The Y chromosome: male reproduction and beyond

The crucial role of Y chromosome genes in male gonadal determination and reproductive fitness has been recognized for decades. Y chromosome microdeletions are the most common molecular genetic causes of azoospermia and severe spermatogenic impairment. Since the late 1990s, screening for these microd...

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Detalles Bibliográficos
Autores: Krausz, C, Abrardo, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19672
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19672
Access Level:acceso abierto
Palabra clave:Y chromosome
male infertility
genetics
AZF deletion
azoospermia
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spelling The Y chromosome: male reproduction and beyondKrausz, CAbrardo, CY chromosomemale infertilitygeneticsAZF deletionazoospermiaThe crucial role of Y chromosome genes in male gonadal determination and reproductive fitness has been recognized for decades. Y chromosome microdeletions are the most common molecular genetic causes of azoospermia and severe spermatogenic impairment. Since the late 1990s, screening for these microdeletions has become a routine part of the diagnostic work-up of severe male factor infertility. In this article, we provide a concise overview of the Y chromosome's structure and gene content. We describe its clinically relevant alterations, detectable through karyotyping or molecular genetic tools, with a focus on their phenotypic impact and significance for genetic counseling. Finally, we discuss the broader implications of Y chromosome variations on health conditions beyond male infertility. (Fertil Steril (R) 2025;123:921-32. (c) 2025 by American Society for Reproductive Medicine.)ELSEVIER SCIENCE INC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19672FERTILITY AND STERILITYISSN: 00150282ISSNe: 15565653reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p196722026-06-14T12:41:47Z
dc.title.none.fl_str_mv The Y chromosome: male reproduction and beyond
title The Y chromosome: male reproduction and beyond
spellingShingle The Y chromosome: male reproduction and beyond
Krausz, C
Y chromosome
male infertility
genetics
AZF deletion
azoospermia
title_short The Y chromosome: male reproduction and beyond
title_full The Y chromosome: male reproduction and beyond
title_fullStr The Y chromosome: male reproduction and beyond
title_full_unstemmed The Y chromosome: male reproduction and beyond
title_sort The Y chromosome: male reproduction and beyond
dc.creator.none.fl_str_mv Krausz, C
Abrardo, C
author Krausz, C
author_facet Krausz, C
Abrardo, C
author_role author
author2 Abrardo, C
author2_role author
dc.subject.none.fl_str_mv Y chromosome
male infertility
genetics
AZF deletion
azoospermia
topic Y chromosome
male infertility
genetics
AZF deletion
azoospermia
description The crucial role of Y chromosome genes in male gonadal determination and reproductive fitness has been recognized for decades. Y chromosome microdeletions are the most common molecular genetic causes of azoospermia and severe spermatogenic impairment. Since the late 1990s, screening for these microdeletions has become a routine part of the diagnostic work-up of severe male factor infertility. In this article, we provide a concise overview of the Y chromosome's structure and gene content. We describe its clinically relevant alterations, detectable through karyotyping or molecular genetic tools, with a focus on their phenotypic impact and significance for genetic counseling. Finally, we discuss the broader implications of Y chromosome variations on health conditions beyond male infertility. (Fertil Steril (R) 2025;123:921-32. (c) 2025 by American Society for Reproductive Medicine.)
publishDate 2025
dc.date.none.fl_str_mv 2025
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19672
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19672
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv FERTILITY AND STERILITY
ISSN: 00150282
ISSNe: 15565653
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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