that allow the obtention of a conjugate mPEG-alkyne with a drug or a protein. In this work, it was observed a progressive decrease of the melting point temperature of mPEG-alkyne induced by the adsorption of CO2. The obtained melting temperatures were correlated using a modification of the Clausius Clapeyron equation. The equilibrium sorption of CO2 into mPEG-alkyne was determined with a variable-volume view cell employing a static method. These experiments were carried out in the temperature range 308 and 318 K, and at 8–17 MPa of pressure. The prediction capabilities of the models of Henry’s Law, Dual-Mode, Sanchez Lacombe Equation of State and Heuristic Model was evaluated. |
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