The evolutionary consequences of transposon-related pericentromer expansion in melon

Transposable elements (TEs) are a major driver of plant genome evolution. A part from being a rich source of new genes and regulatory sequences, TEs can also affect plant genome evolution by modifying genome size and shaping chromosome structure. TEs tend to concentrate in heterochromatic pericentro...

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Autores: Morata, Jordi, Tormo, Marc, Alexiou, Konstantinos G., Vives, Cristina, Ramos-Onsins, Sebastian E., García-Mas, Jordi, Casacuberta, Josep M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/250329
Acceso en línea:http://hdl.handle.net/10261/250329
Access Level:acceso abierto
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spelling The evolutionary consequences of transposon-related pericentromer expansion in melonMorata, JordiTormo, MarcAlexiou, Konstantinos G.Vives, CristinaRamos-Onsins, Sebastian E.García-Mas, JordiCasacuberta, Josep M.Transposable elements (TEs) are a major driver of plant genome evolution. A part from being a rich source of new genes and regulatory sequences, TEs can also affect plant genome evolution by modifying genome size and shaping chromosome structure. TEs tend to concentrate in heterochromatic pericentromeric regions and their proliferation may expand these regions. Here, we show that after the split of melon and cucumber, TEs have expanded the pericentromeric regions of melon chromosomes that, probably as a consequence, show a very low recombination frequency. In contrast, TEs have not proliferated to a high extent in cucumber, which has small TE-dense pericentromeric regions and shows a relatively constant recombination rate along chromosomes. These differences in chromosome structure also translate in differences in gene nucleotide diversity. Although gene nucleotide diversity is essentially constant along cucumber chromosomes, melon chromosomes show a bimodal pattern of genetic variability, with a gene-poor region where variability is negatively correlated with gene density. Interestingly, genes are not homogeneously distributed in melon, and the high variable low-recombining pericentromeric regions show a higher concentration of melon-specific genes whereas genes shared with cucumber and other plants are essentially found in gene-rich chromosomal arms. The results presented here suggest that melon pericentromeric regions may allow gene sequences to evolve more freely than in other chromosomal compartments which may allow new ORFs to arise and eventually be selected. These results show that TEs can drastically change the structure of chromosomes creating different chromosomal compartments imposing different constraints for gene evolution.This work was supported by Ministerio de Economia y Competitividad grants AGL2013-43244-R and AGL2016-78992-R to J.C., Ministerio de Economia y Competitividad grant AGL2015-64625-C2-1-R to J.G.-M. and Centro de Excelencia Severo Ochoa 2016–2020, and the CERCA Programme/Generalitat de Catalunya to J.C., J.G.-M. and S.R.-O.Peer reviewedOxford University PressMinisterio de Economía y Competitividad (España)Generalitat de CatalunyaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/250329reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-43244-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78992-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64625-C2-1-Rhttps://doi.org/10.1093/gbe/evy115Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2503292026-05-22T06:33:51Z
dc.title.none.fl_str_mv The evolutionary consequences of transposon-related pericentromer expansion in melon
title The evolutionary consequences of transposon-related pericentromer expansion in melon
spellingShingle The evolutionary consequences of transposon-related pericentromer expansion in melon
Morata, Jordi
title_short The evolutionary consequences of transposon-related pericentromer expansion in melon
title_full The evolutionary consequences of transposon-related pericentromer expansion in melon
title_fullStr The evolutionary consequences of transposon-related pericentromer expansion in melon
title_full_unstemmed The evolutionary consequences of transposon-related pericentromer expansion in melon
title_sort The evolutionary consequences of transposon-related pericentromer expansion in melon
dc.creator.none.fl_str_mv Morata, Jordi
Tormo, Marc
Alexiou, Konstantinos G.
Vives, Cristina
Ramos-Onsins, Sebastian E.
García-Mas, Jordi
Casacuberta, Josep M.
author Morata, Jordi
author_facet Morata, Jordi
Tormo, Marc
Alexiou, Konstantinos G.
Vives, Cristina
Ramos-Onsins, Sebastian E.
García-Mas, Jordi
Casacuberta, Josep M.
author_role author
author2 Tormo, Marc
Alexiou, Konstantinos G.
Vives, Cristina
Ramos-Onsins, Sebastian E.
García-Mas, Jordi
Casacuberta, Josep M.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Generalitat de Catalunya
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Transposable elements (TEs) are a major driver of plant genome evolution. A part from being a rich source of new genes and regulatory sequences, TEs can also affect plant genome evolution by modifying genome size and shaping chromosome structure. TEs tend to concentrate in heterochromatic pericentromeric regions and their proliferation may expand these regions. Here, we show that after the split of melon and cucumber, TEs have expanded the pericentromeric regions of melon chromosomes that, probably as a consequence, show a very low recombination frequency. In contrast, TEs have not proliferated to a high extent in cucumber, which has small TE-dense pericentromeric regions and shows a relatively constant recombination rate along chromosomes. These differences in chromosome structure also translate in differences in gene nucleotide diversity. Although gene nucleotide diversity is essentially constant along cucumber chromosomes, melon chromosomes show a bimodal pattern of genetic variability, with a gene-poor region where variability is negatively correlated with gene density. Interestingly, genes are not homogeneously distributed in melon, and the high variable low-recombining pericentromeric regions show a higher concentration of melon-specific genes whereas genes shared with cucumber and other plants are essentially found in gene-rich chromosomal arms. The results presented here suggest that melon pericentromeric regions may allow gene sequences to evolve more freely than in other chromosomal compartments which may allow new ORFs to arise and eventually be selected. These results show that TEs can drastically change the structure of chromosomes creating different chromosomal compartments imposing different constraints for gene evolution.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/250329
url http://hdl.handle.net/10261/250329
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-43244-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78992-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-64625-C2-1-R
https://doi.org/10.1093/gbe/evy115
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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