Notch signaling directly controls cell proliferation in the Drosophila wing disc

Notch signaling is involved in cell differentiation and patterning during morphogenesis. In the Drosophila wing, Notch activity regulates the expression of several genes at the dorsal/ventral boundary, and this is thought to elicit wing-cell proliferation. In this work, we show the effect of clones...

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Detalles Bibliográficos
Autores: Baonza, Antonio, García-Bellido, Antonio
Tipo de recurso: artículo
Fecha de publicación:2000
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48349
Acceso en línea:http://hdl.handle.net/10261/48349
Access Level:acceso embargado
Palabra clave:Drosophila
Wings
Notch
Disc
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oai_identifier_str oai:digital.csic.es:10261/48349
network_acronym_str ES
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repository_id_str
spelling Notch signaling directly controls cell proliferation in the Drosophila wing discBaonza, AntonioGarcía-Bellido, AntonioDrosophilaWingsNotchDiscNotch signaling is involved in cell differentiation and patterning during morphogenesis. In the Drosophila wing, Notch activity regulates the expression of several genes at the dorsal/ventral boundary, and this is thought to elicit wing-cell proliferation. In this work, we show the effect of clones of cells expressing different forms of several members of the Notch signaling pathway, which result in an alteration of Notch activity. The ectopic expression in clones of activated forms of Notch or of its ligands (Delta or Serrate) in the wing causes outgrowths associated with the appearance of ectopic wing margins. These outgrowths consist of mutant territories and of surrounding wild-type cells. However, the ectopic expression of Delta, at low levels in ventral clones, causes large outgrowths that are associated neither with the generation of wing margin structures nor with the expression of genes characteristic of the dorsal/ventral boundary. These results suggest that Notch activity is directly involved in cell proliferation, independently of its role in the formation of the dorsal/ventral boundary. We propose that the nonautonomous effects (induction of extraproliferation and vein differentiation in the surrounding wild-type cells) result from pattern accommodation to positional values caused by the ectopic expression of Notch.Peer reviewedNational Academy of Sciences (U.S.)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220122000info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48349reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.040576497Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/483492026-05-22T06:33:51Z
dc.title.none.fl_str_mv Notch signaling directly controls cell proliferation in the Drosophila wing disc
title Notch signaling directly controls cell proliferation in the Drosophila wing disc
spellingShingle Notch signaling directly controls cell proliferation in the Drosophila wing disc
Baonza, Antonio
Drosophila
Wings
Notch
Disc
title_short Notch signaling directly controls cell proliferation in the Drosophila wing disc
title_full Notch signaling directly controls cell proliferation in the Drosophila wing disc
title_fullStr Notch signaling directly controls cell proliferation in the Drosophila wing disc
title_full_unstemmed Notch signaling directly controls cell proliferation in the Drosophila wing disc
title_sort Notch signaling directly controls cell proliferation in the Drosophila wing disc
dc.creator.none.fl_str_mv Baonza, Antonio
García-Bellido, Antonio
author Baonza, Antonio
author_facet Baonza, Antonio
García-Bellido, Antonio
author_role author
author2 García-Bellido, Antonio
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Wings
Notch
Disc
topic Drosophila
Wings
Notch
Disc
description Notch signaling is involved in cell differentiation and patterning during morphogenesis. In the Drosophila wing, Notch activity regulates the expression of several genes at the dorsal/ventral boundary, and this is thought to elicit wing-cell proliferation. In this work, we show the effect of clones of cells expressing different forms of several members of the Notch signaling pathway, which result in an alteration of Notch activity. The ectopic expression in clones of activated forms of Notch or of its ligands (Delta or Serrate) in the wing causes outgrowths associated with the appearance of ectopic wing margins. These outgrowths consist of mutant territories and of surrounding wild-type cells. However, the ectopic expression of Delta, at low levels in ventral clones, causes large outgrowths that are associated neither with the generation of wing margin structures nor with the expression of genes characteristic of the dorsal/ventral boundary. These results suggest that Notch activity is directly involved in cell proliferation, independently of its role in the formation of the dorsal/ventral boundary. We propose that the nonautonomous effects (induction of extraproliferation and vein differentiation in the surrounding wild-type cells) result from pattern accommodation to positional values caused by the ectopic expression of Notch.
publishDate 2000
dc.date.none.fl_str_mv 2000
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48349
url http://hdl.handle.net/10261/48349
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.040576497
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,30478

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